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References from Sex-biased expression of enteroendocrine cell-derived hormones contributes to higher fat storage in Drosophila females. Local targets link to admitted publications; unresolved targets remain external evidence.
RNA-seq analysis of Drosophila clock and non-clock neurons reveals neuron-specific cycling and novel candidate neuropeptides
10.1371/journal.pgen.1006613 · 2017 · External reference
Fitness trade-offs incurred by ovary-to-gut steroid signalling in Drosophila
10.1038/s41586-020-2462-y · 2020 · External reference
Enteroendocrine cells support intestinal stem-cell-mediated homeostasis in Drosophila
10.1016/j.celrep.2014.08.052 · 2014 · External reference
Early manipulation of juvenile hormone has sexually dimorphic effects on mature adult behavior in Drosophila melanogaster
10.1016/j.yhbeh.2013.08.018 · 2013 · External reference
Insect fat body: energy, metabolism, and regulation
10.1146/annurev-ento-112408-085356 · 2010 · External reference
Tachykinin-expressing neurons control male-specific aggressive arousal in Drosophila
10.1016/j.cell.2013.11.045 · 2014 · External reference
Sex differences in Drosophila behavior: qualitative and quantitative dimorphism
10.1016/j.cophys.2018.04.004 · 2018 · External reference
Neuro-hormonal control of sexual behavior in insects
10.1146/annurev.en.18.010173.002305 · 1973 · External reference
Sexual dimorphisms in innate immunity and responses to infection in Drosophila melanogaster
10.3389/fimmu.2019.03075 · 2019 · External reference
A leptin analog locally produced in the brain acts via a conserved neural circuit to modulate obesity-linked behaviors in Drosophila
10.1016/j.cmet.2016.12.013 · 2017 · External reference
Regulation of onset of female mating and sex pheromone production by juvenile hormone in Drosophila melanogaster
10.1073/pnas.1318119110 · 2013 · External reference
Control of male sexual behavior in Drosophila by the sex determination pathway
10.1016/j.cub.2006.08.025 · 2006 · External reference
Regulation of insulin-producing cells in the adult Drosophila brain via the tachykinin peptide receptor DTKR
10.1242/jeb.062091 · 2011 · External reference
Insulin/insulin-like growth factor signaling pathway promotes higher fat storage in Drosophila females
10.1016/j.celrep.2025.115915 · 2025 · External reference
The sex of organ geometry
10.1038/s41586-024-07463-4 · 2024 · External reference
Ecdysteroids in adult males and females of Drosophila melanogaster
10.1016/0022-1910(84)90019-2 · 1984 · External reference
All for one and one for all: Regionalization of the Drosophila intestine
10.1016/j.ibmb.2015.05.015 · 2015 · External reference
Mutations in the midway gene disrupt a Drosophila acyl coenzyme A: diacylglycerol acyltransferase
10.1093/genetics/160.4.1511 · 2002 · External reference
Sexual dimorphism in the fly brain
10.1016/j.cub.2010.07.045 · 2010 · External reference
The creation of sexual dimorphism in the Drosophila soma
10.1016/s0070-2153(08)00403-1 · 2008 · External reference
An important role for triglyceride in regulating spermatogenesis
10.1101/2022.12.16.520841 · 2024 · External reference
A systematic analysis of drosophila regulatory peptide expression in enteroendocrine cells
10.14348/molcells.2016.0014 · 2016 · External reference
Nutrient sensing via gut in Drosophila melanogaster
10.3390/ijms23052694 · 2022 · External reference
Drosophila neuropeptide F signaling independently regulates feeding and sleep-wake behavior
10.1016/j.celrep.2017.05.085 · 2017 · External reference
Enteric neurons and systemic signals couple nutritional and reproductive status with intestinal homeostasis
10.1016/j.cmet.2010.12.010 · 2011 · External reference
Ecdysone receptor acts in fruitless- expressing neurons to mediate drosophila courtship behaviors
10.1016/j.cub.2009.06.063 · 2009 · External reference
Sexual dimorphism in metabolic responses to western diet in Drosophila melanogaster
