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References from SpiE is a distinct gut microbial 4-cholesten-3-one 5β-reductase that acts with SpiR to convert cholesterol to coprostanol. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1038/nrmicro3552
10.1038/nrmicro3552 · External reference
Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration
10.1038/s41564-023-01560-2 · 2024 · External reference
10.1016/j.chom.2024.05.011
10.1016/j.chom.2024.05.011 · External reference
10.1002/jobm.3620330115
10.1002/jobm.3620330115 · External reference
Microbial Hydroxysteroid Dehydrogenases: From Alpha to Omega
10.3390/microorganisms9030469 · 2021 · External reference
SpiR is a gut microbial enzyme that drives cholesterol conversion
10.1038/s41467-026-70820-6 · 2026 · External reference
10.1038/s41467-025-61425-6
10.1038/s41467-025-61425-6 · External reference
Gut bacteria metabolize natural and synthetic steroid hormones via the reductive OsrABC pathway
10.1016/j.chom.2025.09.014 · 2025 · External reference
Cholesterol-reducing bacterium from human feces
10.1128/aem.34.4.355-362.1977 · 1977 · External reference
Unresolved reference
1897 · External reference
Cholesterol-to-Coprostanol Conversion by the Gut Microbiota: What We Know, Suspect, and Ignore
10.3390/microorganisms9091881 · 2021 · External reference
10.2169/internalmedicine1962.22.14
10.2169/internalmedicine1962.22.14 · External reference
Stock diet for colony production of germfree rats and mice
1969 · External reference
10.1016/0003-9861(59)90056-6
10.1016/0003-9861(59)90056-6 · External reference
10.1111/j.1699-0463.1990.tb05004.x
10.1111/j.1699-0463.1990.tb05004.x · External reference
10.1016/j.femsle.2004.10.042
10.1016/j.femsle.2004.10.042 · External reference
10.1016/j.chom.2020.05.013
10.1016/j.chom.2020.05.013 · External reference
10.1016/0039-128x(95)00173-n
10.1016/0039-128x(95)00173-n · External reference
Precursors of Coprosterol and the Bile Acids in the Animal Organism
10.1038/136474a0 · 1935 · External reference
10.1016/s0021-9258(18)71221-0
10.1016/s0021-9258(18)71221-0 · External reference
10.1001/jama.1897.02440240001001
10.1001/jama.1897.02440240001001 · External reference
10.1093/bioinformatics/btad215
10.1093/bioinformatics/btad215 · External reference
Clostridium scindens baiCD and baiH genes encode stereo-specific 7α/7β-hydroxy-3-oxo-Δ4-cholenoic acid oxidoreductases
2008 · External reference
10.64898/2025.12.29.696961
10.64898/2025.12.29.696961 · External reference
10.1074/jbc.m706185200
10.1074/jbc.m706185200 · External reference
The Progesterone 5β-Reductase/Iridoid Synthase Family: A Catalytic Reservoir for Specialized Metabolism across Land Plants
10.1021/acschembio.0c00220 · 2020 · External reference
10.1074/jbc.m202160200
10.1074/jbc.m202160200 · External reference
10.1111/j.1432-1033.1973.tb02968.x
10.1111/j.1432-1033.1973.tb02968.x · External reference
Pinpointing a Mechanistic Switch Between Ketoreduction and “Ene” Reduction in Short-Chain Dehydrogenases/Reductases
10.1002/ange.201603785 · 2016 · External reference
Two patterns of neutral steroid conversion in the feces of normal North Americans
1974 · External reference
10.3109/00365527709181701
10.3109/00365527709181701 · External reference
Mechanism of biohydrogenation of cholesterol to coprostanol by Eubacterium ATCC 21408
10.1016/0005-2760(74)90239-2 · 1974 · External reference
10.1021/acscatal.8b00624
10.1021/acscatal.8b00624 · External reference
Draft genome sequence of a family Acutalibacteraceae isolate, a human gut-derived cholesterol metabolizer
2026 · External reference
10.1038/s41586-021-03832-5
10.1038/s41586-021-03832-5 · External reference
10.1111/j.1472-765x.1995.tb00410.x
10.1111/j.1472-765x.1995.tb00410.x · External reference
Effects of Eubacterium coprostanoligenes and Lactobacillus on pH, Lipid Content, and Cholesterol of Fermented Pork and Mutton Sausage-Type Mixes
10.1111/j.1365-2621.1999.tb15937.x · 1999 · External reference
10.1093/bioinformatics/btu153
10.1093/bioinformatics/btu153 · External reference
GTDB release 10: a complete and systematic taxonomy for 715 230 bacterial and 17 245 archaeal genomes
10.1093/nar/gkaf1040 · 2026 · External reference
10.1093/bioinformatics/btu031
10.1093/bioinformatics/btu031 · External reference
OrthoFinder: improved phylogenetic orthology inference with enhanced accuracy and scalability
10.1038/s41592-026-03126-6 · 2026 · External reference
10.1038/s41467-022-34630-w
10.1038/s41467-022-34630-w · External reference
10.1093/nar/gky448
10.1093/nar/gky448 · External reference
10.1093/nargab/lqab075
10.1093/nargab/lqab075 · External reference
10.1093/molbev/msw046
10.1093/molbev/msw046 · External reference
10.1093/nar/gkae268
10.1093/nar/gkae268 · External reference
10.1093/nar/gkae1010
10.1093/nar/gkae1010 · External reference
10.1038/nbt.3988
10.1038/nbt.3988 · External reference
10.1093/bioinformatics/btz305
10.1093/bioinformatics/btz305 · External reference
10.1038/s41586-024-07487-w
10.1038/s41586-024-07487-w · External reference
10.1093/nar/gki524
10.1093/nar/gki524 · External reference
10.1038/s41587-023-01773-0
10.1038/s41587-023-01773-0 · External reference
10.1101/635029
10.1101/635029 · External reference
Bifidobacteria metabolize lactulose to optimize gut metabolites and prevent systemic infection in patients with liver disease
10.1038/s41564-023-01493-w · 2023 · External reference
Fecal Butyrate and Deoxycholic Acid Concentrations Correlate With Mortality in Patients With Liver Disease
10.1016/j.gastha.2025.100695 · 2025 · External reference
Fecal metabolite profiling identifies critically ill patients with increased 30-day mortality
10.1126/sciadv.adt1466 · 2025 · External reference
10.1016/j.chom.2023.11.016
10.1016/j.chom.2023.11.016 · External reference
10.5281/zenodo.21235981
10.5281/zenodo.21235981 · External reference
10.1093/bioinformatics/btp352
10.1093/bioinformatics/btp352 · External reference
10.1038/nmeth.1923
10.1038/nmeth.1923 · External reference
10.1186/s13059-019-1891-0
10.1186/s13059-019-1891-0 · External reference
10.7717/peerj.12198
10.7717/peerj.12198 · External reference
10.7717/peerj-cs.104
10.7717/peerj-cs.104 · External reference
