Research graph
References from Methylation-associated Gene Expression (MaGE): a non-invasive, in vivo measure of cellular senescence. Local targets link to admitted publications; unresolved targets remain external evidence.
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10.1016/0014-4827(61)90192-6 · External reference
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NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health
2022 · External reference
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P16INK4aexpression after chemotherapy in older women with early-stage breast cancer
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Chemotherapy and Stem Cell Transplantation Increase p16INK4a Expression, a Biomarker of T-cell Aging
10.1016/j.ebiom.2016.08.029 · 2016 · External reference
10.1002/cncr.33112
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A biomarker of aging, p16, predicts peripheral neuropathy in women receiving adjuvant taxanes for breast cancer
2022 · External reference
10.1093/gerona/glad214
10.1093/gerona/glad214 · External reference
Does walking during chemotherapy impact p16INK4a levels in women with early breast cancer
10.1002/jcla.24753 · 2022 · External reference
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An unbiased comparison of 14 epigenetic clocks in relation to 174 incident disease outcomes
2025 · External reference
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Epigenetic risk score improves prostate cancer risk assessment
10.1002/pros.23385 · 2017 · External reference
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10.1186/s13148-020-00903-8
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Creating and Validating a DNA Methylation-Based Proxy for Interleukin-6
2021 · External reference
Epigenetic scores for the circulating proteome as tools for disease prediction
10.7554/elife.71802 · 2022 · External reference
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Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health
2024 · External reference
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10.18632/aging.100908
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10.18632/aging.101414
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10.7554/elife.73420 · External reference
DNA methylation GrimAge version 2
2022 · External reference
10.1038/s43587-023-00557-0
10.1038/s43587-023-00557-0 · External reference
Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection
2022 · External reference
Host methylation predicts SARS-CoV-2 infection and clinical outcome
2021 · External reference
10.1053/j.gastro.2019.01.270
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10.1038/s44318-025-00601-2
10.1038/s44318-025-00601-2 · External reference
Targeted clearance of p21-but not p16-positive senescent cells prevents radiation-induced osteoporosis and increased marrow adiposity
10.1111/acel.13602 · 2022 · External reference
10.1016/j.cmet.2024.07.006
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Longitudinal paired liver biopsies and transcriptome profiling in alcohol-associated hepatitis reveal dynamic changes in cellular senescence
2025 · External reference
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10.1038/ncomms14532 · External reference
Digital quantification of p16-positive foci in fibrotic interstitial lung disease is associated with a phenotype of idiopathic pulmonary fibrosis with reduced survival
2022 · External reference
Biomarkers of cellular senescence and risk of death in humans
10.1111/acel.14006 · 2023 · External reference
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2025 · External reference
A chronological map of 308 physical and mental health conditions from 4 million individuals in the English National Health Service
10.1016/s2589-7500(19)30012-3 · 2019 · External reference
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Probabilistic inference of epigenetic age acceleration from cellular dynamics
2024 · External reference
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10.1038/s41588–019–0530–8 · External reference
Associations of biomarkers of cellular senescence with physical and cognitive function among older women with or without a history of premenopausal bilateral oophorectomy
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