Research graph
References from Comprehensive lipidomics of tissue macrophages reveal LTE4–driven eosinophil survival. Local targets link to admitted publications; unresolved targets remain external evidence.
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis
10.1016/j.immuni.2012.12.001 · 2013 · External reference
Tissue-Resident Macrophage Ontogeny and Homeostasis
10.1016/j.immuni.2016.02.024 · 2016 · External reference
Establishment and Maintenance of the Macrophage Niche
10.1016/j.immuni.2020.02.015 · 2020 · External reference
Tissue-resident macrophages
10.1038/ni.2705 · 2013 · External reference
Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival
10.1084/jem.20140570 · 2014 · External reference
The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal
10.1126/science.1251414 · 2014 · External reference
Tissue-specific signals control reversible program of localization and functional polarization of macrophages
10.1016/j.cell.2014.04.016 · 2014 · External reference
Revisiting mouse peritoneal macrophages: heterogeneity, development, and function
10.3389/fimmu.2015.00225 · 2015 · External reference
A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair
10.1016/j.cell.2016.03.009 · 2016 · External reference
Defective cholesterol clearance limits remyelination in the aged central nervous system
10.1126/science.aan4183 · 2018 · External reference
12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance
10.1016/j.immuni.2012.03.010 · 2012 · External reference
Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway
10.15252/embj.2019103454 · 2020 · External reference
Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E
10.1073/pnas.92.18.8264 · 1995 · External reference
Lysosomal lipid storage diseases
10.1101/cshperspect.a004804 · 2011 · External reference
Oxylipin metabolism is controlled by mitochondrial beta-oxidation during bacterial inflammation
10.1038/s41467-021-27766-8 · 2022 · External reference
A rapid method of total lipid extraction and purification
10.1139/o59-099 · 1959 · External reference
ProteoWizard: open source software for rapid proteomics tools development
10.1093/bioinformatics/btn323 · 2008 · External reference
Metabolic profiling of serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system
10.1016/j.jchromb.2008.03.021 · 2008 · External reference
Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers
10.1194/jlr.d800051-jlr200 · 2009 · External reference
Lentiviral Vector Preparation for Efficient Gene and MicroRNA Modulation of Peritoneal Cavity Tissue-Resident Macrophages In Vivo in Mice
10.3791/64926 · 2024 · External reference
Effective In Vivo Gene Modification in Mouse Tissue-Resident Peritoneal Macrophages by Intraperitoneal Delivery of Lentiviral Vectors
10.1016/j.omtm.2019.10.004 · 2020 · External reference
The myeloid 7/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B
10.1189/jlb.0809548 · 2010 · External reference
The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages
10.4049/jimmunol.169.7.3876 · 2002 · External reference
A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation
10.1002/eji.201141817 · 2011 · External reference
The induction of inflammation by dectin-1 in vivo is dependent on myeloid cell programming and the progression of phagocytosis
10.4049/jimmunol.181.5.3549 · 2008 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Quantitative chemical imaging and unsupervised analysis using hyperspectral coherent anti-Stokes Raman scattering microscopy
10.1021/ac402303g · 2013 · External reference
Bessel-Beam Hyperspectral CARS Microscopy with Sparse Sampling: Enabling High-Content High-Throughput Label-Free Quantitative Chemical Imaging
10.1021/acs.analchem.7b04039 · 2018 · External reference
Label-Free Volumetric Quantitative Imaging of the Human Somatic Cell Division by Hyperspectral Coherent Anti-Stokes Raman Scattering
10.1021/acs.analchem.8b04706 · 2019 · External reference
Quantitative Label-Free Imaging of Lipid Domains in Single Bilayers by Hyperspectral Coherent Raman Scattering
10.1021/acs.analchem.0c03179 · 2020 · External reference
