Research graph
References from Transient tubular membrane injury is converted into persistent fibrosis through a macrophage–fibroblast relay. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1038/s41581-026-01115-8
10.1038/s41581-026-01115-8 · External reference
10.1016/j.ebiom.2024.105294
10.1016/j.ebiom.2024.105294 · External reference
10.1038/s41467-024-51186-z
10.1038/s41467-024-51186-z · External reference
10.1126/sciimmunol.add8945
10.1126/sciimmunol.add8945 · External reference
10.1016/j.celrep.2023.112131
10.1016/j.celrep.2023.112131 · External reference
Depleting profibrotic macrophages using bioactivated in vivo assembly peptides ameliorates kidney fibrosis
10.1038/s41423-024-01190-6 · 2024 · External reference
10.3389/fmed.2024.1434535
10.3389/fmed.2024.1434535 · External reference
Infiltrative classical monocyte-derived and SPP1 lipid-associated macrophages mediate inflammation and fibrosis in ANCA-associated glomerulonephritis
10.1093/ndt/gfae292 · 2025 · External reference
10.1074/jbc.ra118.002352
10.1074/jbc.ra118.002352 · External reference
10.1002/glia.23953
10.1002/glia.23953 · External reference
Engineering of phosphatidylserine-targeting ROS-responsive polymeric prodrug for the repair of ischemia-reperfusion-induced acute kidney injury
10.1016/j.jconrel.2024.10.063 · 2024 · External reference
Diannexin protects against renal ischemia reperfusion injury and targets phosphatidylserines in ischemic tissue
10.1371/journal.pone.0024276 · 2011 · External reference
TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice
10.1038/s41419-024-06756-w · 2024 · External reference
An adoptive cell therapy with TREM2-overexpressing macrophages mitigates the transition from acute kidney injury to chronic kidney disease
10.1002/ctm2.70252 · 2025 · External reference
10.1016/j.cell.2019.05.031
10.1016/j.cell.2019.05.031 · External reference
10.1038/nmeth.4463
10.1038/nmeth.4463 · External reference
10.1038/s41467-021-21246-9
10.1038/s41467-021-21246-9 · External reference
10.1038/s41588-024-01802-x
10.1038/s41588-024-01802-x · External reference
Identification of a Novel ECM Remodeling Macrophage Subset in AKI to CKD Transition by Integrative Spatial and Single-Cell Analysis
10.1002/advs.202309752 · 2024 · External reference
Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis
10.1038/s44161-023-00354-3 · 2023 · External reference
TREM2 promotes lung fibrosis via controlling alveolar macrophage survival and pro-fibrotic activity
10.1038/s41467-025-57024-0 · 2025 · External reference
TREM2 in Macrophages Promotes Renal Fibrosis via Activation of beta-Catenin Signalling Pathway in Obstructive Nephropathy
10.1111/cpr.70192 · 2026 · External reference
10.1016/j.trsl.2024.10.002
10.1016/j.trsl.2024.10.002 · External reference
Macrophage STING signaling promotes fibrosis in benign airway stenosis via an IL6-STAT3 pathway
10.1038/s41467-024-55170-5 · 2025 · External reference
TRAP5 Inhibition Targeting Scar-Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition
10.1002/advs.202519855 · 2026 · External reference
Kidney fibrosis molecular mechanisms Spp1 influences fibroblast activity through transforming growth factor beta smad signaling
10.1016/j.isci.2024.109839 · 2024 · External reference
A dual alphavbeta1/alphavbeta6 integrin inhibitor Bexotegrast (PLN-74809) ameliorates organ injury and fibrogenesis in fibrotic kidney disease
10.1016/j.ejphar.2024.176983 · 2024 · External reference
10.1038/s41467-024-44886-z
10.1038/s41467-024-44886-z · External reference
The c-Abl-RACK1-FAK signaling axis promotes renal fibrosis in mice through regulating fibroblast-myofibroblast transition
10.1186/s12964-024-01603-z · 2024 · External reference
10.3390/cells15121102
10.3390/cells15121102 · External reference
