Research graph
References from Folate metabolism in tumor-associated macrophages drives immunosuppressive function to promote tumor growth. Local targets link to admitted publications; unresolved targets remain external evidence.
Innate immune checkpoint inhibitor resistance is associated with melanoma sub-types exhibiting invasive and de-differentiated gene expression signatures
10.3389/fimmu.2022.955063 · 2022 · External reference
Utility of [99mTc]Tc-tilmanocept, an immunosuppressive macrophage functional imaging agent in melanoma patients receiving checkpoint inhibitor treatment: a feasibility study
10.1007/s00262-025-04127-8 · 2025 · External reference
Reprogramming of tumor-associated macrophages by metabolites generated from tumor microenvironment
10.1080/19768354.2024.2336249 · 2024 · External reference
Serine metabolism orchestrates macrophage polarization by regulating the IGF1–p38 axis
10.1038/s41423-022-00925-7 · 2022 · External reference
10.1016/j.tem.2023.09.003
10.1016/j.tem.2023.09.003 · External reference
10.1016/j.cmet.2019.01.014
10.1016/j.cmet.2019.01.014 · External reference
10.1016/j.molcel.2019.06.039
10.1016/j.molcel.2019.06.039 · External reference
10.1016/j.cmet.2016.08.009
10.1016/j.cmet.2016.08.009 · External reference
10.1016/j.molimm.2012.11.012
10.1016/j.molimm.2012.11.012 · External reference
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External reference
GSK3β Inhibition Prevents Macrophage Reprogramming by High-Dose Methotrexate
2022 · External reference
Folate deficiency-induced oxidative stress and apoptosis are mediated via homocysteine-dependent overproduction of hydrogen peroxide and enhanced activation of NF-kappaB in human Hep G2 cells
10.1016/s0753-3322(01)00095-6 · 2001 · External reference
10.1038/nature13236
10.1038/nature13236 · External reference
10.1158/1535-7163.mct-20-0423
10.1158/1535-7163.mct-20-0423 · External reference
10.1016/j.cmet.2020.02.017
10.1016/j.cmet.2020.02.017 · External reference
NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications
10.1038/s41392-020-00326-0 · 2020 · External reference
10.1016/j.immuni.2025.07.012
10.1016/j.immuni.2025.07.012 · External reference
10.1155/2016/2795090
10.1155/2016/2795090 · External reference
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours
10.1038/s41586-025-09493-y · 2025 · External reference
10.1038/cr.2013.75
10.1038/cr.2013.75 · External reference
10.4049/jimmunol.2300209
10.4049/jimmunol.2300209 · External reference
10.4049/jimmunol.165.2.1013
10.4049/jimmunol.165.2.1013 · External reference
10.1146/annurev-nutr-072610-145133
10.1146/annurev-nutr-072610-145133 · External reference
10.1016/j.tem.2021.12.003
10.1016/j.tem.2021.12.003 · External reference
10.1038/13861
10.1038/13861 · External reference
10.1158/2326-6066.cir-22-0271
10.1158/2326-6066.cir-22-0271 · External reference
10.1016/j.cell.2022.02.021
10.1016/j.cell.2022.02.021 · External reference
10.1158/0008-5472.can-09-2050
10.1158/0008-5472.can-09-2050 · External reference
10.1189/jlb.0613345
10.1189/jlb.0613345 · External reference
10.18632/oncotarget.3739
10.18632/oncotarget.3739 · External reference
10.4049/jimmunol.1501878
10.4049/jimmunol.1501878 · External reference
10.3389/fimmu.2025.1638907
10.3389/fimmu.2025.1638907 · External reference
Folate receptor beta drives NLRP3 inflammasome activation and pyroptosis in macrophages independent of folate binding
10.1093/jimmun/vkag051 · 2026 · External reference
10.1038/s41401-026-01878-7
10.1038/s41401-026-01878-7 · External reference
Tumor-specific activation of folate receptor beta enables reprogramming of immune cells in the tumor microenvironment
10.3389/fimmu.2024.1354735 · 2024 · External reference
10.1158/0008-5472.can-20-1414
10.1158/0008-5472.can-20-1414 · External reference
10.1038/s41467-021-20893-2
10.1038/s41467-021-20893-2 · External reference
Folate Receptor Beta as a Direct and Indirect Target for Antibody-Based Cancer Immunotherapy
10.3390/ijms22115572 · 2021 · External reference
10.1007/s00262-009-0667-x
10.1007/s00262-009-0667-x · External reference
10.1158/1535-7163.mct-17-0688
10.1158/1535-7163.mct-17-0688 · External reference
10.1016/j.cell.2023.11.037
10.1016/j.cell.2023.11.037 · External reference
10.1016/j.cell.2018.10.038
10.1016/j.cell.2018.10.038 · External reference
A resource for whole-body gene expression map of human tissues based on integration of single cell and bulk transcriptomics
10.1186/s13059-025-03616-4 · 2025 · External reference
10.1126/science.1260419
10.1126/science.1260419 · External reference
10.1158/2159-8290.cd-22-0787
10.1158/2159-8290.cd-22-0787 · External reference
10.1038/s41591-023-02304-9
10.1038/s41591-023-02304-9 · External reference
10.1038/s41590-019-0312-6
10.1038/s41590-019-0312-6 · External reference
10.1038/s41467-021-21246-9
10.1038/s41467-021-21246-9 · External reference
ZEB2 is a master switch controlling the tumor-associated macrophage program
10.1016/j.ccell.2025.03.021 · 2025 · External reference
10.1038/nature25460
10.1038/nature25460 · External reference
10.1126/science.aav4011
10.1126/science.aav4011 · External reference
Mitochondrial ROS-induced ROS release: An update and review
10.1016/j.bbabio.2006.04.029 · 2006 · External reference
10.1074/jbc.m802812200
10.1074/jbc.m802812200 · External reference
10.1038/s41586-019-0969-x
10.1038/s41586-019-0969-x · External reference
Untargeted Metabolomics Analysis Reveals Potential Metabolic Targets in Gemcitabine-Treated Pancreatic Cancer Cells
10.3390/metabo16070471 · 2026 · External reference
Evaluating cannabidiol-induced liver injury with and without valproate using a three-dimensional human hepatocyte spheroid model
2025 · External reference
10.1038/s41587-021-01139-4
10.1038/s41587-021-01139-4 · External reference
