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References from Zinc is a key regulator of the sperm-specific K+ channel (Slo3) function. Local targets link to admitted publications; unresolved targets remain external evidence.
GROMACS 2023.3 source code
10.5281/zenodo.10017686 · 2023 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
The effect of zinc ions on fertilization of mouse ova in vitro
10.1530/jrf.0.0530179 · 1978 · External reference
Control of the low voltage-activated calcium channel of mouse sperm by egg ZP3 and by membrane hyperpolarization during capacitation
10.1073/pnas.96.12.6757 · 1999 · External reference
Observations on the penetration of the sperm in the mammalian egg
10.1071/bi9510581 · 1951 · External reference
Molecular dynamics with coupling to an external bath
10.1063/1.448118 · 1984 · External reference
Pressure control using stochastic cell rescaling
10.1063/5.0020514 · 2020 · External reference
Intracellular calcium regulation in sperm capacitation and acrosomal reaction
10.1016/s0303-7207(01)00704-3 · 2002 · External reference
SLO2 channels are inhibited by all divalent cations that activate SLO1 K+ channels
10.1074/jbc.m115.709436 · 2016 · External reference
Canonical sampling through velocity rescaling
10.1063/1.2408420 · 2007 · External reference
Fertilizing capacity of spermatozoa deposited into the fallopian tubes
10.1038/168697b0 · 1951 · External reference
Comparison of zinc concentrations in blood and seminal
10.1002/j.1939-4640.2000.tb03275.x · 2000 · External reference
Zinc-regulating proteins, ZnT-1, and metallothionein I/II are present in different cell populations in the mouse testis
10.1369/jhc.4a6482.2005 · 2005 · External reference
Zinc is an essential element for male fertility: A review of Zn roles in men’s health, germination, sperm quality, and fertilization
2018 · External reference
Four residues of the extracellular N-terminal domain of the NR2A subunit control high-affinity Zn2+ binding to NMDA receptors
10.1016/s0896-6273(00)81070-3 · 2000 · External reference
Intracellular zinc activates KCNQ channels by reducing their dependence on phosphatidylinositol 4,5-bisphosphate
10.1073/pnas.1620598114 · 2017 · External reference
Control of intracellular pH and bicarbonate by CO2 diffusion into human sperm
10.1038/s41467-023-40855-0 · 2023 · External reference
Relevance of zinc in human sperm flagella and its relation to motility
10.1016/s0015-0282(99)00141-7 · 1999 · External reference
Molecular aspects of declining sperm motility in older men
10.1016/j.fertnstert.2005.05.020 · 2005 · External reference
Zn2+ activates large conductance Ca2+-activated K+ channel via an intracellular domain
10.1074/jbc.m109.069211 · 2010 · External reference
Zinc activates damage-sensing TRPA1 ion channels
10.1038/nchembio.146 · 2009 · External reference
CHARMM36m: an improved force field for folded and intrinsically disordered proteins
10.1038/nmeth.4067 · 2017 · External reference
The action of reproductive fluids and contained steroids, prostaglandins, and Zn2+ on CatSper Ca2+ channels in human sperm
10.3389/fcell.2021.699554 · 2021 · External reference
Overview of mammalian zinc transporters
10.1007/s00018-003-3148-y · 2004 · External reference
Polarized PtdIns(4,5)P2 distribution mediated by a voltage-sensing phosphatase (VSP) regulates sperm motility
10.1073/pnas.1916867116 · 2019 · External reference
Zinc ion flux during mammalian sperm capacitation
10.1038/s41467-018-04523-y · 2018 · External reference
Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel
10.1038/nature04417 · 2006 · External reference
Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel
10.1073/pnas.1215078109 · 2012 · External reference
Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel
10.1016/j.cell.2009.12.053 · 2010 · External reference
A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function
10.1073/pnas.2212338120 · 2023 · External reference
Regulation of intracellular pH in eukaryotic cells
