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References from SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid accumulation in liver-derived cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Non-alcoholic fatty liver disease: The diagnosis and management
10.4254/wjh.v7.i6.846 · 2015 · External reference
TWIST1 methylation by SETD6 selectively antagonizes LINC-PINT expression in glioma
10.1093/nar/gkac485 · 2022 · External reference
Mechanism of rapid transcriptional induction of tumor necrosis factor alpha-responsive genes by NF-kappaB
10.1128/mcb.22.18.6354-6362.2002 · 2002 · External reference
Histone methyltransferases in cancer
10.1016/j.semcdb.2009.10.007 · 2010 · External reference
An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ
10.1038/nature13887 · 2015 · External reference
SETD6 mediates selective interaction and genomic occupancy of BRD4 and MITF in melanoma cells
10.1093/narcan/zcaf023 · 2025 · External reference
Functional regulation of PPARs through post-translational modifications
10.3390/ijms19061738 · 2018 · External reference
Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA
10.1038/nature07413 · 2008 · External reference
Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling
10.1093/nar/gkr256 · 2011 · External reference
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
10.1186/1471-2105-14-128 · 2013 · External reference
Novel phosphorylation of PPARγ ameliorates obesity-induced adipose tissue inflammation and improves insulin sensitivity
10.1016/j.cellsig.2015.09.009 · 2015 · External reference
Orchestrating epigenetics: a comprehensive review of the methyltransferase SETD6
10.1038/s12276-025-01423-2 · 2025 · External reference
The role of peroxisome proliferator-activated receptors (PPAR) in immune responses
10.1016/j.metabol.2020.154338 · 2021 · External reference
Ligand binding reduces SUMOylation of the peroxisome proliferator-activated receptor γ (PPARγ) activation function 1 (AF1) domain
10.1371/journal.pone.0066947 · 2013 · External reference
PPARs and the complex journey to obesity
10.1038/nm1025 · 2004 · External reference
MultiQC: summarize analysis results for multiple tools and samples in a single report
10.1093/bioinformatics/btw354 · 2016 · External reference
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma
10.1016/0092-8674(95)90193-0 · 1995 · External reference
JASPAR 2020: update of the open-access database of transcription factor binding profiles
10.1093/nar/gkz1001 · 2020 · External reference
Peroxisome proliferator-activated receptors and their novel ligands as candidates for the treatment of non-alcoholic fatty liver disease
10.3390/cells9071638 · 2020 · External reference
Breaking a dogma: high-throughput live-cell imaging in real-time with hoechst 33342
10.1002/adhm.202300230 · 2023 · External reference
Natural history of nonalcoholic fatty liver disease
10.1007/s10620-016-4095-4 · 2016 · External reference
Perilipins: a diversity of intracellular lipid droplet proteins
10.1186/s12944-017-0473-y · 2017 · External reference
SetD7 (Set7/9) is a novel target of PPARγ that promotes the adaptive pancreatic β-cell glycemic response
10.1016/j.jbc.2021.101250 · 2021 · External reference
Methylation of the transcription factor E2F1 by SETD6 regulates SETD6 expression via a positive feedback mechanism
10.1016/j.jbc.2023.105236 · 2023 · External reference
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
10.1093/nar/gkw377 · 2016 · External reference
Pivotal roles of peroxisome proliferator-activated receptors (PPARs) and their signal cascade for cellular and whole-body energy homeostasis
10.3390/ijms19040949 · 2018 · External reference
Hepatic lipid homeostasis by peroxisome proliferator-activated receptor gamma 2
10.1016/j.livres.2018.12.001 · 2018 · External reference
The sva package for removing batch effects and other unwanted variation in high-throughput experiments
10.1093/bioinformatics/bts034 · 2012 · External reference
RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
10.1186/1471-2105-12-323 · 2011 · External reference
PDV: an integrative proteomics data viewer
10.1093/bioinformatics/bty770 · 2019 · External reference
