Research graph
References from Two functionally distinct amyloid-β intermediates link aggregation pathways to pathology in Alzheimer’s disease. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1126/science.1566067
10.1126/science.1566067 · External reference
10.1038/nrm3810
10.1038/nrm3810 · External reference
10.1126/science.1072994
10.1126/science.1072994 · External reference
10.1038/s41582-024-00942-2
10.1038/s41582-024-00942-2 · External reference
Amyloid Accumulation and Cognitive Decline in Clinically Normal Older Individuals: Implications for Aging and Early Alzheimer’s Disease
10.3233/jad-179928 · 2018 · External reference
10.1212/wnl.42.3.631
10.1212/wnl.42.3.631 · External reference
10.1016/j.cell.2023.08.021
10.1016/j.cell.2023.08.021 · External reference
10.1016/j.cell.2023.09.023
10.1016/j.cell.2023.09.023 · External reference
10.1007/s00401-018-1918-8
10.1007/s00401-018-1918-8 · External reference
10.1371/journal.pbio.3001694
10.1371/journal.pbio.3001694 · External reference
10.1038/nm1782
10.1038/nm1782 · External reference
10.1038/nn.3028
10.1038/nn.3028 · External reference
10.1126/science.1079469
10.1126/science.1079469 · External reference
10.1002/alz.14415
10.1002/alz.14415 · External reference
10.1016/j.nbd.2009.05.024
10.1016/j.nbd.2009.05.024 · External reference
10.1016/s0002-9440(10)65184-x
10.1016/s0002-9440(10)65184-x · External reference
10.1021/bi00069a001
10.1021/bi00069a001 · External reference
10.1016/s0002-9440(10)64700-1
10.1016/s0002-9440(10)64700-1 · External reference
10.1016/0896-6273(94)90458-8
10.1016/0896-6273(94)90458-8 · External reference
10.1038/s41467-019-09477-3
10.1038/s41467-019-09477-3 · External reference
10.1007/s00401-016-1662-x
10.1007/s00401-016-1662-x · External reference
10.1016/j.neures.2025.104959
10.1016/j.neures.2025.104959 · External reference
Imaging individual protein aggregates to follow aggregation and determine the role of aggregates in neurodegenerative disease. Biochim. Biophys
10.1016/j.bbapap.2018.12.010 · 2019 · External reference
10.1186/s40478-019-0822-3
10.1186/s40478-019-0822-3 · External reference
10.1016/j.neuron.2023.04.007
10.1016/j.neuron.2023.04.007 · External reference
Amyloid-β oligomers, curvilinear and annular assemblies, imaged by cryo-ET, cryo-EM, and AFM
10.1126/sciadv.adx9030 · 2025 · External reference
10.1038/s41467-020-16566-1
10.1038/s41467-020-16566-1 · External reference
10.1038/nsmb.2991
10.1038/nsmb.2991 · External reference
Soluble amyloid beta-containing aggregates are present throughout the brain at early stages of Alzheimer’s disease
10.1093/braincomms/fcab147 · 2021 · External reference
Targeting protein disorder: the next hurdle in drug discovery
10.1038/s41573-025-01220-6 · 2025 · External reference
10.1111/j.1749-6632.1994.tb44398.x
10.1111/j.1749-6632.1994.tb44398.x · External reference
10.1111/j.1749-6632.1994.tb44424.x
10.1111/j.1749-6632.1994.tb44424.x · External reference
10.1186/s13024-017-0169-9
10.1186/s13024-017-0169-9 · External reference
10.1126/science.aay0198
10.1126/science.aay0198 · External reference
10.1016/s0092-8674(01)00264-1
10.1016/s0092-8674(01)00264-1 · External reference
10.1111/j.1471-4159.2011.07447.x
10.1111/j.1471-4159.2011.07447.x · External reference
10.1021/ja805030w
10.1021/ja805030w · External reference
10.1083/jcb.201104133
10.1083/jcb.201104133 · External reference
10.1073/pnas.0502066102
10.1073/pnas.0502066102 · External reference
Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro
10.1038/s42003-020-0757-z · 2020 · External reference
10.1038/s41467-017-02056-4
10.1038/s41467-017-02056-4 · External reference
Learnings about Aβ from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer’s disease immunotherapeutics
10.1186/s40478-023-01511-2 · 2023 · External reference
10.1073/pnas.1218402110
10.1073/pnas.1218402110 · External reference
10.1038/s41557-020-0452-1
10.1038/s41557-020-0452-1 · External reference
10.1039/c9sc06501f
10.1039/c9sc06501f · External reference
10.1073/pnas.1922267117
10.1073/pnas.1922267117 · External reference
10.1038/nsmb.2971
10.1038/nsmb.2971 · External reference
10.1007/s00401-018-1846-7
10.1007/s00401-018-1846-7 · External reference
10.1038/s41467-024-49028-z
10.1038/s41467-024-49028-z · External reference
