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References from KRAS G12C Inhibition Remodels the Non-Small Cell Lung Cancer Surfaceome to Uncover Targetable Vulnerabilities. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1016/j.jtho.2026.103695
10.1016/j.jtho.2026.103695 · External reference
10.1056/nejmoa2103695
10.1056/nejmoa2103695 · External reference
10.1056/nejmoa2204619
10.1056/nejmoa2204619 · External reference
10.1016/s0140-6736(23)00221-0
10.1016/s0140-6736(23)00221-0 · External reference
10.1158/2159-8290.cd-21-0365
10.1158/2159-8290.cd-21-0365 · External reference
10.1038/s41586-021-04065-2
10.1038/s41586-021-04065-2 · External reference
Genomic landscape of clinically acquired resistance alterations in patients treated with KRASG12C inhibitors
10.1016/j.annonc.2025.01.020 · 2025 · External reference
10.1056/nejmoa2105281
10.1056/nejmoa2105281 · External reference
10.1016/j.ccell.2024.01.012
10.1016/j.ccell.2024.01.012 · External reference
10.1158/2159-8290.cd-23-0289
10.1158/2159-8290.cd-23-0289 · External reference
10.1158/2159-8290.cd-24-0421
10.1158/2159-8290.cd-24-0421 · External reference
10.1056/nejmoa1801005
10.1056/nejmoa1801005 · External reference
10.1056/nejmoa1606774
10.1056/nejmoa1606774 · External reference
10.1200/jco.2024.42.16_suppl.8512
10.1200/jco.2024.42.16_suppl.8512 · External reference
10.1016/j.jtho.2025.11.018
10.1016/j.jtho.2025.11.018 · External reference
Krascendo-170 Lung: A phase Ib/II study of divarasib + pembrolizumab ± platinum-based chemotherapy and pemetrexed in untreated KRAS G12C+advanced non-small cell lung cancer (NSCLC)
10.1200/jco.2024.42.16_suppl.tps8651 · 2024 · External reference
10.1158/2159-8290.cd-24-0708
10.1158/2159-8290.cd-24-0708 · External reference
10.7554/elife.31098
10.7554/elife.31098 · External reference
CD70 is a therapeutic target upregulated in EMT-associated EGFR tyrosine kinase inhibitor resistance
10.1016/j.ccell.2023.01.007 · 2023 · External reference
Lung adenocarcinoma surfaceome remodeling with EGFR inhibitors uncovers placental alkaline phosphatase as a target for combination therapy
10.1016/j.xcrm.2025.102513 · 2025 · External reference
10.1016/j.tem.2021.12.003
10.1016/j.tem.2021.12.003 · External reference
10.1016/j.ygyno.2007.11.020
10.1016/j.ygyno.2007.11.020 · External reference
Exploiting the folate receptor α in oncology
10.1038/s41571-020-0339-5 · 2020 · External reference
10.1016/j.ab.2004.12.026
10.1016/j.ab.2004.12.026 · External reference
10.1158/1535-7163.mct-14-1095
10.1158/1535-7163.mct-14-1095 · External reference
10.1200/jco.22.01900
10.1200/jco.22.01900 · External reference
10.1016/j.annonc.2021.02.017
10.1016/j.annonc.2021.02.017 · External reference
10.1016/j.neo.2016.11.002
10.1016/j.neo.2016.11.002 · External reference
Derivation of AZD5335, a Novel FRα-Targeted TOP1i-Loaded ADC, for the Treatment of FRα-Expressing Cancers
10.1158/1078-0432.ccr-25-1749 · 2025 · External reference
Luveltamab tazevibulin (STRO-002), an anti-folate receptor alpha (FolRα) antibody drug conjugate (ADC), safety and efficacy in a broad distribution of FolRα expression in patients with recurrent epithelial ovarian cancer (OC): Update of STRO-002-GM1 phase 1 dose expansion cohort
10.1200/jco.2023.41.16_suppl.5508 · 2023 · External reference
10.1158/1535-7163.mct-24-0649
10.1158/1535-7163.mct-24-0649 · External reference
10.1158/1078-0432.ccr-20-4740
10.1158/1078-0432.ccr-20-4740 · External reference
10.1158/2159-8290.cd-22-0158
10.1158/2159-8290.cd-22-0158 · External reference
10.1038/s41591-026-04537-w
10.1038/s41591-026-04537-w · External reference
10.1038/s41586-022-04928-2
10.1038/s41586-022-04928-2 · External reference
10.1126/science.ads0239
10.1126/science.ads0239 · External reference
