Research graph
References from TRIM21 licenses pancreatic acinar fate by modulating BiP phase state through VCP-dependent retrotranslocation. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1016/j.cell.2016.12.004
10.1016/j.cell.2016.12.004 · External reference
10.1053/j.gastro.2018.07.028
10.1053/j.gastro.2018.07.028 · External reference
10.1038/s41585-022-00649-3
10.1038/s41585-022-00649-3 · External reference
10.1016/j.molcel.2022.03.025
10.1016/j.molcel.2022.03.025 · External reference
Endoplasmic reticulum (ER) protein degradation by ER-associated degradation and ER-phagy
10.1016/j.tcb.2025.01.002 · 2025 · External reference
10.1038/s41580-020-0250-z
10.1038/s41580-020-0250-z · External reference
10.1073/pnas.1616060114
10.1073/pnas.1616060114 · External reference
The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis
10.1038/s41467-019-10824-7 · 2019 · External reference
ZDHHC9-mediated Bip/GRP78 S-palmitoylation inhibits unfolded protein response and promotes bladder cancer progression
10.1016/j.canlet.2024.217118 · 2024 · External reference
Targeting GRP78 suppresses oncogenic KRAS protein expression and reduces viability of cancer cells bearing various KRAS mutations
10.1016/j.neo.2022.100837 · 2022 · External reference
NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5
2023 · External reference
10.1038/s41388-021-01791-9
10.1038/s41388-021-01791-9 · External reference
10.1073/pnas.1519384112
10.1073/pnas.1519384112 · External reference
Aberrant phase separation drives membranous organelle remodeling and tumorigenesis
10.1016/j.molcel.2025.04.001 · 2025 · External reference
10.7554/elife.08961
10.7554/elife.08961 · External reference
Endoplasmic Reticulum Stress Induces Liquid-Liquid Phase Separation of GRP78 and Modulates Protein Aggregation Dynamics
10.1021/acssensors.5c00807 · 2025 · External reference
10.1002/advs.76761
10.1002/advs.76761 · External reference
10.1074/jbc.m113.528174
10.1074/jbc.m113.528174 · External reference
The E3-ome gene-centric compendium reveals the human E3 ligase landscape
10.1016/j.cell.2026.01.029 · 2026 · External reference
10.1093/database/bav117
10.1093/database/bav117 · External reference
TRIM21 Promotes Tumor Growth and Gemcitabine Resistance in Pancreatic Cancer by Inhibiting EPHX1-Mediated Arachidonic Acid Metabolism
10.1002/advs.202413674 · 2025 · External reference
Revealing Protein Aggregates under Thapsigargin-Induced ER Stress Using an ER-Targeted Thioflavin
10.1021/acssensors.9b00568 · 2019 · External reference
TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway
10.1038/s41467-019-14190-2 · 2020 · External reference
10.1080/15548627.2022.2164427
10.1080/15548627.2022.2164427 · External reference
10.1093/nar/gkae385
10.1093/nar/gkae385 · External reference
“Intrinsic disorder-protein modification-LLPS-tumor” regulatory axis: From regulatory mechanisms to precision medicine
10.1016/j.bbcan.2024.189242 · 2025 · External reference
10.1073/pnas.2405964121
10.1073/pnas.2405964121 · External reference
10.1158/1078-0432.ccr-23-1143
10.1158/1078-0432.ccr-23-1143 · External reference
10.1073/pnas.2303448120
10.1073/pnas.2303448120 · External reference
Stress-induced translocation of the endoplasmic reticulum chaperone GRP78/BiP and its impact on human disease and therapy
10.1073/pnas.2412246122 · 2025 · External reference
10.1016/j.ccr.2004.08.018
10.1016/j.ccr.2004.08.018 · External reference
10.1038/nchembio.1313
10.1038/nchembio.1313 · External reference
10.1016/j.molcel.2017.10.028
10.1016/j.molcel.2017.10.028 · External reference
10.1126/science.abf6548
10.1126/science.abf6548 · External reference
Homeostasis control in health and disease by the unfolded protein response
10.1038/s41580-024-00794-0 · 2025 · External reference
10.1038/nrgastro.2013.36
10.1038/nrgastro.2013.36 · External reference
10.1038/nrgastro.2017.12
10.1038/nrgastro.2017.12 · External reference
10.1073/pnas.0810097105
10.1073/pnas.0810097105 · External reference
miR-802 Suppresses Acinar-to-Ductal Reprogramming During Early Pancreatitis and Pancreatic Carcinogenesis
10.1053/j.gastro.2021.09.029 · 2022 · External reference
SKP2 promotes the metastasis of pancreatic ductal adenocarcinoma by suppressing TRIM21-mediated PSPC1 degradation
10.1016/j.canlet.2024.216733 · 2024 · External reference
10.3390/ijms25126690
10.3390/ijms25126690 · External reference
10.1136/gutjnl-2013-306347
10.1136/gutjnl-2013-306347 · External reference
10.1016/j.canlet.2021.05.021
10.1016/j.canlet.2021.05.021 · External reference
10.1038/s41467-026-75063-z
10.1038/s41467-026-75063-z · External reference
10.1038/s41467-023-39291-x
10.1038/s41467-023-39291-x · External reference
10.1016/j.immuni.2023.02.018
10.1016/j.immuni.2023.02.018 · External reference
10.1007/s00125-022-05669-7
10.1007/s00125-022-05669-7 · External reference
10.1038/s41596-020-0312-x
10.1038/s41596-020-0312-x · External reference
UXT chaperone prevents proteotoxicity by acting as an autophagy adaptor for p62-dependent aggrephagy
10.1038/s41467-021-22252-7 · 2021 · External reference
