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References from Defective neuronal differentiation in Lowe syndrome is associated with mitochondrial dysfunction and impaired cilia-related Sonic Hedgehog signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
ROS dynamics delineate functional states of hippocampal neural stem cells and link to their activity-dependent exit from quiescence
10.1016/j.stem.2020.10.019 · 2021 · External reference
Astrocytogenesis: where, when, and how
10.12688/f1000research.22405.1 · 2020 · External reference
Modeling the neuropsychiatric manifestations of Lowe syndrome using induced pluripotent stem cells: defective F-actin polymerization and WAVE-1 expression in neuronal cells
10.1186/s13229-018-0227-3 · 2018 · External reference
The oculocerebrorenal syndrome of Lowe: an update
10.1007/s00467-016-3343-3 · 2016 · External reference
Mouse model for Lowe syndrome/Dent Disease 2 renal tubulopathy
10.1681/asn.2010050565 · 2011 · External reference
Competence network for congenital heart defects investigators
10.1172/jci98890 · 2019 · External reference
Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease
10.3389/fncel.2014.00211 · 2014 · External reference
Astrocyte development in the cerebral cortex: Complexity of their origin, genesis, and maturation
10.3389/fnins.2022.916055 · 2022 · External reference
Exome sequencing of a patient with suspected mitochondrial disease reveals a likely multigenic etiology
10.1186/1471-2350-14-83 · 2013 · External reference
Lowe syndrome - Old and new evidence of secondary mitochondrial dysfunction
10.1016/j.ejmg.2020.104022 · 2020 · External reference
Reactive astrocyte nomenclature, definitions, and future directions
10.1038/s41593-020-00783-4 · 2021 · External reference
Astrocytes, neurons, synapses: a tripartite view on cortical circuit development
10.1186/s13064-018-0104-y · 2018 · External reference
New tricks for an old (hedge)hog: Sonic hedgehog regulation of astrocyte function
10.3390/cells10061353 · 2021 · External reference
A subpopulation of astrocyte progenitors defined by Sonic hedgehog signaling
10.1186/s13064-021-00158-w · 2022 · External reference
8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification
10.1038/s12276-022-00822-z · 2022 · External reference
Sonic hedgehog signaling in astrocytes mediates cell type-specific synaptic organization
10.7554/elife.45545 · 2019 · External reference
Sonic hedgehog signaling in astrocytes
10.1007/s00018-020-03668-8 · 2021 · External reference
Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy
10.1038/s41467-017-01859-9 · 2018 · External reference
Mitochondrial dysfunction compromises ciliary homeostasis in astrocytes
10.1083/jcb.202203019 · 2023 · External reference
Disrupting mitochondrial β-oxidation by depletion of HADHA impairs primary ciliogenesis
10.1038/s41598-025-18451-7 · 2025 · External reference
Lowe syndrome
1993 · External reference
OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome
10.1093/hmg/dds163 · 2012 · External reference
Lowe syndrome-linked endocytic adaptors direct membrane cycling kinetics with OCRL in Dictyostelium discoideum
10.1091/mbc.e18-08-0510 · 2019 · External reference
Reactive astrogliosis in the era of single-cell transcriptomics
10.3389/fncel.2023.1173200 · 2023 · External reference
Ion channels and electrophysiological properties of astrocytes: implications for emergent stimulation technologies
10.3389/fncel.2021.644126 · 2021 · External reference
The cellular and physiological functions of the Lowe syndrome protein OCRL1
10.1111/tra.12160 · 2014 · External reference
Mitochondrial impairment and intracellular reactive oxygen species alter primary cilia morphology
10.26508/lsa.202201505 · 2022 · External reference
Astrocyte alterations in neurodegenerative pathologies and their modeling in human induced pluripotent stem cell platforms