10.1126/science.adk0775
10.1126/science.adk0775 · External reference
10.1093/nar/gku1267
10.1093/nar/gku1267 · External reference
10.1038/s41586-022-05575-3
10.1038/s41586-022-05575-3 · External reference
10.1126/science.adk0850
10.1126/science.adk0850 · External reference
10.1073/pnas.1808790115
10.1073/pnas.1808790115 · External reference
The Cancer Surfaceome Atlas integrates genomic, functional and drug response data to identify actionable targets
10.1038/s43018-021-00282-w · 2021 · External reference
10.1126/science.1260419
10.1126/science.1260419 · External reference
10.1126/science.aan2507
10.1126/science.aan2507 · External reference
10.1038/nature13385
10.1038/nature13385 · External reference
10.1016/j.cell.2020.06.013
10.1016/j.cell.2020.06.013 · External reference
10.1097/jto.0b013e31824de09c
10.1097/jto.0b013e31824de09c · External reference
Molecular determinants of sotorasib clinical efficacy in KRASG12C-mutated non-small-cell lung cancer
10.1038/s41591-025-03732-5 · 2025 · External reference
10.1111/j.1440-1843.2006.00800.x
10.1111/j.1440-1843.2006.00800.x · External reference
10.1038/s41388-021-02076-x
10.1038/s41388-021-02076-x · External reference
10.1038/s41467-023-44184-0
10.1038/s41467-023-44184-0 · External reference
10.1073/pnas.1906663116
10.1073/pnas.1906663116 · External reference
10.1016/j.celrep.2023.113286
10.1016/j.celrep.2023.113286 · External reference
10.1038/s41586-024-07113-9
10.1038/s41586-024-07113-9 · External reference
10.1042/bsr20170772
10.1042/bsr20170772 · External reference
Folic acid inhibits COLO-205 colon cancer cell proliferation through activating the FRα/c-SRC/ERK1/2/NFκB/TP53 pathway: in vitro and in vivo studies
10.1038/srep11187 · 2015 · External reference
Noncanonical function of folate through folate receptor 1 during neural tube formation
10.1038/s41467-024-45775-1 · 2024 · External reference
10.1242/dev.137315
10.1242/dev.137315 · External reference
10.1242/bio.041160
10.1242/bio.041160 · External reference
Xenopus laevis as a Model Organism for the Study of Spinal Cord Formation, Development, Function and Regeneration
10.3389/fncir.2017.00090 · 2017 · External reference
10.1038/nm.3336
10.1038/nm.3336 · External reference
10.1038/nature06251
10.1038/nature06251 · External reference
10.1101/gad.227413.113
10.1101/gad.227413.113 · External reference
10.1158/0008-5472.can-15-1141
10.1158/0008-5472.can-15-1141 · External reference
10.7554/elife.02313
10.7554/elife.02313 · External reference
10.1083/jcb.201202108
10.1083/jcb.201202108 · External reference
10.1172/jci191370
10.1172/jci191370 · External reference
10.1016/j.stem.2020.07.022
10.1016/j.stem.2020.07.022 · External reference
10.1128/mcb.00323-08
10.1128/mcb.00323-08 · External reference
Epigenetic suppression of E-cadherin expression by Snail2 during the metastasis of colorectal cancer
10.1186/s13148-018-0592-y · 2018 · External reference
Chronic IL-1β-induced inflammation regulates epithelial-to-mesenchymal transition memory phenotypes via epigenetic modifications in non-small cell lung cancer
10.1038/s41598-019-57285-y · 2020 · External reference
10.1038/onc.2010.234
10.1038/onc.2010.234 · External reference
10.1158/2159-8290.cd-19-1167
10.1158/2159-8290.cd-19-1167 · External reference
10.3389/fonc.2024.1380584/bibtex
10.3389/fonc.2024.1380584/bibtex · External reference
10.1158/2159-8290.cd-20-0187
10.1158/2159-8290.cd-20-0187 · External reference
10.1126/scisignal.aaw9450
10.1126/scisignal.aaw9450 · External reference
10.1158/2159-8290.cd-22-1420
10.1158/2159-8290.cd-22-1420 · External reference
10.1172/jci155523
10.1172/jci155523 · External reference
10.1126/scitranslmed.aaw7999
10.1126/scitranslmed.aaw7999 · External reference
