Research graph
References from Human CD1c-autoreactive T-cells recognise Mycobacterium tuberculosis-infected antigen-presenting cells and display cytotoxic effector programmes. Local targets link to admitted publications; unresolved targets remain external evidence.
Exogenous control of the expression of Group I CD1 molecules competent for presentation of microbial nonpeptide antigens to human T lymphocytes
10.1155/2011/790460 · 2011 · External reference
A bioengineered three-dimensional cell culture platform integrated with microfluidics to address antimicrobial resistance in tuberculosis
10.1128/mbio.02073-16 · 2017 · External reference
Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals
10.1038/ni.2143 · 2011 · External reference
Co-evolution of Mycobacterium tuberculosis and Homo sapiens
10.1111/imr.12264 · 2015 · External reference
The versatility of the CD1 lipid antigen presentation pathway
10.1111/imm.12912 · 2018 · External reference
Out-of-Africa migration and Neolithic coexpansion of Mycobacterium tuberculosis with modern humans
10.1038/ng.2744 · 2013 · External reference
Lipids hide or step aside for CD1-autoreactive T cell receptors
10.1016/j.coi.2018.04.013 · 2018 · External reference
CD1c presentation of synthetic glycolipid antigens with foreign Alkyl Branching Motifs
10.1016/j.chembiol.2007.09.010 · 2007 · External reference
CD1a-autoreactive T cells are a normal component of the human αβ T cell repertoire
10.1038/ni.1956 · 2010 · External reference
High-frequency and adaptive-like dynamics of human CD1 self-reactive T cells
10.1002/eji.201041211 · 2011 · External reference
CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice
10.1084/jem.20090898 · 2009 · External reference
Signatures of environmental genetic adaptation pinpoint pathogens as the main selective pressure through human evolution
10.1371/journal.pgen.1002355 · 2011 · External reference
Bacillus Calmette-Guérin shares with virulent Mycobacterium tuberculosis the capacity to subvert monocyte differentiation into dendritic cell: implication for its efficacy as a vaccine preventing tuberculosis
10.1016/j.vaccine.2004.07.009 · 2004 · External reference
CD36 family members are TCR-independent ligands for CD1 antigen-presenting molecules
10.1126/sciimmunol.abg4176 · 2021 · External reference
A novel cell-based luciferase reporter platform for the development and characterization of T-cell redirecting therapies and vaccine development
10.1097/cji.0000000000000453 · 2023 · External reference
A subset of human autoreactive CD1c-Restricted T cells preferentially expresses TRBV4-1+ TCRs
10.4049/jimmunol.1700677 · 2018 · External reference
CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms
10.1016/j.cell.2023.08.022 · 2023 · External reference
Global tuberculosis response off track: urgent priorities to end the world’s top infectious killer
10.1016/s0140-6736(25)02433-x · 2026 · External reference
T cells and adaptive immunity to Mycobacterium tuberculosis in humans
10.1111/imr.12274 · 2015 · External reference
Harnessing donor unrestricted T-cells for new vaccines against tuberculosis
10.1016/j.vaccine.2019.04.050 · 2019 · External reference
Natural selection and infectious disease in human populations
10.1038/nrg3734 · 2014 · External reference
A novel self-lipid antigen targets human T cells against CD1c(+) leukemias
10.1084/jem.20140410 · 2014 · External reference
Autoreactive CD1b-restricted T cells: a new innate-like T-cell population that contributes to immunity against infection
10.1182/blood-2011-03-341941 · 2011 · External reference
CD1c tetramers detect ex vivo T cell responses to processed phosphomycoketide antigens
10.1084/jem.20120624 · 2013 · External reference
Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells
10.1073/pnas.1519246113 · 2016 · External reference
Mycobacterium tuberculosis pks12 produces a novel polyketide presented by CD1c to T cells
10.1084/jem.20041429 · 2004 · External reference
CD1 expression in human atherosclerosis. A potential mechanism for T cell activation by foam cells
10.1016/s0002-9440(10)65176-0 · 1999 · External reference
CD1c-mediated T-cell recognition of isoprenoid glycolipids in Mycobacterium tuberculosis infection
10.1038/35009119 · 2000 · External reference
The immunology of CD1- and MR1-restricted T cells
