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References from Synthetic inhibitors of pregnancy-associated plasma protein-A regulate IGF-1 signaling in vitro and in vivo. Local targets link to admitted publications; unresolved targets remain external evidence.
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10.1093/molbev/msaf319 · 2026 · External reference
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10.1074/jbc.m114.611665
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10.1074/jbc.m115.650143 · External reference
10.1074/jbc.m001384200
10.1074/jbc.m001384200 · External reference
Structural insights into the covalent regulation of PAPP-A activity by proMBP and STC2
10.1038/s41421-022-00502-2 · 2022 · External reference
10.1093/humupd/dmv054
10.1093/humupd/dmv054 · External reference
10.1210/endrev/bnad017
10.1210/endrev/bnad017 · External reference
10.1111/acel.12624
10.1111/acel.12624 · External reference
PAPP-A: a promising therapeutic target for healthy longevity
10.1111/acel.12564 · 2017 · External reference
10.1530/jme-17-0236
10.1530/jme-17-0236 · External reference
Pregnancy-associated plasma protein-A (PAPP-A) and cardiovascular disease
10.1016/j.ghir.2024.101625 · 2024 · External reference
Metalloproteinase PAPP-A regulation of IGF-1 contributes to polycystic kidney disease pathogenesis
10.1172/jci.insight.135700 · 2020 · External reference
Increased activity of the metalloproteinase PAPP-A promotes diabetes-induced glomerular hypertrophy
10.1016/j.metabol.2022.155218 · 2022 · External reference
Genetic and pharmacological inhibition of PAPP-A reduces bleomycin-induced pulmonary fibrosis in aged mice via reduced IGF signaling
2024 · External reference
10.1007/s12079-015-0259-9
10.1007/s12079-015-0259-9 · External reference
Drugging IGF-1R in cancer: New insights and emerging opportunities
10.1016/j.gendis.2022.03.002 · 2023 · External reference
10.1002/jcp.24217
10.1002/jcp.24217 · External reference
Pregnancy-associated plasma proteins and stanniocalcin-2 – novel players controlling IGF-I physiology
2020 · External reference
10.18632/oncotarget.1629
10.18632/oncotarget.1629 · External reference
Structure of the PAPP-A(BP5) complex reveals mechanism of substrate recognition
10.1038/s41467-022-33175-2 · 2022 · External reference
Phosphinic peptides, the first potent inhibitors of astacin, behave as extremely slow-binding inhibitors. Biochem
1998 · External reference
Phosphinic peptides as zinc metalloproteinase inhibitors
2004 · External reference
Phosphinic acid compounds in biochemistry, biology and medicine
10.2174/0929867003374831 · 2000 · External reference
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10.1373/clinchem.2006.080614 · External reference
10.1016/j.ab.2003.12.035
10.1016/j.ab.2003.12.035 · External reference
Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism
10.1038/s41467-022-33698-8 · 2022 · External reference
10.1042/bj20020831
10.1042/bj20020831 · External reference
Cryo-EM structure of human PAPP-A2 and mechanism of substrate recognition
2023 · External reference
10.1038/s41598-017-01687-3
10.1038/s41598-017-01687-3 · External reference
10.7554/elife.52322
10.7554/elife.52322 · External reference
10.1126/scisignal.aat2231
10.1126/scisignal.aat2231 · External reference
Calcium state-dependent regulation of epithelial cell quiescence by stanniocalcin 1a
10.3389/fcell.2021.662915 · 2021 · External reference
10.1016/j.bmc.2008.08.058
10.1016/j.bmc.2008.08.058 · External reference
10.1074/jbc.m607903200
10.1074/jbc.m607903200 · External reference
The proteinase PAPP-A has deep evolutionary roots outside of the IGF System
10.1093/gbe/evaf042 · 2025 · External reference
Stanniocalcin 1a regulates organismal calcium balance and survival by suppressing Trpv6 expression and inhibiting IGF signaling in zebrafish
10.3389/fendo.2023.1276348 · 2023 · External reference
Pregnancy associated plasma protein-A2 (PAPP-A2) and stanniocalcin-2 (STC2) but not PAPP-A are associated with circulating total IGF-1 in a human adult population
10.1038/s41598-024-52074-8 · 2024 · External reference
Inhibition of longevity regulator PAPP-A modulates tissue homeostasis via restraint of mesenchymal stromal cells
10.1111/acel.13313 · 2021 · External reference
The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn(2+) levels
10.1098/rsob.200137 · 2020 · External reference
10.1038/s41467-023-39031-1
10.1038/s41467-023-39031-1 · External reference
