Research graph
References from The insulin/IGF axis is critically important for controlling gene transcription in the podocyte. Local targets link to admitted publications; unresolved targets remain external evidence.
Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
10.1038/ng0196-106 · 1996 · External reference
A cell-autonomous signature of dysregulated protein phosphorylation underlies muscle insulin resistance in type 2 diabetes
10.1016/j.cmet.2020.08.007 · 2020 · External reference
Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
10.1210/er.2008-0047 · 2009 · External reference
Differential roles of insulin and IGF-1 receptors in adipose tissue development and function
10.2337/db16-0212 · 2016 · External reference
Loss of genome maintenance accelerates podocyte damage and aging
10.1101/2020.09.13.295303 · 2020 · External reference
Widespread intron retention in mammals functionally tunes transcriptomes
10.1101/gr.177790.114 · 2014 · External reference
Insulin-like growth factors inhibit podocyte apoptosis through the PI3 kinase pathway
10.1111/j.1523-1755.2005.00208.x · 2005 · External reference
The role of the type I insulin-like growth factor receptor (IGF-IR) in glomerular integrity
10.1016/j.ghir.2007.06.003 · 2008 · External reference
The augmented R-loop is a unifying mechanism for myelodysplastic syndromes induced by high-risk splicing factor mutations
10.1016/j.molcel.2017.12.029 · 2018 · External reference
The human glomerular podocyte is a novel target for insulin action
10.2337/diabetes.54.11.3095 · 2005 · External reference
Retained introns in long RNA-seq reads are not reliably detected in sample-matched short reads
10.1186/s13059-022-02789-6 · 2022 · External reference
Widespread intron retention diversifies most cancer transcriptomes
10.1186/s13073-015-0168-9 · 2015 · External reference
Gencode 2021
10.1093/nar/gkaa1087 · 2021 · External reference
Nuclear speckles: molecular organization, biological function and role in disease
10.1093/nar/gkx759 · 2017 · External reference
Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors
10.1186/s13041-015-0138-6 · 2015 · External reference
Spliceosomopathies: Diseases and mechanisms
10.1002/dvdy.214 · 2020 · External reference
Fibronectin containing alternatively spliced extra domain A interacts at the central and c-terminal domain of Toll-like receptor-4
10.1038/s41598-022-13622-2 · 2022 · External reference
Insulin-like growth factor-II is produced by, signals to and is an important survival factor for the mature podocyte in man and mouse
10.1002/path.4165 · 2013 · External reference
DNA damage repair and DNA methylation in the kidney
10.1159/000501356 · 2019 · External reference
Decreased KAT5 expression impairs DNA repair and induces altered DNA methylation in kidney podocytes
10.1016/j.celrep.2019.01.005 · 2019 · External reference
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
10.1038/nature01298 · 2003 · External reference
Podocyte GSK3 is an evolutionarily conserved critical regulator of kidney function
10.1038/s41467-018-08235-1 · 2019 · External reference
Contrasting consequences of podocyte insulin-like growth factor 1 receptor inhibition
10.1016/j.isci.2024.109749 · 2024 · External reference
Inhibition of insulin/IGF-1 receptor signaling protects from mitochondria-mediated kidney failure
10.15252/emmm.201404916 · 2015 · External reference
Apoptosis induction and cell cycle arrest of pladienolide B in erythroleukemia cell lines
10.1007/s10637-019-00796-2 · 2020 · External reference
Generating conditionally immortalised podocyte cell lines from wild-type mice
10.1159/000369816 · 2015 · External reference
Mitogenic and metabolic effects of type I IGF receptor overexpression in insulin receptor-deficient hepatocytes
10.1210/endo.142.8.8332 · 2001 · External reference
Titration of SF3B1 activity reveals distinct effects on the transcriptome and cell physiology
10.3390/ijms21249641 · 2020 · External reference
Construction of a viral T2A-peptide based knock-in mouse model for enhanced Cre recombinase activity and fluorescent labeling of podocytes
10.1016/j.kint.2016.12.011 · 2017 · External reference
Cellular fibronectins are differentially expressed in human fetal and adult kidney
1991 · External reference
RNA-seq analysis is easy as 1-2-3 with limma, Glimma and edgeR
10.12688/f1000research.9005.3 · 2016 · External reference
A role for NPY-NPY2R signaling in albuminuric kidney disease
10.1073/pnas.2004651117 · 2020 · External reference
Absence of renal enlargement in fructose-fed proximal-tubule-select insulin receptor (IR), insulin-like-growth factor receptor (IGF1R) double knockout mice
10.14814/phy2.13052 · 2016 · External reference
Neurodegenerative diseases: a hotbed for splicing defects and the potential therapies
10.1186/s40035-021-00240-7 · 2021 · External reference
Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy
10.1038/ncomms7496 · 2015 · External reference
TGFβ1-mediated expression and alternative splicing of Fibronectin Extra Domain A in human podocyte culture
10.14715/cmb/2018.64.3.4 · 2018 · External reference
Glomerulosclerosis and tubulointerstitial fibrosis are attenuated with 17beta-estradiol in the aging Dahl salt sensitive rat
10.1097/01.asn.0000128219.65330.ea · 2004 · External reference
A day in the life of the spliceosome
10.1038/nrm3742 · 2014 · External reference
IRFinder: assessing the impact of intron retention on mammalian gene expression
10.1186/s13059-017-1184-4 · 2017 · External reference
Regulation of the fibronectin EDA exon alternative splicing. Cooperative role of the exonic enhancer element and the 5’ splicing site
10.1016/s0014-5793(98)01201-0 · 1998 · External reference
Distinct and overlapping functions of insulin and IGF-I receptors
10.1210/edrv.22.6.0452 · 2001 · External reference
Insulin and IGF1 receptors are essential for the development and steroidogenic function of adult Leydig cells
10.1096/fj.201700769rr · 2018 · External reference
Differential role of insulin/IGF-1 receptor signaling in muscle growth and glucose homeostasis
10.1016/j.celrep.2015.04.037 · 2015 · External reference
The relationship between proteinuria and coronary risk: a systematic review and meta-analysis
10.1371/journal.pmed.0050207 · 2008 · External reference
A dynamic intron retention program enriched in RNA processing genes regulates gene expression during terminal erythropoiesis
10.1093/nar/gkv1168 · 2016 · External reference
Accurate isoform discovery with IsoQuant using long reads
10.1038/s41587-022-01565-y · 2023 · External reference
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
10.1093/bioinformatics/btp616 · 2010 · External reference
A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression
10.1681/asn.v133630 · 2002 · External reference
The RNA splicing response to DNA damage
10.3390/biom5042935 · 2015 · External reference
Insulin signaling in the hippocampus and amygdala regulates metabolism and neurobehavior
10.1073/pnas.1817391116 · 2019 · External reference
Potential effect of spliceosome inhibition in small cell lung cancer irrespective of the MYC status
10.1371/journal.pone.0172209 · 2017 · External reference
Splicing, genome stability and disease: splice like your genome depends on it!
10.1007/s00294-019-00964-0 · 2019 · External reference
Full-length transcript characterization of SF3B1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns
10.1038/s41467-020-15171-6 · 2020 · External reference
Chronic kidney disease and mortality risk: a systematic review
10.1681/asn.2005101085 · 2006 · External reference
Temporal phosphoproteomics reveals circuitry of phased propagation in insulin signaling
10.1038/s41467-025-56335-6 · 2025 · External reference
ProteomeXchange provides globally coordinated proteomics data submission and dissemination
10.1038/nbt.2839 · 2014 · External reference
Distribution of fibronectin isoforms in human renal disease
10.1002/1096-9896(2000)9999:9999<::aid-path783>3.0.co;2-p · 2001 · External reference
Insulin receptor compensates for IGF1R inhibition and directly induces mitogenic activity in prostate cancer cells
10.1530/ec-13-0086 · 2014 · External reference
Insulin signaling to the glomerular podocyte is critical for normal kidney function
10.1016/j.cmet.2010.08.015 · 2010 · External reference
Fibronectin splice variants: understanding their multiple roles in health and disease using engineered mouse models
10.1002/iub.493 · 2011 · External reference
Emerging roles of spliceosome in cancer and immunity
10.1007/s13238-021-00856-5 · 2022 · External reference
Biological validation that SF3b is a target of the antitumor macrolide pladienolide
10.1111/j.1742-4658.2011.08387.x · 2011 · External reference
Significance of podocyte DNA damage and glomerular DNA methylation in CKD patients with proteinuria
10.1038/s41440-023-01169-2 · 2023 · External reference
Inhibition of SF3b1 by pladienolide B evokes cycle arrest, apoptosis induction and p73 splicing in human cervical carcinoma cells
10.1080/21691401.2019.1596922 · 2019 · External reference
Inhibition of splicing factor 3b subunit 1 (SF3B1) reduced cell proliferation, induced apoptosis and resulted in cell cycle arrest by regulating homeobox a10 (hoxa10) splicing in ags and mkn28 human gastric cancer cells
10.12659/msm.919460 · 2020 · External reference
Phosphorylation-dependent charge blocks regulate the relaxation of nuclear speckle networks
10.1016/j.molcel.2025.03.016 · 2025 · External reference
Insulin and IGF1 receptor function in murine podocytes
2024 · External reference
Long-read (ONT) RNA-seq of Insr/Igf1r double-knockout and wild-type mouse podocytes
2026 · External reference
