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References from Cardiolipin deficiency disrupts electron transport chain and drives steatohepatitis. Local targets link to admitted publications; unresolved targets remain external evidence.
Molecular mechanism of cardiolipin-mediated assembly of respiratory chain supercomplexes
10.1039/c5sc04664e · 2016 · External reference
Cardiolipin-dependent reconstitution of respiratory supercomplexes from purified Saccharomyces cerevisiae complexes III and IV
10.1074/jbc.m112.425876 · 2013 · External reference
Molecular pathways of nonalcoholic fatty liver disease development and progression
10.1007/s00018-018-2947-0 · 2019 · External reference
Phosphatidylethanolamine and cardiolipin differentially affect the stability of mitochondrial respiratory chain supercomplexes
10.1016/j.jmb.2012.09.001 · 2012 · External reference
Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling
10.1016/j.freeradbiomed.2016.04.001 · 2016 · External reference
The multiple-hit pathogenesis of non-alcoholic fatty liver disease (NAFLD)
10.1016/j.metabol.2015.12.012 · 2016 · External reference
Dynamic shifts in the composition of resident and recruited macrophages influence tissue remodeling in NASH
10.1016/j.celrep.2020.108626 · 2021 · External reference
Mitochondrial membrane lipids in the regulation of bioenergetic flux
10.1016/j.cmet.2024.07.024 · 2024 · External reference
Mitochondrial oxidative injury: a key player in nonalcoholic fatty liver disease
10.1152/ajpgi.00121.2020 · 2020 · External reference
The mechanism of mitochondrial superoxide production by the cytochrome bc1 complex
10.1074/jbc.m803236200 · 2008 · External reference
Cardiolipin deficiency affects respiratory chain function and organization in an induced pluripotent stem cell model of Barth syndrome
10.1016/j.scr.2013.05.005 · 2013 · External reference
Changes in key mitochondrial lipids accompany mitochondrial dysfunction and oxidative stress in NAFLD
10.1155/2021/9986299 · 2021 · External reference
Mitochondrial adaptation in steatotic mice
10.1016/j.mito.2017.08.015 · 2018 · External reference
Role of diet and nutritional management in non-alcoholic fatty liver disease
10.1111/jgh.12244 · 2013 · External reference
Cardiolipin requirement for electron transfer in complex I and III of the mitochondrial respiratory chain
10.1016/s0021-9258(19)69888-1 · 1981 · External reference
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
10.1038/nature09968 · 2011 · External reference
Reign in the membrane: how common lipids govern mitochondrial function
10.1016/j.ceb.2020.01.006 · 2020 · External reference
Quantitative determination of cardiolipin in mitochondrial electron transferring complexes by silicic acid high-performance liquid chromatography
10.1006/abio.1998.2998 · 1999 · External reference
Cardiolipin deficiency in Barth syndrome is not associated with increased superoxide/H2 O2 production in heart and skeletal muscle mitochondria
10.1002/1873-3468.13973 · 2021 · External reference
Biomarkers of NAFLD progression: a lipidomics approach to an epidemic
10.1194/jlr.p056002 · 2015 · External reference
Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity
10.1126/sciadv.aax8352 · 2019 · External reference
Cardiolipin, the heart of mitochondrial metabolism
10.1007/s00018-008-8030-5 · 2008 · External reference
Cardiolipin remodeling by TAZ/tafazzin is selectively required for the initiation of mitophagy
10.1080/15548627.2015.1023984 · 2015 · External reference
Absence of cardiolipin in the crd1 null mutant results in decreased mitochondrial membrane potential and reduced mitochondrial function
10.1074/jbc.m909868199 · 2000 · External reference
Targeted overexpression of catalase to mitochondria does not prevent cardioskeletal myopathy in Barth syndrome
10.1016/j.yjmcc.2018.07.001 · 2018 · External reference
Mitochondrial phosphatidylethanolamine modulates UCP1 to promote brown adipose thermogenesis
10.1126/sciadv.ade7864 · 2023 · External reference
How cardiolipin modulates the dynamics of respiratory complex I
10.1126/sciadv.aav1850 · 2019 · External reference
Amplex red assay for measuring hydrogen peroxide production from Caenorhabditis elegans
10.21769/bioprotoc.3409 · 2019 · External reference
Lipidomics in non-alcoholic fatty liver disease
10.4254/wjh.v12.i8.436 · 2020 · External reference
Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis
10.1016/j.cmet.2015.04.004 · 2015 · External reference
Specific roles of protein-phospholipid interactions in the yeast cytochrome bc1 complex structure
10.1093/emboj/20.23.6591 · 2001 · External reference
Tafazzin deficiency impairs CoA-dependent oxidative metabolism in cardiac mitochondria