10.3390/biom12010033 · 2021 · External reference
Allatostatin-C/AstC-R2 is a novel pathway to modulate the circadian activity pattern in Drosophila
10.1016/j.cub.2018.11.005 · 2019 · External reference
Specification of regional intestinal stem cell identity during Drosophila metamorphosis
10.1242/dev.104018 · 2014 · External reference
The Toll pathway underlies host sexual dimorphism in resistance to both Gram-negative and Gram-positive bacteria in mated Drosophila
10.1186/s12915-017-0466-3 · 2017 · External reference
Drosophila switch gene Sex-lethal can bypass its switch-gene target transformer to regulate aspects of female behavior
10.1073/pnas.1319063110 · 2013 · External reference
Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history
10.1002/bies.20290 · 2005 · External reference
Coordination of insulin and Notch pathway activities by microRNA miR-305 mediates adaptive homeostasis in the intestinal stem cells of the Drosophila gut
10.1101/gad.241588.114 · 2014 · External reference
Drosophila female-specific Ilp7 motoneurons are generated by Fruitless-dependent cell death in males and by a double-assurance survival role for Transformer in females
10.1242/dev.150821 · 2018 · External reference
Hox gene Abdominal-B uses DoublesexF as a cofactor to promote neuroblast apoptosis in Drosophila central nervous system
10.1242/dev.175158 · 2019 · External reference
The specification and function of enteroendocrine cells in Drosophila and mammals: a comparative review
10.1111/febs.16067 · 2022 · External reference
Specialized hepatocyte-like cells regulate Drosophila lipid metabolism
10.1038/nature05382 · 2007 · External reference
Enteric neurons increase maternal food intake during reproduction
10.1038/s41586-020-2866-8 · 2020 · External reference
Ecdysteroid titers in mated and unmated Drosophila melanogaster females
10.1016/s0022-1910(99)00038-4 · 1999 · External reference
Regulation of sex-specific selection of fruitless 5’ splice sites by transformer and transformer-2
10.1128/mcb.18.1.450 · 1998 · External reference
The neuropeptide allatostatin a regulates metabolism and feeding decisions in Drosophila
10.1038/srep11680 · 2015 · External reference
Cellular sex throughout the organism underlies somatic sexual differentiation
10.1038/s41467-024-51228-6 · 2024 · External reference
Allatostatin-A neurons inhibit feeding behavior in adult Drosophila
10.1073/pnas.1200778109 · 2012 · External reference
The sexual identity of adult intestinal stem cells controls organ size and plasticity
10.1038/nature16953 · 2016 · External reference
A cell atlas of the adult Drosophila midgut
10.1073/pnas.1916820117 · 2020 · External reference
Intestinal stem cells in the adult Drosophila midgut
10.1016/j.yexcr.2011.07.020 · 2011 · External reference
Intact Drosophila central nervous system cellular quantitation reveals sexual dimorphism
10.7554/elife.74968 · 2022 · External reference
The Drosophila immune deficiency pathway modulates enteroendocrine function and host metabolism
10.1016/j.cmet.2018.05.026 · 2018 · External reference
Identified peptidergic neurons in the Drosophila brain regulate insulin-producing cells, stress responses and metabolism by coexpressed short neuropeptide F and corazonin
10.1007/s00018-012-1097-z · 2012 · External reference
Fruitless specifies sexually dimorphic neural circuitry in the Drosophila brain
10.1038/nature04229 · 2005 · External reference
Fruitless and doublesex coordinate to generate male-specific neurons that can initiate courtship
10.1016/j.neuron.2008.06.007 · 2008 · External reference
Role of cell death in the formation of sexual dimorphism in the Drosophila central nervous system
10.1111/j.1440-169x.2010.01223.x · 2011 · External reference
Specialized cortex glial cells accumulate lipid droplets in Drosophila melanogaster
10.1371/journal.pone.0131250 · 2015 · External reference
