Research graph
References from Break-induced replication drives large-scale genomic amplifications in cancer cells. Local targets link to admitted publications; unresolved targets remain external evidence.
DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy
10.3389/fonc.2013.00113 · 2013 · External reference
Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining
10.1016/j.ijrobp.2013.01.011 · 2013 · External reference
Ionizing radiation-induced DNA damage, response, and repair
10.1089/ars.2013.5668 · 2014 · External reference
Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks
10.1371/journal.pone.0049211 · 2012 · External reference
SET8 methyltransferase activity during the DNA double-strand break response is required for recruitment of 53BP1
10.15252/embr.201439434 · 2014 · External reference
Concerted activities of distinct H4K20 methyltransferases at DNA double-strand breaks regulate 53BP1 nucleation and NHEJ-directed repair
10.1016/j.celrep.2014.06.013 · 2014 · External reference
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity
10.1016/j.cell.2018.03.050 · 2018 · External reference
Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells
10.1038/s41556-018-0140-1 · 2018 · External reference
53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polalpha-dependent fill-in
10.1038/s41586-018-0324-7 · 2018 · External reference
The shieldin complex mediates 53BP1-dependent DNA repair
10.1038/s41586-018-0340-7 · 2018 · External reference
53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ
10.1038/s41586-018-0362-1 · 2018 · External reference
The Neddylation Inhibitor Pevonedistat (MLN4924) Suppresses and Radiosensitizes Head and Neck Squamous Carcinoma Cells and Tumors
10.1158/1535-7163.mct-17-0083 · 2017 · External reference
A p53-dependent checkpoint pathway prevents rereplication
10.1016/s1097-2765(03)00099-6 · 2003 · External reference
Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts
10.1101/gad.1255805 · 2005 · External reference
Break-induced replication repair of damaged forks induces genomic duplications in human cells
10.1126/science.1243211 · 2014 · External reference
Break-induced replication: what is it and what is it for?
10.4161/cc.7.7.5613 · 2008 · External reference
Break-Induced Replication: The Where, The Why, and The How
10.1016/j.tig.2018.04.002 · 2018 · External reference
Break-induced replication occurs by conservative DNA synthesis
10.1073/pnas.1309800110 · 2013 · External reference
Migrating bubble during break-induced replication drives conservative DNA synthesis
10.1038/nature12584 · 2013 · External reference
Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis
10.3390/cancers9070091 · 2017 · External reference
Radiation-induced clustered DNA lesions: Repair and mutagenesis
10.1016/j.freeradbiomed.2016.12.008 · 2017 · External reference
High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome
10.1038/emboj.2010.38 · 2010 · External reference
Deciphering the chromatin landscape induced around DNA double strand breaks
10.4161/cc.9.15.12412 · 2010 · External reference
Quantitation of DNA double-strand break resection intermediates in human cells
10.1093/nar/gkt1309 · 2014 · External reference
CRL4Cdt2: master coordinator of cell cycle progression and genome stability
10.4161/cc.10.2.14530 · 2011 · External reference
Genomic instability in cancer
10.1101/cshperspect.a012914 · 2013 · External reference
CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation
10.1016/j.molcel.2010.09.014 · 2010 · External reference
Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma
10.1016/j.ebiom.2016.06.023 · 2016 · External reference
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
10.1101/gad.1676108 · 2008 · External reference
Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage
10.1016/j.molcel.2010.10.011 · 2010 · External reference
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation
10.1083/jcb.201009076 · 2011 · External reference
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
10.1038/nature07884 · 2009 · External reference
NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells
10.1158/0008-5472.can-10-2062 · 2010 · External reference
Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor
10.1158/0008-5472.can-11-2866 · 2012 · External reference
Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924
10.1158/1535-7163.mct-12-1028 · 2013 · External reference
Regulation of cullin-RING E3 ubiquitin-ligases by neddylation and dimerization
10.1007/s00018-009-8712-7 · 2009 · External reference
MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma
10.1182/blood-2010-03-272567 · 2010 · External reference
Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover
10.1158/0008-5472.can-10-2122 · 2011 · External reference
MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells
10.1182/blood-2013-08-521914 · 2014 · External reference
The Nedd8-activating enzyme inhibitor MLN4924 thwarts microenvironment-driven NF-kappaB activation and induces apoptosis in chronic lymphocytic leukemia B cells
10.1158/1078-0432.ccr-13-0987 · 2014 · External reference
Overactivated neddylation pathway as a therapeutic target in lung cancer
10.1093/jnci/dju083 · 2014 · External reference
Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis
10.1172/jci70297 · 2014 · External reference
PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin
10.1016/s1097-2765(02)00548-8 · 2002 · External reference
Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development
10.1128/mcb.01768-08 · 2009 · External reference
The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells
10.1038/ncb2113 · 2010 · External reference
The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome
10.1038/nature10956 · 2012 · External reference
The role of PR-Set7 in replication licensing depends on Suv4-20h
10.1101/gad.195636.112 · 2012 · External reference
Two subunits of human ORC are dispensable for DNA replication and proliferation
10.7554/elife.19084 · 2016 · External reference
Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cells
10.1093/nar/gkp221 · 2009 · External reference
Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair
10.1073/pnas.1420115112 · 2015 · External reference
A human XRCC4-XLF complex bridges DNA
10.1093/nar/gks022 · 2012 · External reference
Non-homologous DNA end joining and alternative pathways to double-strand break repair
10.1038/nrm.2017.48 · 2017 · External reference
Mammalian polymerase theta promotes alternative NHEJ and suppresses recombination
10.1038/nature14157 · 2015 · External reference
Double-strand break repair: 53BP1 comes into focus
10.1038/nrm3719 · 2014 · External reference
Use of selected reaction monitoring mass spectrometry for the detection of specific MHC class I peptide antigens on A3 supertype family members
10.1007/s00262-004-0592-y · 2005 · External reference
Recognition of human melanoma cells by HLA-A2.1-restricted cytotoxic T lymphocytes is mediated by at least six shared peptide epitopes
10.4049/jimmunol.150.7.2955 · 1993 · External reference
Human melanoma cytolysis by combined inhibition of mammalian target of rapamycin and vascular endothelial growth factor/vascular endothelial growth factor receptor-2
10.1158/0008-5472.can-07-5844 · 2008 · External reference
Analysis of a natural immune response against tumor antigens in a melanoma survivor: lessons applicable to clinical trial evaluations
2001 · External reference
Sequential immune escape and shifting of T cell responses in a long-term survivor of melanoma
10.4049/jimmunol.174.11.6863 · 2005 · External reference
Human melanoma patients recognize an HLA-A1-restricted CTL epitope from tyrosinase containing two cysteine residues: implications for tumor vaccine development
10.4049/jimmunol.160.5.2099 · 1998 · External reference
Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling
10.1074/jbc.m405102200 · 2004 · External reference
PIG3V, an immortalized human vitiligo melanocyte cell line, expresses dilated endoplasmic reticulum
10.1290/1071-2690(2000)036<0309:paihvm>2.0.co;2 · 2000 · External reference
Regulation of cullin-RING E3 ubiquitin-ligases by neddylation and dimerization
10.1007/s00018-009-8712-7 · ExternalCitation · doi-reference
Use of selected reaction monitoring mass spectrometry for the detection of specific MHC class I peptide antigens on A3 supertype family members
