Research graph
References from Rethinking Syndecan-1 as a Marker of Trauma-Induced Endothelial Injury. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1016/s0046-8177(87)80005-9
10.1016/s0046-8177(87)80005-9 · External reference
10.1186/s12967-015-0481-5
10.1186/s12967-015-0481-5 · External reference
10.1161/circresaha.124.325685
10.1161/circresaha.124.325685 · External reference
10.1007/s00441-021-03471-2
10.1007/s00441-021-03471-2 · External reference
10.3389/fcell.2024.1390794
10.3389/fcell.2024.1390794 · External reference
Injury induced endotheliopathy: overview, diagnosis, and management
2025 · External reference
Injury-induced endotheliopathy: What you need to know
10.1097/ta.0000000000004082 · 2023 · External reference
10.21203/rs.3.rs-9318157/v1
10.21203/rs.3.rs-9318157/v1 · External reference
10.1097/shk.0000000000001378
10.1097/shk.0000000000001378 · External reference
10.1097/shk.0000000000000999
10.1097/shk.0000000000000999 · External reference
10.1182/asheducation-2013.1.656
10.1182/asheducation-2013.1.656 · External reference
Hemorrhagic blood failure: Oxygen debt, coagulopathy, and endothelial damage
2017 · External reference
The glycocalyx: a central regulator of vascular function
10.1152/ajpregu.00340.2020 · 2021 · External reference
The endothelial glycocalyx: Structure and function in health and critical illness
10.1111/vec.12925 · 2020 · External reference
10.1111/aas.13797
10.1111/aas.13797 · External reference
10.1186/s13054-018-2292-6
10.1186/s13054-018-2292-6 · External reference
10.1111/bcp.12629
10.1111/bcp.12629 · External reference
Acute hyperglycemia exacerbates trauma-induced endothelial and glycocalyx injury: An in vitro model
10.1097/ta.0000000000001993 · 2018 · External reference
Shock induced endotheliopathy (SHINE) in acute critical illness - a unifying pathophysiologic mechanism
10.1186/s13054-017-1605-5 · 2017 · External reference
A biomimetic shock model on the effect of endothelial aging on vascular barrier properties
10.1097/ta.0000000000003207 · 2021 · External reference
Disparate effects of catecholamines under stress conditions on endothelial glycocalyx injury: An in vitro model
10.1016/j.amjsurg.2017.09.018 · 2017 · External reference
Effect on Syndecan-1 and Hyaluronan Levels Depending on Multiple Organ Failure, Coagulopathy and Survival: An Observational Study in Major Trauma Patients
10.3390/jcm13226768 · 2024 · External reference
10.1016/j.yexmp.2025.104997
10.1016/j.yexmp.2025.104997 · External reference
Association of endotheliopathy with coagulofibrinolytic reactions and disseminated intravascular coagulation after trauma: a retrospective observational study
10.1038/s41598-024-81123-5 · 2024 · External reference
Absences of Endothelial Microvesicle Changes in the Presence of the Endotheliopathy of Trauma
10.1097/shk.0000000000001149 · 2019 · External reference
10.1213/ane.0b013e318210385c
10.1213/ane.0b013e318210385c · External reference
10.1369/0022155420937087
10.1369/0022155420937087 · External reference
High molecular weight sodium hyaluronate improves survival of syndecan-1-deficient septic mice by inhibiting neutrophil migration
10.1371/journal.pone.0250327 · 2021 · External reference
The endothelial glycocalyx: a mechano-sensor and -transducer
2008 · External reference
10.1007/s10439-011-0429-8
10.1007/s10439-011-0429-8 · External reference
10.1073/pnas.1332808100
10.1073/pnas.1332808100 · External reference
Plasma Angiopoietin-2/-1 Ratio is Elevated and Angiopoietin-2 Levels Correlate With Plasma Syndecan-1 Following Pediatric Trauma
10.1097/shk.0000000000001267 · 2019 · External reference
10.1182/blood-2009-02-204966
10.1182/blood-2009-02-204966 · External reference
Shock-Driven Endotheliopathy in Trauma Patients Is Associated with Leucocyte Derived Extracellular Vesicles
10.3390/ijms232415990 · 2022 · External reference
Syndecan-1 as the Effect or Effector of the Endothelial Inflammatory Response?
