Research graph
References from APOE4 reduction in vascular-associated fibroblasts decreases cerebral amyloid angiopathy and associated vascular dysfunction. Local targets link to admitted publications; unresolved targets remain external evidence.
Clinical Predictors of Severe Cerebral Amyloid Angiopathy and Influence of APOE Genotype in Persons With Pathologically Verified Alzheimer Disease
10.1001/jamaneurol.2014.681 · 2014 · External reference
Cerebral amyloid angiopathy and Alzheimer disease — one peptide, two pathways
10.1038/s41582-019-0281-2 · 2020 · External reference
Cerebral Amyloid Angiopathy-Related Transient Focal Neurologic Episodes
10.1212/wnl.0000000000012234 · 2021 · External reference
10.1161/01.str.18.2.311
10.1161/01.str.18.2.311 · External reference
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10.1007/s007020200068 · External reference
10.1161/01.str.27.8.1333
10.1161/01.str.27.8.1333 · External reference
10.1093/brain/awx047
10.1093/brain/awx047 · External reference
10.1152/ajpheart.00022.2002
10.1152/ajpheart.00022.2002 · External reference
10.1161/strokeaha.124.044293
10.1161/strokeaha.124.044293 · External reference
10.1126/science.1078259
10.1126/science.1078259 · External reference
10.1016/j.jalz.2011.05.2351
10.1016/j.jalz.2011.05.2351 · External reference
Isoform-specific binding of apolipoprotein E to beta-amyloid
10.1016/s0021-9258(17)31529-6 · 1994 · External reference
10.1073/pnas.050004797
10.1073/pnas.050004797 · External reference
10.1073/pnas.1220484110
10.1073/pnas.1220484110 · External reference
10.1073/pnas.90.5.1977
10.1073/pnas.90.5.1977 · External reference
10.1016/0006-8993(91)91092-f
10.1016/0006-8993(91)91092-f · External reference
10.1038/ng1197-263
10.1038/ng1197-263 · External reference
10.1002/1531-8249(200006)47:6<739::aid-ana6>3.0.co;2-8
10.1002/1531-8249(200006)47:6<739::aid-ana6>3.0.co;2-8 · External reference
Comparison of the ApoE allelic variants in the formation of intracerebral Aβ deposits
10.1016/j.nbd.2025.107105 · 2025 · External reference
10.1126/scitranslmed.abd7522
10.1126/scitranslmed.abd7522 · External reference
APOE Antibody Inhibits Aβ-Associated Tau Seeding and Spreading in a Mouse Model
10.1002/ana.26351 · 2022 · External reference
Deciphering the role of APOE in cerebral amyloid angiopathy: from genetic insights to therapeutic horizons
10.1080/07853890.2024.2445194 · 2025 · External reference
10.1038/s41586-020-2247-3
10.1038/s41586-020-2247-3 · External reference
Amyloid-beta antibody binding to cerebral amyloid angiopathy fibrils and risk for amyloid-related imaging abnormalities
10.1038/s41598-024-61691-2 · 2024 · External reference
Amyloid-Related Imaging Abnormalities in 2 Phase 3 Studies Evaluating Aducanumab in Patients With Early Alzheimer Disease
10.1001/jamaneurol.2021.4161 · 2022 · External reference
10.1056/nej-moa2212948
10.1056/nej-moa2212948 · External reference
10.1523/jneurosci.21-03-00812.2001
10.1523/jneurosci.21-03-00812.2001 · External reference
10.1101/cshperspect.a006312
10.1101/cshperspect.a006312 · External reference
10.1016/j.immuni.2017.08.008
10.1016/j.immuni.2017.08.008 · External reference
10.1038/s41583-023-00776-9
10.1038/s41583-023-00776-9 · External reference
10.1016/j.jlr.2026.101000
10.1016/j.jlr.2026.101000 · External reference
Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy
10.1186/s13024-023-00610-x · 2023 · External reference
10.1038/s41586-021-04369-3
10.1038/s41586-021-04369-3 · External reference
10.1038/nature25739
10.1038/nature25739 · External reference
10.1186/s40478-015-0250-y
10.1186/s40478-015-0250-y · External reference
10.1038/s41583-021-00525-w
10.1038/s41583-021-00525-w · External reference
10.1016/s0002-9440(10)61108-x
10.1016/s0002-9440(10)61108-x · External reference
Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques
1996 · External reference
10.1016/j.immuni.2017.08.008
10.1016/j.immuni.2017.08.008 · External reference
10.1084/jem.20171265
10.1084/jem.20171265 · External reference
10.1016/j.biopsych.2017.03.003
10.1016/j.biopsych.2017.03.003 · External reference
10.1038/s41583-019-0201-x
10.1038/s41583-019-0201-x · External reference
10.1073/pnas.0805453106
10.1073/pnas.0805453106 · External reference
10.1016/j.neuroimage.2017.01.049
10.1016/j.neuroimage.2017.01.049 · External reference
Core cerebrospinal fluid biomarker profile in cerebral amyloid angiopathy: A meta-analysis
2018 · External reference
High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy
1994 · External reference
Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease
10.1038/s41467-024-54779-w · 2024 · External reference
10.1016/j.celrep.2022.110961
10.1016/j.celrep.2022.110961 · External reference
Brain perivascular macrophages: current understanding and future prospects
2023 · External reference
10.1038/nrn3114
10.1038/nrn3114 · External reference
10.1038/s41586-022-05397-3
10.1038/s41586-022-05397-3 · External reference
10.1073/pnas.1015413108
10.1073/pnas.1015413108 · External reference
10.1111/j.1365-2990.2007.00926.x
10.1111/j.1365-2990.2007.00926.x · External reference
10.3389/fnagi.2019.00001
10.3389/fnagi.2019.00001 · External reference
10.1007/s00018-024-05277-1
10.1007/s00018-024-05277-1 · External reference
10.1523/jneurosci.1202-06.2006
10.1523/jneurosci.1202-06.2006 · External reference
Maternal inheritance suppresses CAA and amyloid plaques in 5xFAD (Tg7031)/APOE4 mice
10.1016/j.neuron.2025.08.008 · 2025 · External reference
10.1093/gigascience/giaa151
10.1093/gigascience/giaa151 · External reference
Unresolved reference
External reference
Purification of Mouse Brain Vessels
2015 · External reference
An improved method for physical separation of cerebral vasculature and parenchyma enables detection of blood-brain-barrier dysfunction
10.3390/neurosci2010004 · 2021 · External reference
Depth-variant deconvolution applied to widefield microscopy for rapid large-volume tissue imaging
10.1038/s42003-025-08992-y · 2025 · External reference