PPARγ phase separates with RXRα at PPREs to regulate target gene expression
10.1038/s41421-022-00388-0 · 2022 · External reference
SMYD2-methylated pparγ facilitates hypoxia-induced pulmonary hypertension by activating mitophagy
10.1161/circresaha.124.323698 · 2024 · External reference
Mechanisms and disease consequences of nonalcoholic fatty liver disease
10.1016/j.cell.2021.04.015 · 2021 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Exploring PPAR gamma and PPAR alpha’s regulation role in metabolism via epigenetics mechanism
10.3390/biom14111445 · 2024 · External reference
Roles of Peroxisome Proliferator-Activated Receptor β/δ in skeletal muscle physiology
10.1016/j.biochi.2016.11.010 · 2017 · External reference
SETD6 dominant negative mutation in familial colorectal cancer type X
10.1093/hmg/ddx336 · 2017 · External reference
Cross-talk between lysine-modifying enzymes controls site-specific DNA amplifications
10.1016/j.cell.2018.06.018 · 2018 · External reference
PPARγ activates ABCA1 gene transcription but reduces the level of ABCA1 protein in HepG2 cells
10.1016/j.bbrc.2010.10.053 · 2010 · External reference
Lipid droplets in health and disease
10.1186/s12944-017-0521-7 · 2017 · External reference
A new perspective on NAFLD: Focusing on lipid droplets
10.1016/j.jhep.2021.11.009 · 2022 · External reference
Dynamic regulation of histone lysine methylation by demethylases
10.1016/j.molcel.2006.12.010 · 2007 · External reference
Lipid droplets and their component triglycerides and steryl esters regulate autophagosome biogenesis
10.15252/embj.201490315 · 2015 · External reference
Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice
10.1074/jbc.m114.595850 · 2014 · External reference
Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms
10.1186/1478-1336-3-3 · 2005 · External reference
The constitutive lipid droplet protein PLIN2 regulates autophagy in liver
10.1080/15548627.2017.1319544 · 2017 · External reference
E2F1 K117 methylation by SETD6 disrupts BRD4-E2F1 binding and modulates E2F1 chromatin binding and gene regulation in prostate cancer cells
10.1093/nar/gkaf1513 · 2026 · External reference
BRD4 methylation by the methyltransferase SETD6 regulates selective transcription to control mRNA translation
10.1126/sciadv.abf5374 · 2021 · External reference
PPARs: diverse regulators in energy metabolism and metabolic diseases
10.1038/cr.2010.13 · 2010 · External reference
PPARs as metabolic regulators in the liver: lessons from liver-specific PPAR-null mice
10.3390/ijms21062061 · 2020 · External reference
Peroxisome proliferator-activated receptors as therapeutic target for cancer
10.1111/jcmm.17931 · 2024 · External reference
Oligomerization and auto-methylation of the human lysine methyltransferase SETD6
10.1016/j.jmb.2018.08.028 · 2018 · External reference
Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States
10.1053/j.gastro.2014.11.039 · 2015 · External reference
Blockage of PPARγ T166 phosphorylation enhances the inducibility of beige adipocytes and improves metabolic dysfunctions
10.1038/s41418-022-01077-x · 2023 · External reference
Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase
10.1073/pnas.132274899 · 2002 · External reference
The role of peroxisome proliferator-activated receptor gamma and atherosclerosis: post-translational modification and selective modulators
10.3389/fphys.2022.826811 · 2022 · External reference
Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes
10.1002/hep.28431 · 2016 · External reference
Monoacylglycerol O-acyltransferase 1 is regulated by peroxisome proliferator-activated receptor γ in human hepatocytes and increases lipid accumulation
10.1016/j.bbrc.2015.03.095 · 2015 · External reference
Recent advances in fluorescent probes for lipid droplets
10.1039/d1cc05717k · 2022 · External reference
Cistrome Data Browser: expanded datasets and new tools for gene regulatory analysis
10.1093/nar/gky1094 · 2019 · External reference
Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis
10.2353/ajpath.2010.091010 · 2010 · External reference
SETD6-mediated methylation of PPARγ establishes a transcriptional feedback circuit promoting lipid accumulation in liver-derived cells
2026 · External reference