10.1016/j.jss.2023.10.010 · 2024 · External reference
10.1097/ta.0b013e31825b5c10
10.1097/ta.0b013e31825b5c10 · External reference
Effect of transfusion of fresh frozen plasma on parameters of endothelial condition and inflammatory status in non-bleeding critically ill patients: a prospective substudy of a randomized trial
10.1186/s13054-015-0828-6 · 2015 · External reference
10.3389/fimmu.2022.991048
10.3389/fimmu.2022.991048 · External reference
Exploratory Investigation of the Plasma Proteome Associated with the Endotheliopathy of Trauma
10.3390/ijms23116213 · 2022 · External reference
10.1097/shk.0000000000000452
10.1097/shk.0000000000000452 · External reference
10.1097/sla.0b013e318226113d
10.1097/sla.0b013e318226113d · External reference
10.1097/shk.0000000000001432
10.1097/shk.0000000000001432 · External reference
10.1097/ta.0000000000000631
10.1097/ta.0000000000000631 · External reference
Circulating syndecans during critical illness
10.1111/apm.12662 · 2017 · External reference
Loss of Syndecan-1 Abrogates the Pulmonary Protective Phenotype Induced by Plasma After Hemorrhagic Shock
10.1097/shk.0000000000000832 · 2017 · External reference
Syndecan 1 plays a novel role in enteral glutamine’s gut-protective effects of the postischemic gut
10.1097/shk.0b013e31825a188a · 2012 · External reference
Fibrinogen Protects Against Barrier Dysfunction Through Maintaining Cell Surface Syndecan-1 In Vitro
10.1097/shk.0000000000001207 · 2019 · External reference
10.1371/journal.pone.0023530
10.1371/journal.pone.0023530 · External reference
Hemorrhagic shock drives glycocalyx, barrier and organ dysfunction early after polytrauma
10.1016/j.jcrc.2017.11.025 · 2018 · External reference
Traumatic brain injury is associated with increased syndecan-1 shedding in severely injured patients
10.1186/s13049-018-0565-3 · 2018 · External reference
Clinical value of syndecan-1 levels in trauma brain injury: A meta-analysis
10.1097/shk.0000000000002255 · 2024 · External reference
10.1097/shk.0000000000001940
10.1097/shk.0000000000001940 · External reference
Biomarkers of endothelial cell dysfunction persist beyond resuscitation in patients with hemorrhagic shock
10.1097/ta.0000000000003758 · 2022 · External reference
Acute Traumatic Endotheliopathy in Isolated Severe Brain Injury and Its Impact on Clinical Outcome
2018 · External reference
Experimental Models of Endotheliopathy: Impact of Shock Severity
10.1097/shk.0000000000000944 · 2018 · External reference
Syndecan-1: A Q;uantitative Marker for the Endotheliopathy of Trauma
10.1016/j.jamcollsurg.2017.05.012 · 2017 · External reference
Traumatic Endotheliopathy: A Prospective Observational Study of 424 Severely Injured Patients
10.1097/sla.0000000000001751 · 2017 · External reference
PAMPer study group: Prehospital plasma is associated with distinct biomarker expression following injury
10.1172/jci.insight.135350 · 2020 · External reference
10.3389/fmed.2022.985955
10.3389/fmed.2022.985955 · External reference
Endotheliopathy of trauma in children: The association of syndecan-1 with injury and poor outcomes
10.1097/ta.0000000000004229 · 2024 · External reference
Elevated Syndecan-1 after Trauma and Risk of Sepsis: A Secondary Analysis of Patients from the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial
10.1016/j.jamcollsurg.2018.09.003 · 2018 · External reference
Prehospital tranexamic acid is associated with a dose-dependent decrease in syndecan-1 after trauma: A secondary analysis of a prospective randomized trial
10.1097/ta.0000000000003955 · 2023 · External reference
Early Tranexamic Acid Administration After Traumatic Brain Injury Is Associated With Reduced Syndecan-1 and Angiopoietin-2 in Patients With Traumatic Intracranial Hemorrhage
10.1097/htr.0000000000000619 · 2020 · External reference
10.1097/shk.0b013e31829f91fc
10.1097/shk.0b013e31829f91fc · External reference
Decreased Glycocalyx Shedding on Presentation in Hemorrhaging Geriatric Trauma Patients
10.1016/j.jss.2023.09.047 · 2024 · External reference
Shock-Induced Endothelial Dysfunction is Present in Patients With Occult Hypoperfusion After Trauma
10.1097/shk.0000000000001866 · 2022 · External reference
Endothelial Dysfunction is Associated With Increased Incidence, Worsened Severity, and Prolonged Duration of Acute Kidney Injury After Severe Trauma
10.1097/shk.0000000000001638 · 2021 · External reference
Blood component resuscitative strategies to mitigate endotheliopathy in a murine hemorrhagic shock model
10.1097/ta.0000000000003942 · 2023 · External reference
Fresh frozen plasma attenuates lung injury in a novel model of prolonged hypotensive resuscitation
2020 · External reference
Trajectory of plasma syndecan-1 and heparan sulphate during major surgery: A retrospective observational study
10.1111/aas.14150 · 2023 · External reference
Circulating Syndecan-1 and Tissue Factor Pathway Inhibitor, Biomarkers of Endothelial Dysfunction, Predict Mortality in Burn Patients
10.1097/shk.0000000000001709 · 2021 · External reference
Syndecan-1 Levels in Trauma and Burn Patients Remain Elevated During Resuscitation and Correlate With Coagulopathy
