Research graph
References from Isoindole-benzohydrazide derivative potentiates colistin activity to overcome resistance conferred by MCR-1 variants in Escherichia coli. Local targets link to admitted publications; unresolved targets remain external evidence.
Superbugs: An invisible threat in post antibiotic era
10.1016/j.cegh.2023.101499 · 2024 · External reference
10.3389/fphar.2023.1305294
10.3389/fphar.2023.1305294 · External reference
10.1038/d41586-024-03033-w
10.1038/d41586-024-03033-w · External reference
Emerging antibiotic resistance by various novel proteins/enzymes
10.1007/s10096-025-05126-4 · 2025 · External reference
10.32607/20758251-2018-10-4-33-48
10.32607/20758251-2018-10-4-33-48 · External reference
10.1016/j.molmed.2020.05.001
10.1016/j.molmed.2020.05.001 · External reference
10.1038/s41579-021-00650-4
10.1038/s41579-021-00650-4 · External reference
10.1038/s41579-022-00820-y
10.1038/s41579-022-00820-y · External reference
10.1016/j.addr.2005.04.002
10.1016/j.addr.2005.04.002 · External reference
10.1016/j.jmb.2019.04.002
10.1016/j.jmb.2019.04.002 · External reference
The Gram-negative permeability barrier: tipping the balance of the in and the out
10.1128/mbio.01205-23 · 2023 · External reference
An evolutionarily conserved mechanism for intrinsic and transferable polymyxin resistance
2018 · External reference
10.1128/msphere.00486-18
10.1128/msphere.00486-18 · External reference
A review of resistance to polymyxins and evolving mobile colistin resistance gene (mcr) among pathogens of clinical significance
10.3390/antibiotics12111597 · 2023 · External reference
A review on colistin resistance: an antibiotic of last resort
10.3390/microorganisms12040772 · 2024 · External reference
Colistin resistance in Acinetobacter baumannii: molecular mechanisms and epidemiology
10.3390/antibiotics12030516 · 2023 · External reference
10.3389/fmicb.2014.00643
10.3389/fmicb.2014.00643 · External reference
10.1007/s12038-021-00209-8
10.1007/s12038-021-00209-8 · External reference
Current update on intrinsic and acquired colistin resistance mechanisms in bacteria
10.3389/fmed.2021.677720 · 2021 · External reference
10.2147/idr.s199844
10.2147/idr.s199844 · External reference
Catalytic mechanism of the colistin resistance protein MCR-1
10.1039/d0ob02566f · 2021 · External reference
10.1128/msystems.01683-24
10.1128/msystems.01683-24 · External reference
Antibiotic adjuvants: a versatile approach to combat antibiotic resistance
10.1021/acsomega.3c00312 · 2023 · External reference
Antibiotic potentiators as a promising strategy for combating antibiotic resistance
10.1038/s44259-025-00112-4 · 2025 · External reference
New β-lactam/β-lactamase inhibitor combination antibiotics
10.3390/pathogens14040307 · 2025 · External reference
10.1038/s41467-018-02875-z
10.1038/s41467-018-02875-z · External reference
Design, synthesis and biological evaluation of 1-phenyl-2-(phenylamino) ethanone derivatives as novel MCR-1 inhibitors
10.3390/molecules24152719 · 2019 · External reference
High-throughput screening identification of apigenin that reverses the colistin resistance of mcr-1-positive pathogens
2024 · External reference
Pyrazolones potentiate colistin activity against MCR-1-producing resistant bacteria: computational and microbiological study
10.1021/acsomega.2c07165 · 2023 · External reference
Bithionol restores sensitivity of multidrug-resistant gram-negative bacteria to colistin with antimicrobial and anti-biofilm effects
10.1021/acsinfecdis.3c00257 · 2023 · External reference
A new variant of the colistin resistance gene MCR-1 with co-resistance to β-lactam antibiotics reveals a potential novel antimicrobial peptide
10.1371/journal.pbio.3002433 · 2023 · External reference
Computer-aided drug discovery and design: recent advances and future prospects
2024 · External reference
Recent advances in computer-aided drug design and drug discovery
10.3390/molecules31101606 · 2026 · External reference
10.1021/acs.jcim.2c01253
10.1021/acs.jcim.2c01253 · External reference
10.1038/s41467-021-22012-7
10.1038/s41467-021-22012-7 · External reference
Antibiotic-adjuvants abolish resistance conferred by the Staphylococcus aureus erythromycin resistance methyltransferase in an Escherichia coli model
10.1021/acsinfecdis.5c00865 · 2026 · External reference
Mechanistic basis of antimicrobial resistance mediated by the phosphoethanolamine transferase MCR-1
10.1038/s41467-025-65515-3 · 2025 · External reference
10.1021/acs.jcim.0c00675
10.1021/acs.jcim.0c00675 · External reference
10.1038/srep42717
10.1038/srep42717 · External reference
10.1038/nbt1284
10.1038/nbt1284 · External reference
10.1101/pdb.prot087163
10.1101/pdb.prot087163 · External reference
Colistin update on its mechanism of action and resistance, present and future challenges
10.3390/microorganisms8111716 · 2020 · External reference
10.7554/elife.65836
10.7554/elife.65836 · External reference
10.1093/jac/dki445
10.1093/jac/dki445 · External reference
10.3390/pharmaceutics16020170
10.3390/pharmaceutics16020170 · External reference
10.1089/adt.2011.0380
10.1089/adt.2011.0380 · External reference
Targeting dual substrate pockets of colistin resistance conferring MCR-1 of Escherichia coli with natural products: insights from high throughput virtual screening and molecular dynamics simulations
10.1080/07391102.2024.2445158 · 2025 · External reference
Deep Mutational Scanning Reveals the Active-Site Sequence Requirements for the Colistin Antibiotic Resistance Enzyme MCR-1
2021 · External reference
Unresolved reference
External reference
Welcome to the Tidyverse
10.21105/joss.01686 · 2019 · External reference