10.1007/s00262-004-0592-y · ExternalCitation · doi-reference
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity
10.1016/j.cell.2018.03.050 · ExternalCitation · doi-reference
Concerted activities of distinct H4K20 methyltransferases at DNA double-strand breaks regulate 53BP1 nucleation and NHEJ-directed repair
10.1016/j.celrep.2014.06.013 · ExternalCitation · doi-reference
Inactivation of the CRL4-CDT2-SET8/p21 ubiquitylation and degradation axis underlies the therapeutic efficacy of pevonedistat in melanoma
10.1016/j.ebiom.2016.06.023 · ExternalCitation · doi-reference
Radiation-induced clustered DNA lesions: Repair and mutagenesis
10.1016/j.freeradbiomed.2016.12.008 · ExternalCitation · doi-reference
Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining
10.1016/j.ijrobp.2013.01.011 · ExternalCitation · doi-reference
CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation
10.1016/j.molcel.2010.09.014 · ExternalCitation · doi-reference
Regulation of the histone H4 monomethylase PR-Set7 by CRL4(Cdt2)-mediated PCNA-dependent degradation during DNA damage
10.1016/j.molcel.2010.10.011 · ExternalCitation · doi-reference
Break-Induced Replication: The Where, The Why, and The How
10.1016/j.tig.2018.04.002 · ExternalCitation · doi-reference
PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin
10.1016/s1097-2765(02)00548-8 · ExternalCitation · doi-reference
A p53-dependent checkpoint pathway prevents rereplication
10.1016/s1097-2765(03)00099-6 · ExternalCitation · doi-reference
High-resolution profiling of gammaH2AX around DNA double strand breaks in the mammalian genome
10.1038/emboj.2010.38 · ExternalCitation · doi-reference
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer
10.1038/nature07884 · ExternalCitation · doi-reference
The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome
10.1038/nature10956 · ExternalCitation · doi-reference
Migrating bubble during break-induced replication drives conservative DNA synthesis
10.1038/nature12584 · ExternalCitation · doi-reference
Mammalian polymerase theta promotes alternative NHEJ and suppresses recombination
10.1038/nature14157 · ExternalCitation · doi-reference
The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells
10.1038/ncb2113 · ExternalCitation · doi-reference
Non-homologous DNA end joining and alternative pathways to double-strand break repair
10.1038/nrm.2017.48 · ExternalCitation · doi-reference
Double-strand break repair: 53BP1 comes into focus
10.1038/nrm3719 · ExternalCitation · doi-reference
Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells
10.1038/s41556-018-0140-1 · ExternalCitation · doi-reference
53BP1-RIF1-shieldin counteracts DSB resection through CST- and Polalpha-dependent fill-in
10.1038/s41586-018-0324-7 · ExternalCitation · doi-reference
The shieldin complex mediates 53BP1-dependent DNA repair
10.1038/s41586-018-0340-7 · ExternalCitation · doi-reference
53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ
10.1038/s41586-018-0362-1 · ExternalCitation · doi-reference
Break-induced replication occurs by conservative DNA synthesis
10.1073/pnas.1309800110 · ExternalCitation · doi-reference
Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair
10.1073/pnas.1420115112 · ExternalCitation · doi-reference
Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling
10.1074/jbc.m405102200 · ExternalCitation · doi-reference
SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation
10.1083/jcb.201009076 · ExternalCitation · doi-reference
Ionizing radiation-induced DNA damage, response, and repair
10.1089/ars.2013.5668 · ExternalCitation · doi-reference
Overactivated neddylation pathway as a therapeutic target in lung cancer
10.1093/jnci/dju083 · ExternalCitation · doi-reference
Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cells
10.1093/nar/gkp221 · ExternalCitation · doi-reference
A human XRCC4-XLF complex bridges DNA
10.1093/nar/gks022 · ExternalCitation · doi-reference
Quantitation of DNA double-strand break resection intermediates in human cells
10.1093/nar/gkt1309 · ExternalCitation · doi-reference
Genomic instability in cancer