Hyperspectral and differential CARS microscopy for quantitative chemical imaging in human adipocytes
10.1364/boe.5.001378 · 2014 · External reference
Quantitative Spatiotemporal Chemical Profiling of Individual Lipid Droplets by Hyperspectral CARS Microscopy in Living Human Adipose-Derived Stem Cells
10.1021/acs.analchem.5b04468 · 2016 · External reference
Identifying subpopulations in multicellular systems by quantitative chemical imaging using label-free hyperspectral CARS microscopy
10.1039/d0an02381g · 2021 · External reference
Sphingolipid Biosynthesis
10.1016/b978-0-12-378630-2.00515-6 · 2013 · External reference
Biochemical and imaging parameters in acid sphingomyelinase deficiency: Potential utility as biomarkers
10.1016/j.ymgme.2020.02.002 · 2020 · External reference
Acid sphingomyelinase, cell membranes and human disease: lessons from Niemann-Pick disease
10.1016/j.febslet.2009.11.083 · 2010 · External reference
Loss of function of glucocerebrosidase GBA2 is responsible for motor neuron defects in hereditary spastic paraplegia
10.1016/j.ajhg.2012.11.021 · 2013 · External reference
The Enigmatic Role of GBA2 in Controlling Locomotor Function
10.3389/fnmol.2017.00386 · 2017 · External reference
Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways
10.1016/j.jlr.2021.100121 · 2021 · External reference
Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2
10.1074/jbc.m309262200 · 2004 · External reference
Lactosylceramide-Induced Phosphorylation Signaling to Group IVA Phospholipase A(2) via Reactive Oxygen Species in Tumor Necrosis Factor-alpha-Treated Cells
10.1002/jcb.26091 · 2017 · External reference
Ceramide binds to the CaLB domain of cytosolic phospholipase A2 and facilitates its membrane docking and arachidonic acid release
10.1096/fj.00-0370fje · 2001 · External reference
Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine
10.1016/j.ejphar.2003.10.053 · 2004 · External reference
Eicosanoid storm in infection and inflammation
10.1038/nri3859 · 2015 · External reference
The Immunological Genome Project: networks of gene expression in immune cells
10.1038/ni1008-1091 · 2008 · External reference
Eosinophil secretion of granule-derived cytokines
10.3389/fimmu.2014.00496 · 2014 · External reference
Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils
10.1182/blood-2006-08-039255 · 2007 · External reference
Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages
10.1189/jlb.1106686 · 2007 · External reference
SiglecF+Gr1hi eosinophils are a distinct subpopulation within the lungs of allergen-challenged mice
10.1189/jlb.3a0416-166r · 2017 · External reference
Analysis of eosinophil turnover in vivo reveals their active recruitment to and prolonged survival in the peritoneal cavity
10.4049/jimmunol.179.7.4766 · 2007 · External reference
Eosinophil survival and apoptosis in health and disease
10.4168/aair.2010.2.2.87 · 2010 · External reference
PGE 2 and dibutyryl cyclic adenosine monophosphate prolong eosinophil survival in vitro
10.1016/s0091-6749(99)70127-2 · 1999 · External reference
Leukotriene receptor antagonists and synthesis inhibitors reverse survival in eosinophils of asthmatic individuals
10.1164/ajrccm.161.6.9907054 · 2000 · External reference
Treatment of asthmatic patients with a cysteinyl leukotriene receptor-1 antagonist montelukast (Singulair), decreases the eosinophil survival-enhancing activity produced by peripheral blood mononuclear leukocytes in vitro
10.1034/j.1398-9995.2002.23620.x · 2002 · External reference
Role of leukotrienes in the regulation of human granulocyte behaviour: dissociation between agonist-induced activation and retardation of apoptosis
10.1038/sj.bjp.0705265 · 2003 · External reference
Biological effects of leukotriene E4 on eosinophils
10.1016/j.plefa.2014.02.006 · 2014 · External reference
Types A and B Niemann-Pick disease
10.1016/j.ymgme.2016.12.008 · 2017 · External reference
Lysosomal storage disease overview
10.21037/atm.2018.11.39 · 2018 · External reference
High levels of urinary leukotriene E4 excretion in steroid treated patients with severe asthma
10.1016/s0954-6111(03)00253-1 · 2003 · External reference