Functional annotation of two orphan G-protein-coupled receptors, Drostar1 and -2, from Drosophila melanogaster and their ligands by reverse pharmacology
10.1074/jbc.m206931200 · 2002 · External reference
Systemic corazonin signalling modulates stress responses and metabolism in Drosophila
10.1098/rsob.160152 · 2016 · External reference
The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress
10.1038/s41467-022-28268-x · 2022 · External reference
LGR signaling mediates muscle-adipose tissue crosstalk and protects against diet-induced insulin resistance
10.1038/s41467-024-50468-w · 2024 · External reference
Gut hormone signaling drives sex differences in metabolism and behavior
10.1016/j.molmet.2025.102312 · 2026 · External reference
The contribution of the Drosophila model to lipid droplet research
10.1016/j.plipres.2011.04.001 · 2011 · External reference
Thematic review series: Lipid droplet synthesis and metabolism: from yeast to man. Lipid droplet-based storage fat metabolism in Drosophila
10.1194/jlr.r024299 · 2012 · External reference
Calcitonin gene-related peptide neurons mediate sleep-specific circadian output in Drosophila
10.1016/j.cub.2014.09.077 · 2014 · External reference
Female reproductive dormancy in Drosophila is regulated by DH31-producing neurons projecting into the corpus allatum
10.1242/dev.201186 · 2023 · External reference
Lipid content of terrestrial arthropods in relation to body size, phylogeny, ontogeny and sex
10.1111/j.1365-3032.2010.00767.x · 2011 · External reference
Sex- and clock-controlled expression of the neuropeptide F gene in Drosophila
10.1073/pnas.0601171103 · 2006 · External reference
Metabolic control of daily locomotor activity mediated by tachykinin in Drosophila
10.1038/s42003-021-02219-6 · 2021 · External reference
The digestive tract of Drosophila melanogaster
10.1146/annurev-genet-111212-133343 · 2013 · External reference
Steroid signaling promotes stem cell maintenance in the Drosophila testis
10.1016/j.ydbio.2014.07.016 · 2014 · External reference
Mating modifies oxidative stress in the brain and confers protection against Parkinson’s Disease in a Drosophila model
10.1016/j.bbrc.2024.150911 · 2024 · External reference
Functional dissection of a neuronal network required for cuticle tanning and wing expansion in Drosophila
10.1523/jneurosci.3916-05.2006 · 2006 · External reference
A gut-derived hormone suppresses sugar appetite and regulates food choice in Drosophila
10.1038/s42255-022-00672-z · 2022 · External reference
Adipocyte metabolic pathways regulated by diet control the female germline stem cell lineage in Drosophila melanogaster
10.1534/genetics.117.201921 · 2017 · External reference
Ectopic expression of the female transformer gene product leads to female differentiation of chromosomally male Drosophila
10.1016/s0092-8674(88)90369-8 · 1988 · External reference
Drosophila molting neurohormone bursicon is a heterodimer and the natural agonist of the orphan receptor DLGR2
10.1016/j.febslet.2005.03.006 · 2005 · External reference
Evidence that stem cells reside in the adult Drosophila midgut epithelium
10.1038/nature04371 · 2006 · External reference
Anatomy and physiology of the digestive tract of Drosophila melanogaster
10.1534/genetics.118.300224 · 2018 · External reference
A large population of diverse neurons in the Drosophila central nervous system expresses short neuropeptide F, suggesting multiple distributed peptide functions
10.1186/1471-2202-9-90 · 2008 · External reference
Insulin/IGF signaling in Drosophila and other insects: factors that regulate production, release and post-release action of the insulin-like peptides
10.1007/s00018-015-2063-3 · 2016 · External reference
Recent advances in neuropeptide signaling in Drosophila, from genes to physiology and behavior
10.1016/j.pneurobio.2019.02.003 · 2019 · External reference
Neuronal synaptic outputs determine the sexual fate of postsynaptic targets
10.1016/j.cub.2010.02.064 · 2010 · External reference