Folate Receptor α Expression Level Correlates With Histologic Grade in Lung Adenocarcinoma
10.5858/arpa.2015-0431-oa · 2016 · External reference
10.1245/s10434-007-9755-3
10.1245/s10434-007-9755-3 · External reference
10.1038/s41586-019-1694-1
10.1038/s41586-019-1694-1 · External reference
10.1158/1535-7163.mct-20-0462
10.1158/1535-7163.mct-20-0462 · External reference
Antibody drug conjugates: in search of partners of choice
10.1016/j.trecan.2023.01.003 · 2023 · External reference
Safety and efficacy of mirvetuximab soravtansine, a folate receptor alpha (FRα)–targeting antibody-drug conjugate (ADC), in combination with pembrolizumab in patients with platinum-resistant ovarian cancer
10.1016/j.ygyno.2025.06.016 · 2025 · External reference
The next generation of antibody–drug conjugates
10.1038/s41591-026-04543-y · 2026 · External reference
Re-evaluating antibody drug conjugate linker stability: assessment, interpretation, and clinical translation
10.1016/j.annonc.2026.04.008 · 2026 · External reference
10.1136/gutjnl-2024-bsg.296
10.1136/gutjnl-2024-bsg.296 · External reference
Role of RAS signaling in ovarian cancer
10.12688/f1000research.126337.1 · 2022 · External reference
Folate-conjugated immunoglobulin targets melanoma tumor cells for NK cell effector functions
10.1097/cmr.0000000000000258 · 2016 · External reference
Targeting KRAS Inhibitor-Resistant Pancreatic Cancer with an MUC1-C Antibody-Drug Conjugate
10.1158/1078-0432.ccr-25-2333 · 2025 · External reference
Abstract LB127: A first-in-class bispecific ADC targeting FORL1 and MUC1 exhibits promising anti-tumor activity in a FOLR1low xenograft model
10.1158/1538-7445.am2024-lb127 · 2024 · External reference
10.1016/j.cell.2014.04.028
10.1016/j.cell.2014.04.028 · External reference
10.1158/2159-8290.cd-24-0177
10.1158/2159-8290.cd-24-0177 · External reference
10.1038/nmeth.1226
10.1038/nmeth.1226 · External reference
10.1093/nar/gkv007
10.1093/nar/gkv007 · External reference
10.1093/bioinformatics/bti270
10.1093/bioinformatics/bti270 · External reference
MaxQuant enables high peptide identification rates, individualized p
2008 · External reference
10.1021/pr101065j
10.1021/pr101065j · External reference
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10.1093/database/bau012
10.1093/database/bau012 · External reference
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10.1126/scisignal.adu7145
10.1126/scisignal.adu7145 · External reference
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10.1093/bioinformatics/btt627
10.1093/bioinformatics/btt627 · External reference
10.1002/pro.3978
10.1002/pro.3978 · External reference
10.1101/2021.06.16.448102
10.1101/2021.06.16.448102 · External reference
10.1021/acs.jmedchem.2c01438
10.1021/acs.jmedchem.2c01438 · External reference
10.1016/j.cell.2018.01.006
10.1016/j.cell.2018.01.006 · External reference
RAS-GTP Inhibition Overcomes Acquired Resistance to KRASG12C Inhibitors Mediated by Oncogenic and Wild-Type RAS Activation in Non–Small Cell Lung Cancer
10.1158/0008-5472.can-25-0600 · 2026 · External reference
10.1172/jci164413
10.1172/jci164413 · External reference
10.1038/s41467-024-51828-2
10.1038/s41467-024-51828-2 · External reference
The landscape of therapeutic vulnerabilities in EGFR inhibitor osimertinib drug tolerant persister cells
10.1038/s41698-022-00337-w · 2022 · External reference
A tyrosine kinase inhibitor-induced interferon response positively associates with clinical response in EGFR-mutant lung cancer
10.1038/s41698-021-00181-4 · 2021 · External reference
Single-Cell Analysis Reveals Transcriptomic Features of Drug-Tolerant Persisters and Stromal Adaptation in a Patient-Derived EGFR-Mutated Lung Adenocarcinoma Xenograft Model
10.1016/j.jtho.2022.12.003 · 2023 · External reference