Airway eosinophil migration into lymph nodes in mice depends on leukotriene C(4)
10.1111/all.13094 · 2017 · External reference
The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications
10.1016/j.jaci.2009.05.046 · 2009 · External reference
Characterization of the human cysteinyl leukotriene CysLT1 receptor
10.1038/21658 · 1999 · External reference
Leukotriene C4 Potentiates IL-33-Induced Group 2 Innate Lymphoid Cell Activation and Lung Inflammation
10.4049/jimmunol.1601569 · 2017 · External reference
The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects
10.1067/mai.2002.125000 · 2002 · External reference
Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity
10.1158/0008-5472.can-21-0839 · 2021 · External reference
Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration
10.1126/sciimmunol.abn3286 · 2022 · External reference
Eosinophils secrete IL-4 to facilitate liver regeneration
10.1073/pnas.1304046110 · 2013 · External reference
Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease
10.1111/j.1742-1241.2007.01320.x · 2007 · External reference
Simultaneous hyperspectral differential-CARS, TPF and SHG microscopy with a single 5 fs Ti:Sa laser
10.1364/oe.21.007096 · 2013 · External reference
Nomarski’s DIC microscopy: a review
10.1117/12.171873 · 1994 · External reference
Remodeling of lipid droplets during lipolysis and growth in adipocytes
10.1074/jbc.m111.316794 · 2012 · External reference
Coherent Anti-Stokes Raman Scattering Microscopy and Its Applications
10.3389/fphy.2020.598420 · 2020 · External reference
A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation
10.1002/eji.201141817 · ExternalCitation · doi-reference
Lactosylceramide-Induced Phosphorylation Signaling to Group IVA Phospholipase A(2) via Reactive Oxygen Species in Tumor Necrosis Factor-alpha-Treated Cells
10.1002/jcb.26091 · ExternalCitation · doi-reference
Sphingolipid Biosynthesis
10.1016/b978-0-12-378630-2.00515-6 · ExternalCitation · doi-reference
Loss of function of glucocerebrosidase GBA2 is responsible for motor neuron defects in hereditary spastic paraplegia
10.1016/j.ajhg.2012.11.021 · ExternalCitation · doi-reference
Tissue-specific signals control reversible program of localization and functional polarization of macrophages
10.1016/j.cell.2014.04.016 · ExternalCitation · doi-reference
A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair
10.1016/j.cell.2016.03.009 · ExternalCitation · doi-reference
Inhibition of arachidonic acid release and cytosolic phospholipase A2 alpha activity by D-erythro-sphingosine
10.1016/j.ejphar.2003.10.053 · ExternalCitation · doi-reference
Acid sphingomyelinase, cell membranes and human disease: lessons from Niemann-Pick disease
10.1016/j.febslet.2009.11.083 · ExternalCitation · doi-reference
12/15-lipoxygenase orchestrates the clearance of apoptotic cells and maintains immunologic tolerance
10.1016/j.immuni.2012.03.010 · ExternalCitation · doi-reference
Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis
10.1016/j.immuni.2012.12.001 · ExternalCitation · doi-reference
Tissue-Resident Macrophage Ontogeny and Homeostasis
10.1016/j.immuni.2016.02.024 · ExternalCitation · doi-reference
Establishment and Maintenance of the Macrophage Niche
10.1016/j.immuni.2020.02.015 · ExternalCitation · doi-reference
The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications
10.1016/j.jaci.2009.05.046 · ExternalCitation · doi-reference
Metabolic profiling of serum using Ultra Performance Liquid Chromatography and the LTQ-Orbitrap mass spectrometry system
10.1016/j.jchromb.2008.03.021 · ExternalCitation · doi-reference
Crosstalk between ORMDL3, serine palmitoyltransferase, and 5-lipoxygenase in the sphingolipid and eicosanoid metabolic pathways
10.1016/j.jlr.2021.100121 · ExternalCitation · doi-reference
Effective In Vivo Gene Modification in Mouse Tissue-Resident Peritoneal Macrophages by Intraperitoneal Delivery of Lentiviral Vectors
10.1016/j.omtm.2019.10.004 · ExternalCitation · doi-reference
Biological effects of leukotriene E4 on eosinophils
10.1016/j.plefa.2014.02.006 · ExternalCitation · doi-reference
Types A and B Niemann-Pick disease