10.1101/cshperspect.a012914 · ExternalCitation · doi-reference
Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts
10.1101/gad.1255805 · ExternalCitation · doi-reference
PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex
10.1101/gad.1676108 · ExternalCitation · doi-reference
The role of PR-Set7 in replication licensing depends on Suv4-20h
10.1101/gad.195636.112 · ExternalCitation · doi-reference
Break-induced replication repair of damaged forks induces genomic duplications in human cells
10.1126/science.1243211 · ExternalCitation · doi-reference
Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development
10.1128/mcb.01768-08 · ExternalCitation · doi-reference
Human melanoma cytolysis by combined inhibition of mammalian target of rapamycin and vascular endothelial growth factor/vascular endothelial growth factor receptor-2
10.1158/0008-5472.can-07-5844 · ExternalCitation · doi-reference
NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells
10.1158/0008-5472.can-10-2062 · ExternalCitation · doi-reference
Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover
10.1158/0008-5472.can-10-2122 · ExternalCitation · doi-reference
Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor
10.1158/0008-5472.can-11-2866 · ExternalCitation · doi-reference
The Nedd8-activating enzyme inhibitor MLN4924 thwarts microenvironment-driven NF-kappaB activation and induces apoptosis in chronic lymphocytic leukemia B cells
10.1158/1078-0432.ccr-13-0987 · ExternalCitation · doi-reference
Overcoming platinum resistance in preclinical models of ovarian cancer using the neddylation inhibitor MLN4924
10.1158/1535-7163.mct-12-1028 · ExternalCitation · doi-reference
The Neddylation Inhibitor Pevonedistat (MLN4924) Suppresses and Radiosensitizes Head and Neck Squamous Carcinoma Cells and Tumors
10.1158/1535-7163.mct-17-0083 · ExternalCitation · doi-reference
Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis
10.1172/jci70297 · ExternalCitation · doi-reference
MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma
10.1182/blood-2010-03-272567 · ExternalCitation · doi-reference
MLN4924, an NAE inhibitor, suppresses AKT and mTOR signaling via upregulation of REDD1 in human myeloma cells
10.1182/blood-2013-08-521914 · ExternalCitation · doi-reference
PIG3V, an immortalized human vitiligo melanocyte cell line, expresses dilated endoplasmic reticulum
10.1290/1071-2690(2000)036<0309:paihvm>2.0.co;2 · ExternalCitation · doi-reference
Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks
10.1371/journal.pone.0049211 · ExternalCitation · doi-reference
SET8 methyltransferase activity during the DNA double-strand break response is required for recruitment of 53BP1
10.15252/embr.201439434 · ExternalCitation · doi-reference
DNA double-strand break repair as determinant of cellular radiosensitivity to killing and target in radiation therapy
10.3389/fonc.2013.00113 · ExternalCitation · doi-reference
Complex DNA Damage: A Route to Radiation-Induced Genomic Instability and Carcinogenesis
10.3390/cancers9070091 · ExternalCitation · doi-reference
Recognition of human melanoma cells by HLA-A2.1-restricted cytotoxic T lymphocytes is mediated by at least six shared peptide epitopes
10.4049/jimmunol.150.7.2955 · ExternalCitation · doi-reference
Human melanoma patients recognize an HLA-A1-restricted CTL epitope from tyrosinase containing two cysteine residues: implications for tumor vaccine development
10.4049/jimmunol.160.5.2099 · ExternalCitation · doi-reference
Sequential immune escape and shifting of T cell responses in a long-term survivor of melanoma
10.4049/jimmunol.174.11.6863 · ExternalCitation · doi-reference
CRL4Cdt2: master coordinator of cell cycle progression and genome stability
10.4161/cc.10.2.14530 · ExternalCitation · doi-reference
Break-induced replication: what is it and what is it for?
10.4161/cc.7.7.5613 · ExternalCitation · doi-reference
Deciphering the chromatin landscape induced around DNA double strand breaks
10.4161/cc.9.15.12412 · ExternalCitation · doi-reference
Two subunits of human ORC are dispensable for DNA replication and proliferation
10.7554/elife.19084 · ExternalCitation · doi-reference