10.1007/s00018-019-03111-7 · 2019 · External reference
mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity
10.1016/j.cell.2022.08.018 · 2022 · External reference
Mitochondrial structure and function in OCRL depleted cells
10.3389/fcell.2025.1679675 · 2025 · External reference
Astrocytes dynamically regulate the blood-brain barrier in the healthy brain
10.4103/1673-5374.382248 · 2024 · External reference
Loss of OCRL increases ciliary PI(4,5)P2 in Lowe oculocerebrorenal syndrome
10.1242/jcs.200857 · 2017 · External reference
Identification of novel OCRL isoforms associated with phenotypic differences between Dent disease-2 and Lowe syndrome
10.1093/ndt/gfab274 · 2022 · External reference
Redox-dependent Igfbp2 signaling controls Brca1 DNA damage response to govern neural stem cell fate
10.1038/s41467-023-36174-z · 2023 · External reference
The role of the Lowe syndrome protein OCRL in the endocytic pathway
10.1515/hsz-2015-0180 · 2015 · External reference
Enhanced Notch dependent gliogenesis and delayed physiological maturation underlie neurodevelopmental defects in Lowe syndrome
10.1038/s44321-025-00327-y · 2025 · External reference
Mitochondrial DNA damage level determines neural stem cell differentiation fate
10.1523/jneurosci.0852-11.2011 · 2011 · External reference
Assessment of endocytic traffic and Ocrl function in the developing zebrafish neuroepithelium
10.1242/jcs.260339 · 2022 · External reference
Genomic analysis of reactive astrogliosis
10.1523/jneurosci.6221-11.2012 · 2012 · External reference
Rapid single-step induction of functional neurons from human pluripotent stem cells
10.1016/j.neuron.2013.05.029 · 2013 · External reference
Hedgehog pathway, cell cycle, and primary cilium
10.1038/s41420-025-02605-7 · 2025 · External reference
Imaging data associated with "Defective Neuronal Differentiation in Lowe Syndrome is Associated with Mitochondrial Dysfunction and Impaired Cilia-related Sonic Hedgehog Signaling"
2026 · External reference
Astrocyte alterations in neurodegenerative pathologies and their modeling in human induced pluripotent stem cell platforms
10.1007/s00018-019-03111-7 · ExternalCitation · doi-reference
Sonic hedgehog signaling in astrocytes
10.1007/s00018-020-03668-8 · ExternalCitation · doi-reference
The oculocerebrorenal syndrome of Lowe: an update
10.1007/s00467-016-3343-3 · ExternalCitation · doi-reference
mTOR-regulated mitochondrial metabolism limits mycobacterium-induced cytotoxicity
10.1016/j.cell.2022.08.018 · ExternalCitation · doi-reference
Lowe syndrome - Old and new evidence of secondary mitochondrial dysfunction
10.1016/j.ejmg.2020.104022 · ExternalCitation · doi-reference
Rapid single-step induction of functional neurons from human pluripotent stem cells
10.1016/j.neuron.2013.05.029 · ExternalCitation · doi-reference
ROS dynamics delineate functional states of hippocampal neural stem cells and link to their activity-dependent exit from quiescence
10.1016/j.stem.2020.10.019 · ExternalCitation · doi-reference
8-Oxoguanine: from oxidative damage to epigenetic and epitranscriptional modification
10.1038/s12276-022-00822-z · ExternalCitation · doi-reference
Hedgehog pathway, cell cycle, and primary cilium
10.1038/s41420-025-02605-7 · ExternalCitation · doi-reference
Loss of mtDNA activates astrocytes and leads to spongiotic encephalopathy
10.1038/s41467-017-01859-9 · ExternalCitation · doi-reference
Redox-dependent Igfbp2 signaling controls Brca1 DNA damage response to govern neural stem cell fate
10.1038/s41467-023-36174-z · ExternalCitation · doi-reference
Reactive astrocyte nomenclature, definitions, and future directions
10.1038/s41593-020-00783-4 · ExternalCitation · doi-reference
Disrupting mitochondrial β-oxidation by depletion of HADHA impairs primary ciliogenesis
10.1038/s41598-025-18451-7 · ExternalCitation · doi-reference