10.1016/j.ymgme.2016.12.008 · ExternalCitation · doi-reference
Biochemical and imaging parameters in acid sphingomyelinase deficiency: Potential utility as biomarkers
10.1016/j.ymgme.2020.02.002 · ExternalCitation · doi-reference
PGE 2 and dibutyryl cyclic adenosine monophosphate prolong eosinophil survival in vitro
10.1016/s0091-6749(99)70127-2 · ExternalCitation · doi-reference
High levels of urinary leukotriene E4 excretion in steroid treated patients with severe asthma
10.1016/s0954-6111(03)00253-1 · ExternalCitation · doi-reference
Quantitative chemical imaging and unsupervised analysis using hyperspectral coherent anti-Stokes Raman scattering microscopy
10.1021/ac402303g · ExternalCitation · doi-reference
Quantitative Label-Free Imaging of Lipid Domains in Single Bilayers by Hyperspectral Coherent Raman Scattering
10.1021/acs.analchem.0c03179 · ExternalCitation · doi-reference
Quantitative Spatiotemporal Chemical Profiling of Individual Lipid Droplets by Hyperspectral CARS Microscopy in Living Human Adipose-Derived Stem Cells
10.1021/acs.analchem.5b04468 · ExternalCitation · doi-reference
Bessel-Beam Hyperspectral CARS Microscopy with Sparse Sampling: Enabling High-Content High-Throughput Label-Free Quantitative Chemical Imaging
10.1021/acs.analchem.7b04039 · ExternalCitation · doi-reference
Label-Free Volumetric Quantitative Imaging of the Human Somatic Cell Division by Hyperspectral Coherent Anti-Stokes Raman Scattering
10.1021/acs.analchem.8b04706 · ExternalCitation · doi-reference
Treatment of asthmatic patients with a cysteinyl leukotriene receptor-1 antagonist montelukast (Singulair), decreases the eosinophil survival-enhancing activity produced by peripheral blood mononuclear leukocytes in vitro
10.1034/j.1398-9995.2002.23620.x · ExternalCitation · doi-reference
Characterization of the human cysteinyl leukotriene CysLT1 receptor
10.1038/21658 · ExternalCitation · doi-reference
Tissue-resident macrophages
10.1038/ni.2705 · ExternalCitation · doi-reference
The Immunological Genome Project: networks of gene expression in immune cells
10.1038/ni1008-1091 · ExternalCitation · doi-reference
Eicosanoid storm in infection and inflammation
10.1038/nri3859 · ExternalCitation · doi-reference
Oxylipin metabolism is controlled by mitochondrial beta-oxidation during bacterial inflammation
10.1038/s41467-021-27766-8 · ExternalCitation · doi-reference
Role of leukotrienes in the regulation of human granulocyte behaviour: dissociation between agonist-induced activation and retardation of apoptosis
10.1038/sj.bjp.0705265 · ExternalCitation · doi-reference
Identifying subpopulations in multicellular systems by quantitative chemical imaging using label-free hyperspectral CARS microscopy
10.1039/d0an02381g · ExternalCitation · doi-reference
The effect of cysteinyl leukotrienes on growth of eosinophil progenitors from peripheral blood and bone marrow of atopic subjects
10.1067/mai.2002.125000 · ExternalCitation · doi-reference
Eosinophils secrete IL-4 to facilitate liver regeneration
10.1073/pnas.1304046110 · ExternalCitation · doi-reference
Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E
10.1073/pnas.92.18.8264 · ExternalCitation · doi-reference
Remodeling of lipid droplets during lipolysis and growth in adipocytes
10.1074/jbc.m111.316794 · ExternalCitation · doi-reference
Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2
10.1074/jbc.m309262200 · ExternalCitation · doi-reference
Gata6 regulates aspartoacylase expression in resident peritoneal macrophages and controls their survival
10.1084/jem.20140570 · ExternalCitation · doi-reference
ProteoWizard: open source software for rapid proteomics tools development
10.1093/bioinformatics/btn323 · ExternalCitation · doi-reference
Ceramide binds to the CaLB domain of cytosolic phospholipase A2 and facilitates its membrane docking and arachidonic acid release
10.1096/fj.00-0370fje · ExternalCitation · doi-reference
Lysosomal lipid storage diseases
10.1101/cshperspect.a004804 · ExternalCitation · doi-reference
Airway eosinophil migration into lymph nodes in mice depends on leukotriene C(4)