10.1042/bj2500001 · 1988 · External reference
Zinc biochemistry: from a single zinc enzyme to a key element of life
10.3945/an.112.003038 · 2013 · External reference
SPATA33 localizes calcineurin to the mitochondria and regulates sperm motility in mice
10.1073/pnas.2106673118 · 2021 · External reference
KSper, a pH-sensitive K + current that controls sperm membrane potential
10.1073/pnas.0702018104 · 2007 · External reference
High-affinity zinc inhibition of NMDA NR1-NR2A receptors
10.1523/jneurosci.17-15-05711.1997 · 1997 · External reference
[Ca2+]i signalling in sperm--making the most of what you’ve got
10.1038/ncb0307-235 · 2007 · External reference
Effect of zinc on human sperm motility and the acrosome reaction
10.1111/j.1365-2605.1992.tb01343.x · 1992 · External reference
The SLO3 sperm-specific potassium channel plays a vital role in male fertility
10.1016/j.febslet.2010.02.005 · 2010 · External reference
Voltage-dependent conformational changes in human Ca(2+)- and voltage-activated K(+) channel, revealed by voltage-clamp fluorometry
10.1073/pnas.0601176103 · 2006 · External reference
Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes
10.1074/jbc.273.6.3509 · 1998 · External reference
Chelation of intracellular zinc ions affects human sperm cell motility
10.1093/molehr/5.4.338 · 1999 · External reference
Zn2+ sensitivity of high- and low-voltage activated calcium channels
10.1529/biophysj.106.103333 · 2007 · External reference
In vitro fertilization of eggs by fresh epididymal sperm
10.1262/jrd1955.16.147 · 1971 · External reference
Zinc modulation of glycine receptors
10.1016/j.neuroscience.2011.04.021 · 2011 · External reference
The biochemical basis of zinc physiology
10.1152/physrev.1993.73.1.79 · 1993 · External reference
Intracellular pH of bovine sperm increases during capacitation
10.1002/mrd.1080400413 · 1995 · External reference
Ionic blockage of sodium channels in nerve
10.1085/jgp.61.6.687 · 1973 · External reference
CHARMM-GUI Membrane Builder toward realistic biological membrane simulations
10.1002/jcc.23702 · 2014 · External reference
Zinc is an essential trace element for spermatogenesis
10.1073/pnas.0900602106 · 2009 · External reference
LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel
10.1073/pnas.1111104108 · 2011 · External reference
Sperm membrane potential: hyperpolarization during capacitation regulates zona pellucida-dependent acrosomal secretion
10.1006/dbio.1995.1304 · 1995 · External reference
pH regulation in mouse sperm: identification of Na(+)-, Cl(-)-, and HCO3(-)-dependent and arylaminobenzoate-dependent regulatory mechanisms and characterization of their roles in sperm capacitation
10.1006/dbio.1996.0044 · 1996 · External reference
Deletion of the Slo3 gene abolishes alkalization-activated K+ current in mouse spermatozoa
10.1073/pnas.1100240108 · 2011 · External reference
SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility
10.1073/pnas.1423869112 · 2015 · External reference
Slo3 K+ channels: voltage and pH dependence of macroscopic currents
10.1085/jgp.200609552 · 2006 · External reference
Structural basis of human Slo2.2 channel gating and modulation
10.1016/j.celrep.2023.112858 · 2023 · External reference
Role of human Hv1 channels in sperm capacitation and white blood cell respiratory burst established by a designed peptide inhibitor
10.1073/pnas.1816189115 · 2018 · External reference
Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A
10.1038/nn0901-894 · 2001 · External reference
Zinc transporter ZIP12 maintains zinc homeostasis and protects spermatogonia from oxidative stress during spermatogenesis
10.1186/s12958-022-00893-7 · 2022 · External reference
MD simulations of Slo3 with Zn
10.5281/zenodo.19626536 · 2026 · External reference
potassium channel subfamily U member 1 [Mus musculus]
1998 · External reference
calcium-activated potassium channel subunit alpha-1 isoform 7 [Mus musculus]
1993 · External reference
potassium channel subfamily T member 1 isoform 2 [Mus musculus]
2003 · External reference
