Research graph
References from Activation of Disease-Associated Polycystin-1 Mutants by Binding of Stalk-derived Agonist Peptides. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1172/jci72272
10.1172/jci72272 · External reference
Autosomal dominant polycystic kidney disease
10.1016/s0140-6736(07)60601-1 · 2007 · External reference
Physiologic mechanisms underlying polycystic kidney disease
10.1152/physrev.00018.2024 · 2025 · External reference
Mechanistic insights into the pathogenesis of polycystic kidney disease
10.3390/cells14151203 · 2025 · External reference
10.1016/j.molmed.2023.01.005
10.1016/j.molmed.2023.01.005 · External reference
10.3389/fmolb.2022.1035507
10.3389/fmolb.2022.1035507 · External reference
A heteromeric TRP channel that functions as a WNT-activated G protein-coupled receptor
10.1038/s41467-026-69932-w · 2026 · External reference
10.1113/jp270933
10.1113/jp270933 · External reference
Intracellular calcium release modulates polycystin-2 trafficking
10.1186/1471-2369-14-34 · 2013 · External reference
10.1038/ng0697-179
10.1038/ng0697-179 · External reference
10.1073/pnas.94.13.6965
10.1073/pnas.94.13.6965 · External reference
10.1073/pnas.0903684106
10.1073/pnas.0903684106 · External reference
10.1038/ng1076
10.1038/ng1076 · External reference
10.1038/ncb3363
10.1038/ncb3363 · External reference
10.1126/science.aat9819
10.1126/science.aat9819 · External reference
10.15252/embr.201948336
10.15252/embr.201948336 · External reference
10.1056/nejmoa1205511
10.1056/nejmoa1205511 · External reference
10.1056/nejmoa1710030
10.1056/nejmoa1710030 · External reference
10.2215/cjn.17981120
10.2215/cjn.17981120 · External reference
Tolvaptan and autosomal dominant polycystic kidney disease
2017 · External reference
10.1172/jci64313
10.1172/jci64313 · External reference
Autosomal dominant polycystic kidney disease: genetics, mutations and microRNAs
2011 · External reference
10.1038/ki.2008.686
10.1038/ki.2008.686 · External reference
10.1172/jci67273
10.1172/jci67273 · External reference
10.1016/j.kint.2015.11.015
10.1016/j.kint.2015.11.015 · External reference
10.1016/j.molmed.2016.10.001
10.1016/j.molmed.2016.10.001 · External reference
10.1093/hmg/6.9.1483
10.1093/hmg/6.9.1483 · External reference
10.1021/bi035074c
10.1021/bi035074c · External reference
10.1006/bbrc.1998.9514
10.1006/bbrc.1998.9514 · External reference
10.1074/jbc.m201875200
10.1074/jbc.m201875200 · External reference
10.1074/jbc.m110483200
10.1074/jbc.m110483200 · External reference
10.1074/jbc.m402905200
10.1074/jbc.m402905200 · External reference
10.1152/physiolgenomics.00027.2016
10.1152/physiolgenomics.00027.2016 · External reference
The polycystin-1 C-type lectin domain binds carbohydrate in a calcium-dependent manner, and interacts with extracellular matrix proteins in vitro
2001 · External reference
10.1093/hmg/9.11.1641
10.1093/hmg/9.11.1641 · External reference
10.1016/s0014-5793(03)00130-3
10.1016/s0014-5793(03)00130-3 · External reference
10.7554/elife.60684
10.7554/elife.60684 · External reference
10.1016/s0960-9822(99)80379-0
10.1016/s0960-9822(99)80379-0 · External reference
10.1073/pnas.252484899
10.1073/pnas.252484899 · External reference
10.1128/mcb.00687-14
10.1128/mcb.00687-14 · External reference
10.1016/j.cellsig.2020.109637
10.1016/j.cellsig.2020.109637 · External reference
10.1016/j.tips.2013.06.002
10.1016/j.tips.2013.06.002 · External reference
10.1038/s41586-022-04619-y
10.1038/s41586-022-04619-y · External reference
10.1038/emboj.2012.26
10.1038/emboj.2012.26 · External reference
10.1038/s41586-022-04590-8
10.1038/s41586-022-04590-8 · External reference
10.1038/s41586-022-04580-w
10.1038/s41586-022-04580-w · External reference
10.1038/s41586-022-04575-7
10.1038/s41586-022-04575-7 · External reference
10.1073/pnas.1421785112
10.1073/pnas.1421785112 · External reference
Mechanism of Tethered Agonist Binding to an Adhesion G-Protein-Coupled Receptor
2025 · External reference
10.7554/elife.95992
10.7554/elife.95992 · External reference
10.1073/pnas.2113786119
10.1073/pnas.2113786119 · External reference
10.1016/j.jbc.2023.104674
10.1016/j.jbc.2023.104674 · External reference
10.1063/5.0021399
10.1063/5.0021399 · External reference
Gaussian accelerated molecular dynamics: unconstrained enhanced sampling and free energy calculation
10.1021/acs.jctc.5b00436 · 2015 · External reference
Improved reweighting of accelerated molecular dynamics simulations for free energy calculation
10.1021/ct500090q · 2014 · External reference
10.1093/nar/gky357
10.1093/nar/gky357 · External reference
10.1002/jcc.20945
10.1002/jcc.20945 · External reference
CHARMM36m: an improved force field for folded and intrinsically disordered proteins
10.1038/nmeth.4067 · 2017 · External reference
CHARMM additive and polarizable force fields for biophysics and computer-aided drug design
10.1016/j.bbagen.2014.08.004 · 2015 · External reference
10.1063/1.464397
10.1063/1.464397 · External reference
PTRAJ and CPPTRAJ: software for processing and analysis of molecular dynamics trajectory data
10.1021/ct400341p · 2013 · External reference
10.1016/0263-7855(96)00018-5
10.1016/0263-7855(96)00018-5 · External reference
10.1016/j.knosys.2019.06.032
10.1016/j.knosys.2019.06.032 · External reference
10.1101/2021.08.20.457171
10.1101/2021.08.20.457171 · External reference
Cyclic peptide structure prediction and design using AlphaFold2
10.1038/s41467-025-59940-7 · 2025 · External reference
Accurate de novo design of high-affinity protein-binding macrocycles using deep learning
10.1038/s41589-025-01929-w · 2025 · External reference