Direct measurement of lipid membrane disruption connects kinetics and toxicity ofAβ42 aggregation
2020 · External reference
10.1038/nn.3697
10.1038/nn.3697 · External reference
Intravenous treatment with a molecular chaperone designed against β-amyloid toxicity improves Alzheimer’s disease pathology in mouse models
10.1016/j.ymthe.2022.08.010 · 2023 · External reference
Intravenous chaperone treatment of late-stage Alzheimer′s disease (AD) mouse model affects amyloid plaque load, reactive gliosis and AD-related genes
10.1038/s41398-024-03161-x · 2024 · External reference
Stability of Transmembrane Amyloid β-Peptide and Membrane Integrity Tested by Molecular Modeling of Site-Specific Aβ42 Mutations
10.1371/journal.pone.0078399 · 2013 · External reference
10.1038/nm1058
10.1038/nm1058 · External reference
10.1002/alz.12084
10.1002/alz.12084 · External reference
10.1111/j.1742-4658.2010.07568.x
10.1111/j.1742-4658.2010.07568.x · External reference
10.1111/j.1471-4159.2005.03407.x
10.1111/j.1471-4159.2005.03407.x · External reference
10.1074/jbc.m109.000208
10.1074/jbc.m109.000208 · External reference
10.1038/s41467-025-58335-y
10.1038/s41467-025-58335-y · External reference
10.1073/pnas.2220075121
10.1073/pnas.2220075121 · External reference
Accelerated Alzheimer’s Aβ-42 secondary nucleation chronologically visualized on fibril surfaces
2025 · External reference
Structural defects in amyloid-β fibrils drive secondary nucleation
10.1038/s41467-026-69377-1 · 2026 · External reference
10.1002/pro.5091
10.1002/pro.5091 · External reference
Smallest Secondary Nucleation Competent Aβ Aggregates Probed by an ATP-Independent Molecular Chaperone Domain
10.1021/acs.biochem.1c00003 · 2021 · External reference
10.1074/jbc.m111.329763
10.1074/jbc.m111.329763 · External reference
Misfolded protein oligomers: mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases
10.1186/s13024-023-00651-2 · 2024 · External reference
Off-pathway oligomers of α-synuclein and Aβ inhibit secondary nucleation of α-synuclein amyloid fibrils
10.1016/j.jmb.2025.169048 · 2025 · External reference
10.1186/s13195-017-0293-3
10.1186/s13195-017-0293-3 · External reference
Amyloid inhibition by molecular chaperones in vitro can be translated to Alzheimer’s pathology in vivo
10.1039/d3md00040k · 2023 · External reference
10.1016/j.cell.2010.02.016
10.1016/j.cell.2010.02.016 · External reference
10.1016/j.cell.2009.01.038
10.1016/j.cell.2009.01.038 · External reference
Molecular determinants of protein pathogenicity at the single-aggregate level
2025 · External reference
Role of pro-inflammatory cytokines released from microglia in Alzheimer’s disease
2015 · External reference
10.1093/braincomms/fcaa146
10.1093/braincomms/fcaa146 · External reference
10.1016/s0169-328x(97)00356-2
10.1016/s0169-328x(97)00356-2 · External reference
10.1007/s00401-013-1129-2
10.1007/s00401-013-1129-2 · External reference
Alzheimer’s Disease and the Amyloid-β Peptide
10.3233/jad-2010-1221 · 2010 · External reference
10.1038/s41380-021-01249-0)
10.1038/s41380-021-01249-0) · External reference
10.1021/cn900015v
10.1021/cn900015v · External reference
Identification of potent high-affinity secondary nucleation inhibitors of Aβ42 aggregation from an ultra-large chemical library using deep docking
2026 · External reference
Ultrasensitive measurement of Ca2+ influx into lipid vesicles induced by protein aggregates
10.1002/anie.201700966 · 2017 · External reference
10.1016/j.celrep.2017.11.057
10.1016/j.celrep.2017.11.057 · External reference
Amyloid β Ion Channels in a Membrane Comprising Brain Total Lipid Extracts
10.1021/acschemneuro.7b00006 · 2017 · External reference
The catalytic nature of protein aggregation
10.1063/1.5133635 · 2020 · External reference
10.1038/nprot.2016.010
10.1038/nprot.2016.010 · External reference
Quantitative Profiling of Nanoscopic Protein Aggregates Reveals Specific Fingerprint of TDP-43-Positive Assemblies in Motor Neuron Disease
10.1002/advs.202505484 · 2025 · External reference
Reproducible and scalable differentiation of highly pure cortical neurons from human induced pluripotent stem cells
10.1016/j.xpro.2023.102266 · 2023 · External reference
10.1038/s41380-024-02746-8
10.1038/s41380-024-02746-8 · External reference