10.1016/j.acepjo.2026.100350 · 2026 · External reference
10.1186/s12959-021-00308-4
10.1186/s12959-021-00308-4 · External reference
Acute respiratory distress syndrome, acute kidney injury, and mortality after trauma are associated with increased circulation of syndecan-1, soluble thrombomodulin, and receptor for advanced glycation end products
10.1097/ta.0000000000004096 · 2024 · External reference
10.1186/s13054-021-03545-1
10.1186/s13054-021-03545-1 · External reference
Endothelial damage occurs early after inhalation injury as measured by increased syndecan-1 levels
10.1093/jbcr/irad018 · 2023 · External reference
Plasma Ameliorates Endothelial Dysfunction in Burn Injury
10.1016/j.jss.2018.08.027 · 2019 · External reference
10.1016/j.burns.2019.05.009
10.1016/j.burns.2019.05.009 · External reference
Plasma biomarkers of endothelial function, inflammation and oxidative stress in individuals with non-freezing cold injury
10.1113/ep090722 · 2023 · External reference
Endothelial biomarkers as predictors for haemodialysis need in severe leptospirosis patients (Weil’s disease)
10.1111/tmi.13796 · 2022 · External reference
Markers of Endothelial Injury in Extracorporeal Membrane Oxygenation: A New Risk Assessment Method
10.1016/j.jss.2024.09.088 · 2024 · External reference
Endothelial dysfunction is dampened by early administration of fresh frozen plasma in a rodent burn shock model
10.1097/ta.0000000000004373 · 2024 · External reference
Association between sympathoadrenal activation, fibrinolysis, and endothelial damage in septic patients: a prospective study
10.1016/j.jcrc.2013.10.028 · 2014 · External reference
Longitudinal Assessment of Plasma Syndecan-1 Predicts 60-Day Mortality in Patients with COVID-19
10.3390/jcm12020552 · 2023 · External reference
10.1093/postmj/qgag053
10.1093/postmj/qgag053 · External reference
Resuscitation of Endotheliopathy and Bleeding in Thoracic Aortic Dissections: The VIPER-OCTA Randomized Clinical Pilot Trial
10.1213/ane.0000000000003545 · 2018 · External reference
Fibrinolytic dysfunction and endotheliopathy after major thermal injury: Considerations needed for new approaches to burn shock resuscitation
10.1097/shk.0000000000002473 · 2025 · External reference
10.3389/fonc.2026.1789000
10.3389/fonc.2026.1789000 · External reference
Biomarkers of Glycocalyx Injury are Associated with Delayed Cerebral Ischemia Following Aneurysmal Subarachnoid Hemorrhage: A Case Series Supporting a New Hypothesis
10.1007/s12028-016-0357-4 · 2017 · External reference
10.1164/rccm.201509-1878oc
10.1164/rccm.201509-1878oc · External reference
CD138 (syndecan-1) expression in health and disease
2014 · External reference
Syndecan-1: a key player in health and disease
2024 · External reference
Novel subgroups in acute respiratory failure based on the trajectories of three endotheliopathy biomarkers: A cohort study
10.1111/aas.14246 · 2023 · External reference
Pathophysiology-guided biomarkers and therapeutics for precision trauma medicine in polytrauma with musculoskeletal injuries
2026 · External reference
The expression of syndecan-1 and -2 is associated with Gleason score and epithelial-mesenchymal transition markers, E-cadherin and beta-catenin, in prostate cancer
10.1016/j.urolonc.2009.03.018 · 2010 · External reference
Cell surface-anchored syndecan-1 ameliorates intestinal inflammation and neutrophil transmigration in ulcerative colitis
10.1111/jcmm.12934 · 2017 · External reference
Stromal and epithelial syndecan-1 expression in benign and malignant salivary gland tumors: which is more reflective of behavior?
10.1016/j.bjorl.2019.07.006 · 2021 · External reference
10.7754/clin.lab.2021.210113
10.7754/clin.lab.2021.210113 · External reference
10.1146/annurev-immunol-041015-055354
10.1146/annurev-immunol-041015-055354 · External reference
10.1016/s1043-4666(03)00091-7
10.1016/s1043-4666(03)00091-7 · External reference
Syndecan-1 shedding destroys epithelial adherens junctions through STAT3 after renal ischemia/reperfusion injury
10.1016/j.isci.2023.108211 · 2023 · External reference
Unresolved reference
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10.1038/ki.2011.425
10.1038/ki.2011.425 · External reference
10.1159/000086969
10.1159/000086969 · External reference
Epithelial and stromal syndecan-1 and -2 are distinctly expressed in oral- and cutaneous squamous cell carcinomas
10.1111/jop.12025 · 2013 · External reference
10.1097/ta.0000000000003487
10.1097/ta.0000000000003487 · External reference
Unresolved reference
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Lung Gene Expression Analysis (LGEA): An integrative web portal for comprehensive gene expression analysis in lung development and disease
2021 · External reference
10.1038/s41467-023-40173-5
10.1038/s41467-023-40173-5 · External reference
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10.1038/ng.2653
10.1038/ng.2653 · External reference
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10.1126/science.add7046
10.1126/science.add7046 · External reference
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