10.1074/jbc.ra119.011229 · 2020 · External reference
Mitochondrial dysfunction in the transition from NASH to HCC
10.3390/metabo9100233 · 2019 · External reference
Flow cytometric analysis of inflammatory and resident myeloid populations in mouse ocular inflammatory models
10.1016/j.exer.2016.08.007 · 2016 · External reference
Lipotoxicity and the gut-liver axis in NASH pathogenesis
10.1016/j.jhep.2017.11.014 · 2018 · External reference
Current status and future trends of the global burden of MASLD
10.1016/j.tem.2024.02.007 · 2024 · External reference
Cardiolipin-dependent formation of mitochondrial respiratory supercomplexes
10.1016/j.chemphyslip.2013.10.012 · 2014 · External reference
Carboxylesterase converts Amplex red to resorufin: Implications for mitochondrial H2O2 release assays
10.1016/j.freeradbiomed.2015.11.011 · 2016 · External reference
Pathogenesis of NASH: the impact of multiple pathways
10.1007/s11901-018-0425-7 · 2018 · External reference
Reactive oxygen species affect mitochondrial electron transport complex I activity through oxidative cardiolipin damage
10.1016/s0378-1119(01)00814-9 · 2002 · External reference
Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease
10.3748/wjg.v20.i39.14205 · 2014 · External reference
Role of cardiolipin in mitochondrial function and dynamics in health and disease: Molecular and pharmacological aspects
10.3390/cells8070728 · 2019 · External reference
Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease progression
10.1194/jlr.m085613 · 2018 · External reference
The role of cardiolipin concentration and acyl chain composition on mitochondrial inner membrane molecular organization and function
10.1016/j.bbalip.2019.03.012 · 2019 · External reference
Cardiolipin stabilizes respiratory chain supercomplexes
10.1074/jbc.m308366200 · 2003 · External reference
Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle
10.1126/sciadv.abd6322 · 2021 · External reference
Functional binding of cardiolipin to cytochrome c oxidase
10.1007/bf00762857 · 1993 · External reference
Characterization of hepatic lipid profiles in a mouse model with nonalcoholic steatohepatitis and subsequent fibrosis
10.1038/srep12466 · 2015 · External reference
Cardiolipin synthase from mammalian mitochondria
10.1016/s0005-2760(97)00119-7 · 1997 · External reference
The stability and activity of respiratory Complex II is cardiolipin-dependent
10.1016/j.bbabio.2012.04.015 · 2012 · External reference
Unresolved reference
2023 · External reference
Mitochondrial quality control: Its role in metabolic dysfunction-associated steatotic liver disease (MASLD)
10.7570/jomes23054 · 2023 · External reference
Mitochondria in non-alcoholic fatty liver disease
10.1016/j.biocel.2017.12.019 · 2018 · External reference
The alterations of mitochondrial function during NAFLD progression-an independent effect of mitochondrial ROS production
10.3390/ijms22136848 · 2021 · External reference
Sedentary behavior in mice induces metabolic inflexibility by suppressing skeletal muscle pyruvate metabolism
10.1172/jci167371 · 2024 · External reference
Mitochondrial adaptation in nonalcoholic fatty liver disease: novel mechanisms and treatment strategies
10.1016/j.tem.2016.11.006 · 2017 · External reference
Cardiolipin synthesis in brown and beige fat mitochondria is essential for systemic energy homeostasis
10.1016/j.cmet.2018.05.003 · 2018 · External reference
Mitochondria-targeted antioxidant mitoquinone attenuates liver inflammation and fibrosis in cirrhotic rats
10.1152/ajpgi.00135.2019 · 2020 · External reference
Non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, metabolic syndrome and hepatocellular carcinoma-a composite scenario
10.21037/hbsn.2018.01.01 · 2018 · External reference
Characterization of lymphoblast mitochondria from patients with Barth syndrome
10.1038/labinvest.3700274 · 2005 · External reference
Loss of protein association causes cardiolipin degradation in Barth syndrome
10.1038/nchembio.2113 · 2016 · External reference
Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes
10.1002/hep.28431 · 2016 · External reference
Inhibitory effect of silymarin on CCl4-induced liver fibrosis by reducing Ly6Chi monocytes infiltration
2017 · External reference
Defective phosphatidylglycerol remodeling causes hepatopathy, linking mitochondrial dysfunction to hepatosteatosis
10.1016/j.jcmgh.2019.02.002 · 2019 · External reference
Two roads diverge in the sick liver, monocytes travel both
10.1016/j.immuni.2020.08.006 · 2020 · External reference
Cardiolipin deficiency disrupts electron transport chain and drives steatohepatitis
10.17632/v3zhnw3b3t.1 · 2026 · External reference