Research graph
References from AMPK Signalling Rewires WWP1 mediated RUNX1 Ubiquitination in CML Progression. Local targets link to admitted publications; unresolved targets remain external evidence.
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10.1038/sj.leu.2402766 · External reference
10.1038/sj.onc.1207779
10.1038/sj.onc.1207779 · External reference
RUNX1 upregulation and RUNX1-ETO depletion inhibits survival of t(8;21)-positive leukemia cells
10.1016/j.gmg.2026.100124 · 2026 · External reference
RUNX1-EVI1 disrupts lineage determination and the cell cycle by interfering with RUNX1 and EVI1 driven gene regulatory networks
2021 · External reference
10.1038/sj.onc.1208931
10.1038/sj.onc.1208931 · External reference
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10.1182/blood-2011-08-370981 · External reference
10.1038/onc.2014.305
10.1038/onc.2014.305 · External reference
10.1128/mcb.00597-06
10.1128/mcb.00597-06 · External reference
The ubiquitin ligase RNF38 promotes RUNX1 ubiquitination and enhances RUNX1-mediated suppression of erythroid transcription program
10.1016/j.bbrc.2018.10.006 · 2018 · External reference
10.1016/j.bbrc.2009.06.043
10.1016/j.bbrc.2009.06.043 · External reference
10.1074/jbc.m117.785675
10.1074/jbc.m117.785675 · External reference
10.1016/j.ccr.2008.06.001
10.1016/j.ccr.2008.06.001 · External reference
10.1038/s41419-023-06380-0
10.1038/s41419-023-06380-0 · External reference
The WWP1-JARID1B axis sustains acute myeloid leukemia chemoresistance
10.1073/pnas.2421159122 · 2025 · External reference
The E3 ubiquitin ligase WWP1 sustains the growth of acute myeloid leukaemia
10.1038/leu.2017.342 · 2018 · External reference
Thioredoxin-interacting protein (TXNIP) is a substrate of the NEDD4-like E3 ubiquitin-protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells
10.1002/1878-0261.13722 · 2025 · External reference
10.1016/j.molcel.2007.11.019
10.1016/j.molcel.2007.11.019 · External reference
AMPK-induced novel phosphorylation of RUNX1 inhibits STAT3 activation and overcome imatinib resistance in chronic myelogenous leukemia (CML) subjects
10.1038/s41420-023-01700-x · 2023 · External reference
10.1074/jbc.m405502200
10.1074/jbc.m405502200 · External reference
Metformin sensitizes clonally evolved imatinib–geldanamycin-resistant CML models through AMPK–HSF1 and AMPK–RUNX1 signaling
10.1016/j.celld.2026.100023 · 2026 · External reference
10.1523/jneurosci.4474-04.2005
10.1523/jneurosci.4474-04.2005 · External reference
10.1038/s41419-018-0791-7
10.1038/s41419-018-0791-7 · External reference
10.1126/science.1126313
10.1126/science.1126313 · External reference
10.1126/science.aau0159
10.1126/science.aau0159 · External reference
10.1016/j.tcb.2015.10.013
10.1016/j.tcb.2015.10.013 · External reference
Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics
10.1038/s41467-018-08004-0 · 2019 · External reference
10.1182/blood-2011-01-332783
10.1182/blood-2011-01-332783 · External reference
10.1172/jci200113505
10.1172/jci200113505 · External reference
Indole-3-carbinol protects against pressure overload induced cardiac remodeling via activating AMPK-α
10.1002/mnfr.201300012 · 2013 · External reference
Metformin, an Anti-diabetic Drug to Target Leukemia
10.3389/fendo.2018.00446 · 2018 · External reference
10.1136/ard.2007.078352
10.1136/ard.2007.078352 · External reference
10.1016/j.bbrc.2010.10.050
10.1016/j.bbrc.2010.10.050 · External reference
10.1038/sj.onc.1209924
10.1038/sj.onc.1209924 · External reference
10.1038/s41388-019-0955-7
10.1038/s41388-019-0955-7 · External reference
Role of MARCH E3 ubiquitin ligases in cancer development
10.1007/s10555-024-10201-x · 2024 · External reference
10.1186/1478-811x-11-52
10.1186/1478-811x-11-52 · External reference
Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation
10.1038/nmeth.2519 · 2013 · External reference
CYYR1 promotes the degradation of the E3 ubiquitin ligase WWP1 and is associated with favorable prognosis in breast cancer
10.1016/j.jbc.2024.107601 · 2024 · External reference
10.1074/jbc.m112.406009
10.1074/jbc.m112.406009 · External reference
10.1158/1078-0432.ccr-09-1225
10.1158/1078-0432.ccr-09-1225 · External reference
Indole-3-carbinol induces apoptosis of chronic myelogenous leukemia cells through suppression of STAT5 and Akt signaling pathways
2017 · External reference
10.1016/j.canlet.2014.01.006
10.1016/j.canlet.2014.01.006 · External reference
10.1158/1535-7163.mct-09-1186
10.1158/1535-7163.mct-09-1186 · External reference
10.1016/j.canlet.2008.01.033
10.1016/j.canlet.2008.01.033 · External reference
