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References from The P2X7 receptor is an intermediate in the retinoic acid-signaling pathway that induces neuronal remodeling in retinitis pigmentosa. Local targets link to admitted publications; unresolved targets remain external evidence.
Clinical Impact of Spontaneous Hyperactivity in Degenerating Retinas: Significance for Diagnosis, Symptoms, and Treatment
10.3389/fncel.2018.00298 · 2018 · External reference
Retinoic acid inhibitors mitigate vision loss in a mouse model of retinal degeneration
10.1126/sciadv.abm4643 · 2022 · External reference
Mature Retina Compensates Functionally for Partial Loss of Rod Photoreceptors
10.1016/j.celrep.2020.107730 · 2020 · External reference
Partial Cone Loss Triggers Synapse-Specific Remodeling and Spatial Receptive Field Rearrangements in a Mature Retinal Circuit
10.1016/j.celrep.2019.04.065 · 2019 · External reference
Homeostatic plasticity in the retina
10.1016/j.preteyeres.2022.101131 · 2023 · External reference
Retinoic Acid-Dependent Loss of Synaptic Output from Bipolar Cells Impairs Visual Information Processing in Inherited Retinal Degeneration
10.1523/jneurosci.0129-24.2024 · 2024 · External reference
Retinoic Acid Induces Hyperactivity, and Blocking Its Receptor Unmasks Light Responses and Augments Vision in Retinal Degeneration
10.1016/j.neuron.2019.02.015 · 2019 · External reference
Retinoic acid in the development, regeneration and maintenance of the nervous system
10.1038/nrn2212 · 2007 · External reference
Genetics and functions of the retinoic acid pathway, with special emphasis on the eye
10.1186/s40246-019-0248-9 · 2019 · External reference
Synaptic retinoic acid signaling and homeostatic synaptic plasticity
10.1016/j.neuropharm.2012.12.004 · 2014 · External reference
Non-canonical retinoid signaling in neural development, regeneration and synaptic function
10.3389/fnmol.2024.1371135 · 2024 · External reference
Non-canonical activity of retinoic acid in epigenetic control of embryonic stem cell
10.4161/trns.25395 · 2013 · External reference
How Azobenzene Photoswitches Restore Visual Responses to the Blind Retina
10.1016/j.neuron.2016.08.038 · 2016 · External reference
P2X7/P2Z purinoreceptor-mediated activation of transcription factor NFAT in microglial cells
10.1074/jbc.274.19.13205 · 1999 · External reference
P2X7 receptor antagonism inhibits p38 mitogen-activated protein kinase activation and ameliorates neuronal apoptosis after subarachnoid hemorrhage in rats
10.1097/ccm.0b013e31829a8246 · 2013 · External reference
Purinergic Receptors P2X7 and P2X4 as Markers of Disease Progression in the rd10 Mouse Model of Inherited Retinal Dystrophy
10.3390/ijms232314758 · 2022 · External reference
The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina
10.1002/cne.23521 · 2014 · External reference
RNA binding protein with multiple splicing: a new marker for retinal ganglion cells
10.1167/iovs.09-4098 · 2010 · External reference
Differential Distribution of RBPMS in Pig, Rat, and Human Retina after Damage
10.3390/ijms21239330 · 2020 · External reference
Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN
10.1093/nar/gkg605 · 2003 · External reference
PROMO: detection of known transcription regulatory elements using species-tailored searches
10.1093/bioinformatics/18.2.333 · 2002 · External reference
Local photoreceptor degeneration causes local pathophysiological remodeling of retinal neurons
10.1172/jci.insight.132114 · 2020 · External reference
The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses
10.1002/cpbi.5 · 2016 · External reference
Thy1 associates with the cation channel subunit HCN4 in adult rat retina
10.1167/iovs.11-9307 · 2012 · External reference
Directional summation in non-direction selective retinal ganglion cells
10.1371/journal.pcbi.1002969 · 2013 · External reference
Dopaminergic amacrine cells express HCN channels in the developing and adult mouse retina
10.1101/2024.07.20.604440 · 2024 · External reference
Neuronal Ryanodine Receptors in Development and Aging
10.1007/s12035-016-0375-4 · 2018 · External reference
Localization and phenotype-specific expression of ryanodine calcium release channels in C57BL6 and DBA/2J mouse strains
10.1016/j.exer.2011.09.001 · 2011 · External reference
Novel ryanodine-binding properties in mammalian retina
10.1016/j.biocel.2005.03.001 · 2005 · External reference
Two separate Ni(2+) -sensitive voltage-gated Ca(2+) channels modulate transretinal signalling in the isolated murine retina
10.1111/j.1755-3768.2011.02167.x · 2011 · External reference