Enhanced Notch dependent gliogenesis and delayed physiological maturation underlie neurodevelopmental defects in Lowe syndrome
10.1038/s44321-025-00327-y · ExternalCitation · doi-reference
Mitochondrial dysfunction compromises ciliary homeostasis in astrocytes
10.1083/jcb.202203019 · ExternalCitation · doi-reference
Lowe syndrome-linked endocytic adaptors direct membrane cycling kinetics with OCRL in Dictyostelium discoideum
10.1091/mbc.e18-08-0510 · ExternalCitation · doi-reference
OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome
10.1093/hmg/dds163 · ExternalCitation · doi-reference
Identification of novel OCRL isoforms associated with phenotypic differences between Dent disease-2 and Lowe syndrome
10.1093/ndt/gfab274 · ExternalCitation · doi-reference
The cellular and physiological functions of the Lowe syndrome protein OCRL1
10.1111/tra.12160 · ExternalCitation · doi-reference
Competence network for congenital heart defects investigators
10.1172/jci98890 · ExternalCitation · doi-reference
Exome sequencing of a patient with suspected mitochondrial disease reveals a likely multigenic etiology
10.1186/1471-2350-14-83 · ExternalCitation · doi-reference
Astrocytes, neurons, synapses: a tripartite view on cortical circuit development
10.1186/s13064-018-0104-y · ExternalCitation · doi-reference
A subpopulation of astrocyte progenitors defined by Sonic hedgehog signaling
10.1186/s13064-021-00158-w · ExternalCitation · doi-reference
Modeling the neuropsychiatric manifestations of Lowe syndrome using induced pluripotent stem cells: defective F-actin polymerization and WAVE-1 expression in neuronal cells
10.1186/s13229-018-0227-3 · ExternalCitation · doi-reference
Loss of OCRL increases ciliary PI(4,5)P2 in Lowe oculocerebrorenal syndrome
10.1242/jcs.200857 · ExternalCitation · doi-reference
Assessment of endocytic traffic and Ocrl function in the developing zebrafish neuroepithelium
10.1242/jcs.260339 · ExternalCitation · doi-reference
Astrocytogenesis: where, when, and how
10.12688/f1000research.22405.1 · ExternalCitation · doi-reference
The role of the Lowe syndrome protein OCRL in the endocytic pathway
10.1515/hsz-2015-0180 · ExternalCitation · doi-reference
Mitochondrial DNA damage level determines neural stem cell differentiation fate
10.1523/jneurosci.0852-11.2011 · ExternalCitation · doi-reference
Genomic analysis of reactive astrogliosis
10.1523/jneurosci.6221-11.2012 · ExternalCitation · doi-reference
Mouse model for Lowe syndrome/Dent Disease 2 renal tubulopathy
10.1681/asn.2010050565 · ExternalCitation · doi-reference
Mitochondrial impairment and intracellular reactive oxygen species alter primary cilia morphology
10.26508/lsa.202201505 · ExternalCitation · doi-reference
Mitochondrial structure and function in OCRL depleted cells
10.3389/fcell.2025.1679675 · ExternalCitation · doi-reference
Astrocytic modulation of blood brain barrier: perspectives on Parkinson’s disease
10.3389/fncel.2014.00211 · ExternalCitation · doi-reference
Ion channels and electrophysiological properties of astrocytes: implications for emergent stimulation technologies
10.3389/fncel.2021.644126 · ExternalCitation · doi-reference
Reactive astrogliosis in the era of single-cell transcriptomics
10.3389/fncel.2023.1173200 · ExternalCitation · doi-reference
Astrocyte development in the cerebral cortex: Complexity of their origin, genesis, and maturation
10.3389/fnins.2022.916055 · ExternalCitation · doi-reference
New tricks for an old (hedge)hog: Sonic hedgehog regulation of astrocyte function
10.3390/cells10061353 · ExternalCitation · doi-reference
Astrocytes dynamically regulate the blood-brain barrier in the healthy brain
10.4103/1673-5374.382248 · ExternalCitation · doi-reference
Sonic hedgehog signaling in astrocytes mediates cell type-specific synaptic organization
10.7554/elife.45545 · ExternalCitation · doi-reference