A sex-specific switch between visual and olfactory inputs underlies adaptive sex differences in behavior
10.1016/j.cub.2020.12.047 · 2021 · External reference
Altered modes of stem cell division drive adaptive intestinal growth
10.1016/j.cell.2011.08.048 · 2011 · External reference
A glucose-sensing neuron pair regulates insulin and glucagon in Drosophila
10.1038/s41586-019-1675-4 · 2019 · External reference
The adult Drosophila posterior midgut is maintained by pluripotent stem cells
10.1038/nature04333 · 2006 · External reference
Genetic control of germline sexual dimorphism in Drosophila
10.1016/s0074-7696(02)19010-3 · 2002 · External reference
FlyBase: updates to the Drosophila genes and genomes database
10.1093/genetics/iyad211 · 2024 · External reference
Lipoproteins in Drosophila melanogaster--assembly, function, and influence on tissue lipid composition
10.1371/journal.pgen.1002828 · 2012 · External reference
Lipid profiles of female and male Drosophila
10.1186/1756-0500-4-198 · 2011 · External reference
Sexual dimorphism in the immune response of Drosophila melanogaster to the entomopathogenic fungus Metarhizium anisopliae
10.1016/j.jip.2025.108422 · 2025 · External reference
Characterization and distribution of NKD, a receptor for Drosophila tachykinin-related peptide 6
10.1016/j.peptides.2008.10.012 · 2009 · External reference
A novel satiety sensor detects circulating glucose and suppresses food consumption via insulin-producing cells in Drosophila
10.1038/s41422-020-00449-7 · 2021 · External reference
Local Juvenile Hormone activity regulates gut homeostasis and tumor growth in adult Drosophila
10.1038/s41598-017-11199-9 · 2017 · External reference
3.9 - hormonal control of reproductive processes
10.1016/b0-44-451924-6/00040-5 · 2005 · External reference
Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction
10.7554/elife.10956 · 2016 · External reference
Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin
10.1038/s43587-022-00308-7 · 2022 · External reference
Endocrine remodelling of the adult intestine sustains reproduction in Drosophila
10.7554/elife.06930 · 2015 · External reference
Peptidomics and peptide hormone processing in the Drosophila midgut
10.1021/pr101116g · 2011 · External reference
CCHamide-2 is an orexigenic brain-gut peptide in Drosophila
10.1371/journal.pone.0133017 · 2015 · External reference
Cell class-lineage analysis reveals sexually dimorphic lineage compositions in the Drosophila brain
10.1016/j.cub.2016.07.086 · 2016 · External reference
Ecdysone receptors and their biological actions
10.1016/s0083-6729(00)60016-x · 2000 · External reference
The sex determination gene transformer regulates male-female differences in Drosophila body size
10.1371/journal.pgen.1005683 · 2015 · External reference
Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene
10.1016/s0092-8674(00)81802-4 · 1996 · External reference
Doublesex establishes sexual dimorphism in the Drosophila central nervous system in an isoform-dependent manner by directing cell number
10.1016/j.ydbio.2008.05.543 · 2008 · External reference
The nutrient-responsive hormone CCHamide-2 controls growth by regulating insulin-like peptides in the brain of Drosophila melanogaster
10.1371/journal.pgen.1005209 · 2015 · External reference
Molecular and cellular origins of behavioral sex differences: a tiny little fly tells a lot
10.3389/fnmol.2023.1284367 · 2023 · External reference
Minireview: Development and differentiation of gut endocrine cells
10.1210/en.2004-0051 · 2004 · External reference
Evolution of starvation resistance in Drosophila melanogaster: measurement of direct and correlated responses to artificial selection
10.1111/j.1420-9101.2011.02428.x · 2012 · External reference
Ecdysone signaling in adult Drosophila melanogaster
10.1016/j.jinsphys.2012.01.013 · 2012 · External reference
Local control of intestinal stem cell homeostasis by enteroendocrine cells in the adult Drosophila midgut
10.1016/j.cub.2014.04.007 · 2014 · External reference
