Research graph
References from Inhibitory Nectin-2/TIGIT interactions between CD163 + macrophages and CD8 + T cells in spatially defined immune niches associate with poor outcomes in neuroblastoma. Local targets link to admitted publications; unresolved targets remain external evidence.
Immunotherapy for pediatric solid tumors: overcoming biological barriers through rational multimodal combinations
2026 · External reference
News on immune checkpoint inhibitors as immunotherapy strategies in adult and pediatric solid tumors
10.1016/j.semcancer.2020.07.001 · 2022 · External reference
10.1200/jco.2009.27.0421
10.1200/jco.2009.27.0421 · External reference
10.1056/nejm198510313131802
10.1056/nejm198510313131802 · External reference
10.1016/s0140-6736(07)60983-0
10.1016/s0140-6736(07)60983-0 · External reference
10.3390/cancers12020309
10.3390/cancers12020309 · External reference
Advancing therapy for neuroblastoma
2022 · External reference
10.1056/nejmoa0911123
10.1056/nejmoa0911123 · External reference
10.1080/2162402x.2017.1320626
10.1080/2162402x.2017.1320626 · External reference
10.4161/2162402x.2014.989764
10.4161/2162402x.2014.989764 · External reference
Tumor infiltrating cytotoxic CD8 T-Cells predict clinical outcome of neuroblastoma in children
10.4103/ijmpo.ijmpo_78_17 · 2018 · External reference
10.3389/fimmu.2017.01473
10.3389/fimmu.2017.01473 · External reference
10.1056/nejmoa2210859
10.1056/nejmoa2210859 · External reference
GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/2 trial
10.1038/s41591-025-03874-6 · 2025 · External reference
10.1016/j.biopha.2026.119020
10.1016/j.biopha.2026.119020 · External reference
10.1016/s1470-2045(19)30671-0
10.1016/s1470-2045(19)30671-0 · External reference
10.1196/annals.1322.008
10.1196/annals.1322.008 · External reference
10.1007/s00262-004-0603-z
10.1007/s00262-004-0603-z · External reference
10.1016/j.celrep.2024.114804
10.1016/j.celrep.2024.114804 · External reference
10.1136/jitc-2022-004807
10.1136/jitc-2022-004807 · External reference
10.1016/j.xcrm.2022.100657
10.1016/j.xcrm.2022.100657 · External reference
Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy
10.1016/j.ccell.2023.12.008 · 2024 · External reference
10.1016/j.ejca.2020.11.014
10.1016/j.ejca.2020.11.014 · External reference
10.1016/j.ejca.2025.115263
10.1016/j.ejca.2025.115263 · External reference
10.1186/s13059-023-02907-y
10.1186/s13059-023-02907-y · External reference
10.2174/1389202921999200716103758
10.2174/1389202921999200716103758 · External reference
Spatial predictors of immunotherapy response in triple-negative breast cancer
2023 · External reference
10.1158/0008-5472.can-22-0363
10.1158/0008-5472.can-22-0363 · External reference
10.1038/s41467-024-55179-w
10.1038/s41467-024-55179-w · External reference
10.1074/jbc.m112.448126
10.1074/jbc.m112.448126 · External reference
10.1080/19420862.2023.2253788
10.1080/19420862.2023.2253788 · External reference
10.1371/journal.pone.0212443
10.1371/journal.pone.0212443 · External reference
10.1002/eji.202048753
10.1002/eji.202048753 · External reference
Characterization of the CD200 Receptor Family in Mice and Humans and Their Interactions with CD200
10.4049/jimmunol.171.6.3034 · 2003 · External reference
10.1016/j.xpro.2021.101034
10.1016/j.xpro.2021.101034 · External reference
Anti-PD-1 treatment response is associated with the influx of circulating myeloid and T-cell subsets into the metastatic melanoma tumor microenvironment
10.1038/s41416-025-03137-8 · 2025 · External reference
PENGUIN: A rapid and efficient image preprocessing tool for multiplexed spatial proteomics
10.1016/j.csbj.2024.10.048 · 2024 · External reference
10.1101/2025.04.28.651001
10.1101/2025.04.28.651001 · External reference
10.1109/tvcg.2019.2931299
10.1109/tvcg.2019.2931299 · External reference
GdClean: removal of Gadolinium contamination in mass cytometry data
10.1093/bioinformatics/btab537 · 2021 · External reference
10.1038/s41596-023-00881-0
10.1038/s41596-023-00881-0 · External reference
A stratification system for breast cancer based on basoluminal tumor cells and spatial tumor architecture