10.1111/all.13094 · ExternalCitation · doi-reference
Zileuton: clinical implications of 5-Lipoxygenase inhibition in severe airway disease
10.1111/j.1742-1241.2007.01320.x · ExternalCitation · doi-reference
Nomarski’s DIC microscopy: a review
10.1117/12.171873 · ExternalCitation · doi-reference
The transcription factor Gata6 links tissue macrophage phenotype and proliferative renewal
10.1126/science.1251414 · ExternalCitation · doi-reference
Defective cholesterol clearance limits remyelination in the aged central nervous system
10.1126/science.aan4183 · ExternalCitation · doi-reference
Eosinophils are an essential element of a type 2 immune axis that controls thymus regeneration
10.1126/sciimmunol.abn3286 · ExternalCitation · doi-reference
A rapid method of total lipid extraction and purification
10.1139/o59-099 · ExternalCitation · doi-reference
Metastasis-Entrained Eosinophils Enhance Lymphocyte-Mediated Antitumor Immunity
10.1158/0008-5472.can-21-0839 · ExternalCitation · doi-reference
Leukotriene receptor antagonists and synthesis inhibitors reverse survival in eosinophils of asthmatic individuals
10.1164/ajrccm.161.6.9907054 · ExternalCitation · doi-reference
Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils
10.1182/blood-2006-08-039255 · ExternalCitation · doi-reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · ExternalCitation · doi-reference
The myeloid 7/4-antigen defines recently generated inflammatory macrophages and is synonymous with Ly-6B
10.1189/jlb.0809548 · ExternalCitation · doi-reference
Eosinophils develop in distinct stages and are recruited to peripheral sites by alternatively activated macrophages
10.1189/jlb.1106686 · ExternalCitation · doi-reference
SiglecF+Gr1hi eosinophils are a distinct subpopulation within the lungs of allergen-challenged mice
10.1189/jlb.3a0416-166r · ExternalCitation · doi-reference
Quantitative analysis of sphingolipids for lipidomics using triple quadrupole and quadrupole linear ion trap mass spectrometers
10.1194/jlr.d800051-jlr200 · ExternalCitation · doi-reference
Hyperspectral and differential CARS microscopy for quantitative chemical imaging in human adipocytes
10.1364/boe.5.001378 · ExternalCitation · doi-reference
Simultaneous hyperspectral differential-CARS, TPF and SHG microscopy with a single 5 fs Ti:Sa laser
10.1364/oe.21.007096 · ExternalCitation · doi-reference
Tissue-resident macrophages actively suppress IL-1beta release via a reactive prostanoid/IL-10 pathway
10.15252/embj.2019103454 · ExternalCitation · doi-reference
Lysosomal storage disease overview
10.21037/atm.2018.11.39 · ExternalCitation · doi-reference
Eosinophil secretion of granule-derived cytokines
10.3389/fimmu.2014.00496 · ExternalCitation · doi-reference
Revisiting mouse peritoneal macrophages: heterogeneity, development, and function
10.3389/fimmu.2015.00225 · ExternalCitation · doi-reference
The Enigmatic Role of GBA2 in Controlling Locomotor Function
10.3389/fnmol.2017.00386 · ExternalCitation · doi-reference
Coherent Anti-Stokes Raman Scattering Microscopy and Its Applications
10.3389/fphy.2020.598420 · ExternalCitation · doi-reference
Lentiviral Vector Preparation for Efficient Gene and MicroRNA Modulation of Peritoneal Cavity Tissue-Resident Macrophages In Vivo in Mice
10.3791/64926 · ExternalCitation · doi-reference
Leukotriene C4 Potentiates IL-33-Induced Group 2 Innate Lymphoid Cell Activation and Lung Inflammation
10.4049/jimmunol.1601569 · ExternalCitation · doi-reference
The beta-glucan receptor, dectin-1, is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages
10.4049/jimmunol.169.7.3876 · ExternalCitation · doi-reference
Analysis of eosinophil turnover in vivo reveals their active recruitment to and prolonged survival in the peritoneal cavity
10.4049/jimmunol.179.7.4766 · ExternalCitation · doi-reference
The induction of inflammation by dectin-1 in vivo is dependent on myeloid cell programming and the progression of phagocytosis
10.4049/jimmunol.181.5.3549 · ExternalCitation · doi-reference
Eosinophil survival and apoptosis in health and disease
10.4168/aair.2010.2.2.87 · ExternalCitation · doi-reference