A neuronal relay mediates a nutrient responsive Gut/Fat body axis regulating energy homeostasis in Adult Drosophila
10.1016/j.cmet.2018.09.021 · 2019 · External reference
Sexual dimorphism in Drosophila melanogaster survival of Beauveria bassiana infection depends on core immune signaling
10.1038/s41598-018-30527-1 · 2018 · External reference
The DHR96 nuclear receptor controls triacylglycerol homeostasis in Drosophila
10.1016/j.cmet.2009.10.010 · 2009 · External reference
Steroid signaling establishes a female metabolic state and regulates SREBP to control oocyte lipid accumulation
10.1016/j.cub.2015.02.019 · 2015 · External reference
Control of lipid metabolism by tachykinin in Drosophila
10.1016/j.celrep.2014.08.060 · 2014 · External reference
Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophila and mouse
10.1038/s41422-023-00800-8 · 2023 · External reference
A gene in Drosophila melanogaster that transforms females into males
10.1093/genetics/30.3.297 · 1945 · External reference
Commitment of abdominal neuroblasts in Drosophila to a male or female fate is dependent on genes of the sex-determining hierarchy
10.1242/dev.114.3.625 · 1992 · External reference
The role of peptide hormones in insect lipid metabolism
10.3389/fphys.2020.00434 · 2020 · External reference
Spatial and temporal patterns of neurogenesis in the central nervous system of Drosophila melanogaster
10.1016/0012-1606(88)90067-x · 1988 · External reference
Regulatory peptides in fruit fly midgut
10.1007/s00441-008-0708-3 · 2008 · External reference
Peptidergic paracrine and endocrine cells in the midgut of the fruit fly maggot
10.1007/s00441-009-0769-y · 2009 · External reference
Time-restricted feeding restores muscle function in Drosophila models of obesity and circadian-rhythm disruption
10.1038/s41467-019-10563-9 · 2019 · External reference
A role for triglyceride lipase brummer in the regulation of sex differences in Drosophila fat storage and breakdown
10.1371/journal.pbio.3000595 · 2020 · External reference
Sex determination gene transformer regulates the male-female difference in Drosophila fat storage via the adipokinetic hormone pathway
10.7554/elife.72350 · 2021 · External reference
Chemical identity, function and regulation of enteroendocrine peptides in insects
10.1016/j.cois.2015.07.003 · 2015 · External reference
Drosophila melanogaster sex peptide regulates mated female midgut morphology and physiology
10.1073/pnas.2018112118 · 2021 · External reference
Juvenile hormone is required in adult males for Drosophila courtship
10.1371/journal.pone.0151912 · 2016 · External reference
Tachykinin-related peptides modulate odor perception and locomotor activity in Drosophila
10.1016/j.mcn.2005.10.010 · 2006 · External reference
The aligned rank transform for nonparametric factorial analyses using only ANOVA procedures
10.1145/1978942.1978963 · 2011 · External reference
Cellular and molecular actions of juvenile hormone. II. roles of juvenile hormone in adult insects
10.1016/s0065-2806(08)60030-2 · 1996 · External reference
The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster
10.1038/s41467-021-25146-w · 2021 · External reference
Modulation of Drosophila post-feeding physiology and behavior by the neuropeptide leucokinin
10.1371/journal.pgen.1007767 · 2018 · External reference
Ecdysone signaling regulates specification of neurons with a male-specific neurite in Drosophila
10.1242/bio.029744 · 2018 · External reference
The neuropeptide allatostatin C from clock-associated DN1p neurons generates the circadian rhythm for oogenesis
10.1073/pnas.2016878118 · 2021 · External reference
Physiological and pathological regulation of peripheral metabolism by gut-peptide hormones in Drosophila
10.3389/fphys.2020.577717 · 2020 · External reference
Ecdysone steroid hormone remote controls intestinal stem cell fate decisions via the PPARγ-homolog Eip75B in Drosophila
10.7554/elife.55795 · 2020 · External reference