10.1016/j.ccell.2025.06.019 · 2025 · External reference
10.1038/s41588-025-02158-6
10.1038/s41588-025-02158-6 · External reference
10.1158/2326-6066.cir-18-0507
10.1158/2326-6066.cir-18-0507 · External reference
10.1073/pnas.1121623109
10.1073/pnas.1121623109 · External reference
10.1038/s41591-021-01625-x
10.1038/s41591-021-01625-x · External reference
10.1158/0008-5472.can-21-1237
10.1158/0008-5472.can-21-1237 · External reference
10.1158/0008-5472.can-21-0691
10.1158/0008-5472.can-21-0691 · External reference
10.1016/j.intimp.2016.01.023
10.1016/j.intimp.2016.01.023 · External reference
10.1200/jco.2011.40.9169
10.1200/jco.2011.40.9169 · External reference
10.1186/s13073-026-01622-0
10.1186/s13073-026-01622-0 · External reference
10.1136/jitc-2025-012860
10.1136/jitc-2025-012860 · External reference
10.1111/imcb.12594
10.1111/imcb.12594 · External reference
10.3389/fimmu.2020.595297
10.3389/fimmu.2020.595297 · External reference
10.1002/eji.201646837
10.1002/eji.201646837 · External reference
10.1093/intimm/dxac024
10.1093/intimm/dxac024 · External reference
10.1038/s41422-020-0277-x
10.1038/s41422-020-0277-x · External reference
10.1016/j.cell.2018.11.043
10.1016/j.cell.2018.11.043 · External reference
10.1016/j.immuni.2016.10.021
10.1016/j.immuni.2016.10.021 · External reference
10.1016/j.immuni.2014.02.012
10.1016/j.immuni.2014.02.012 · External reference
Modulation of regulatory T cell function and stability by co-inhibitory receptors
10.1038/s41577-020-0296-3 · 2020 · External reference
10.1126/sciimmunol.aba7918
10.1126/sciimmunol.aba7918 · External reference
10.1038/s41586-019-1836-5
10.1038/s41586-019-1836-5 · External reference
Regulation of T cell exhaustion and stemness: molecular mechanisms and implications for cancer immunotherapy
2025 · External reference
10.1038/s41586-019-1324-y
10.1038/s41586-019-1324-y · External reference
10.64898/2026.06.10.26354144
10.64898/2026.06.10.26354144 · External reference
10.1136/jitc-2021-002417
10.1136/jitc-2021-002417 · External reference
10.1126/science.1129139
10.1126/science.1129139 · External reference
10.1038/nrc3245
10.1038/nrc3245 · External reference
10.1186/s40164-024-00543-1
10.1186/s40164-024-00543-1 · External reference
10.1016/j.ejca.2025.115708
10.1016/j.ejca.2025.115708 · External reference
10.1016/j.pharmthera.2022.108111
10.1016/j.pharmthera.2022.108111 · External reference
10.64898/2026.01.30.702794
10.64898/2026.01.30.702794 · External reference
Single-cell and spatial transcriptome characterize coinhibitory cell-cell communications during histological progression of lung adenocarcinoma
10.3389/fimmu.2024.1430163 · 2024 · External reference
10.1038/nm.3833
10.1038/nm.3833 · External reference
10.1038/s41423-024-01228-9
10.1038/s41423-024-01228-9 · External reference
10.1038/s41586-021-04057-2
10.1038/s41586-021-04057-2 · External reference
10.1101/2023.12.13.571595
10.1101/2023.12.13.571595 · External reference
10.2147/itt.s291767
10.2147/itt.s291767 · External reference
10.3389/fimmu.2023.1172681
10.3389/fimmu.2023.1172681 · External reference
10.1126/scitranslmed.add1834
10.1126/scitranslmed.add1834 · External reference
10.1016/j.ccr.2014.05.016
10.1016/j.ccr.2014.05.016 · External reference
10.1084/jem.20182124
10.1084/jem.20182124 · External reference
10.3390/pharmaceutics15041241
10.3390/pharmaceutics15041241 · External reference
10.1016/j.ccell.2025.11.009
10.1016/j.ccell.2025.11.009 · External reference
Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth
10.1016/j.ccell.2025.12.021 · 2026 · External reference
10.1038/s41589-026-02258-2
10.1038/s41589-026-02258-2 · External reference
10.3390/cancers15133317
10.3390/cancers15133317 · External reference
10.1186/s40425-019-0721-y
10.1186/s40425-019-0721-y · External reference
10.1038/s41419-025-08203-w
10.1038/s41419-025-08203-w · External reference
10.1038/s41467-025-67263-w
10.1038/s41467-025-67263-w · External reference
10.1038/s41590-024-02015-4
10.1038/s41590-024-02015-4 · External reference
10.1038/nbt.4195
10.1038/nbt.4195 · External reference
