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References from A chemical perturbation scan on a K 2P channel modulator pocket identifies affinity hotspots. Local targets link to admitted publications; unresolved targets remain external evidence.
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Membrane phospholipids control gating of the mechanosensitive potassium leak channel TREK1
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Cryo-EM structure of the human THIK-1 K2P K+ channel reveals a lower Y gate regulated by lipids and anesthetics
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Unresolved reference
External reference
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Atomistic mechanism of coupling between cytosolic sensor domain and selectivity filter in TREK K2P channels
10.1038/s41467-024-48823-y · 2024 · External reference
Development of covalent chemogenetic K2P channel activators
10.1016/j.chembiol.2024.06.006 · 2024 · External reference
Potassium dependent structural changes in the selectivity filter of HERG potassium channels
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Unresolved reference
External reference