10.1146/annurev-immunol-032414-112008 · 2016 · External reference
Safety, immunogenicity, and efficacy of the candidate tuberculosis vaccine MVA85A in healthy adults infected with HIV-1: a randomised, placebo-controlled, phase 2 trial
10.1016/s2213-2600(15)00037-5 · 2015 · External reference
Duration of BCG protection against tuberculosis and change in effectiveness with time since vaccination in Norway: a retrospective population-based cohort study
10.1016/s1473-3099(15)00400-4 · 2016 · External reference
In search of a new paradigm for protective immunity to TB
10.1038/nrmicro3230 · 2014 · External reference
The immune response in tuberculosis
10.1146/annurev-immunol-032712-095939 · 2013 · External reference
Gene activation precedes DNA demethylation in response to infection in human dendritic cells
10.1073/pnas.1814700116 · 2019 · External reference
Epidemiology: A mortal foe
10.1038/502s2a · 2013 · External reference
Full-length RNA-seq from single cells using Smart-seq2
10.1038/nprot.2014.006 · 2014 · External reference
A co-evolutionary perspective on humans and Mycobacterium tuberculosis in the era of systems biology
10.7554/elife.108175 · 2026 · External reference
CD1b presents self and Borrelia burgdorferi diacylglycerols to human T cells
10.1002/eji.201847949 · 2019 · External reference
Cytokine interactions that determine the outcome of Mycobacterial infection of macrophages
10.1016/j.cyto.2010.04.005 · 2010 · External reference
CD1a and CD1c activate intrathyroidal T cells during Graves’ disease and Hashimoto’s thyroiditis
10.4049/jimmunol.174.6.3773 · 2005 · External reference
Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by αβ T cells
10.1073/pnas.1408549111 · 2014 · External reference
Molecular analysis of lipid-reactive Vδ1 γδ T cells identified by CD1c tetramers
10.4049/jimmunol.1502202 · 2016 · External reference
The role of donor-unrestricted T-cells, innate lymphoid cells, and NK cells in anti-mycobacterial immunity
10.1111/imr.12948 · 2021 · External reference
The 2.5 Å structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation
10.1016/j.immuni.2010.11.026 · 2010 · External reference
The status of tuberculosis vaccine development
10.1016/s1473-3099(19)30625-5 · 2020 · External reference
Human double-negative T cells in systemic lupus erythematosus provide help for IgG and are restricted by CD1c
10.4049/jimmunol.165.9.5338 · 2000 · External reference
Self-recognition of CD1 by gamma/delta T cells: implications for innate immunity
10.1084/jem.191.6.937 · 2000 · External reference
An antimicrobial activity of cytolytic T cells mediated by granulysin
10.1126/science.282.5386.121 · 1998 · External reference
Down-regulation of CD1 on antigen-presenting cells by infection with Mycobacterium tuberculosis
10.4049/jimmunol.161.7.3582 · 1998 · External reference
Codiversification of gut microbiota with humans
10.1126/science.abm7759 · 2022 · External reference
Final analysis of a trial of M72/AS01E vaccine to prevent tuberculosis
10.1056/nejmoa1909953 · 2019 · External reference
Safety and efficacy of MVA85A, a new tuberculosis vaccine, in infants previously vaccinated with BCG: a randomised, placebo-controlled phase 2b trial
10.1016/s0140-6736(13)60177-4 · 2013 · External reference
Human autoreactive T cells recognize CD1b and phospholipids
10.1073/pnas.1520947112 · 2016 · External reference
CD1a-, b-, and c-restricted TCRs recognize both self and foreign antigens
10.4049/jimmunol.175.10.6344 · 2005 · External reference
Tuberculosis--advances in development of new drugs, treatment regimens, host-directed therapies, and biomarkers
10.1016/s1473-3099(16)00070-0 · 2016 · External reference
MiR-381-3p regulates the antigen-presenting capability of dendritic cells and represses antituberculosis cellular immune responses by targeting CD1c
10.4049/jimmunol.1500481 · 2016 · External reference
Unresolved reference
2021 · External reference
T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids
10.1038/s41590-018-0065-7 · 2018 · External reference
Mycolic acid-specific T cells protect against Mycobacterium tuberculosis infection in a humanized transgenic mouse model
10.7554/elife.08525 · 2015 · External reference
Gene activation precedes DNA demethylation in response to infection in human dendritic cells
2026 · External reference
sc-RNAseq on CD1c restricted T-cells
2025 · External reference