Expression of CaV3.2 T-type Ca(2)(+) channels in a subpopulation of retinal type-3 cone bipolar cells
10.1016/j.neuroscience.2012.08.017 · 2012 · External reference
CaV3.2 KO mice have altered retinal waves but normal direction selectivity
10.1017/s0952523814000364 · 2015 · External reference
Ultrasensitive fluorescent proteins for imaging neuronal activity
10.1038/nature12354 · 2013 · External reference
Purinergic signalling
10.1038/sj.bjp.0706429 · 2006 · External reference
Purinergic signaling in retinal degeneration and regeneration
10.1016/j.neuropharm.2015.05.005 · 2016 · External reference
Purinergic signaling in the retina: From development to disease
10.1016/j.brainresbull.2018.10.016 · 2019 · External reference
Purinergic signaling via P2X receptors and mechanisms of unregulated ATP release in the outer retina and age-related macular degeneration
10.3389/fnins.2023.1216489 · 2023 · External reference
Role of Purines in Muller Glia
10.1089/jop.2016.0131 · 2016 · External reference
Release of ATP from avian Muller glia cells in culture
10.1016/j.neuint.2010.12.019 · 2011 · External reference
Targeted P2X7/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy
10.1038/s41419-022-04786-w · 2022 · External reference
Role of P2X7R in Retinal Diseases: A Review
10.1002/iid3.70203 · 2025 · External reference
Potential role of P2X7 receptor in neurodegenerative processes in a murine model of glaucoma
10.1016/j.brainresbull.2019.05.006 · 2019 · External reference
P2X7 receptor antagonism preserves retinal ganglion cells in glaucomatous mice
10.1016/j.bcp.2020.114199 · 2020 · External reference
Unveiling the P2X7 receptor: Exploring its mechanisms, pathogenic role in ocular diseases, and emerging therapeutic potential
10.1016/j.mam.2025.101389 · 2025 · External reference
Therapeutic potential of P2X7 receptor in retinal diseases
10.1007/s11302-025-10104-8 · 2025 · External reference
P2X7 Is Involved in the Mouse Retinal Degeneration via the Coordinated Actions in Different Retinal Cell Types
10.3390/antiox12010141 · 2023 · External reference
Synaptic memory and CaMKII
10.1152/physrev.00034.2022 · 2023 · External reference
Regulation of NMDA receptor Ca2+ signalling and synaptic plasticity
10.1042/bst0371369 · 2009 · External reference
The NMDA receptor complex: a multifunctional machine at the glutamatergic synapse
10.3389/fncel.2014.00160 · 2014 · External reference
Molecular mechanisms associated with long-term consolidation of the NMDA signals
10.1016/s0024-3205(00)00632-9 · 2000 · External reference
Activation of a metabotropic glutamate receptor increases intracellular calcium concentrations in neurons of the avian cochlear nucleus
10.1523/jneurosci.15-01-00214.1995 · 1995 · External reference
Intracellular calcium is regulated by different pathways in horizontal cells of the mouse retina
10.1152/jn.00191.2006 · 2006 · External reference
Metabotropic glutamate receptor dependent long-term depression in the cortex
10.4196/kjpp.2016.20.6.557 · 2016 · External reference
A G protein-coupled alpha7 nicotinic receptor regulates signaling and TNF-alpha release in microglia
10.1002/2211-5463.12270 · 2017 · External reference
alpha7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum
10.1007/978-94-007-2888-2_27 · 2012 · External reference
Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system
10.1038/aps.2009.64 · 2009 · External reference
Communication between the synapse and the nucleus in neuronal development, plasticity, and disease
10.1146/annurev.cellbio.24.110707.175235 · 2008 · External reference
Calcium regulation of neuronal gene expression
10.1073/pnas.191352298 · 2001 · External reference
Contribution of calcium ions to P2X channel responses
10.1523/jneurosci.5429-03.2004 · 2004 · External reference
P2X(7) receptor stimulation upregulates Egr-1 biosynthesis involving a cytosolic Ca(2+) rise, transactivation of the EGF receptor and phosphorylation of ERK and Elk-1
10.1002/jcp.21085 · 2007 · External reference
Unlocking the therapeutic potential of P2X7 receptor: a comprehensive review of its role in neurodegenerative disorders
10.3389/fphar.2024.1450704 · 2024 · External reference
Pleiotropic Roles of P2X7 in the Central Nervous System
10.3389/fncel.2019.00401 · 2019 · External reference
Structural MRI Differences between Patients with and without First Rank Symptoms: A Delusion?
10.3389/fpsyt.2015.00107 · 2015 · External reference
Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions
10.1007/s12026-011-8203-4 · 2011 · External reference
Enlightening activation gating in P2X receptors
10.1007/s11302-022-09850-w · 2022 · External reference
Evidence for the involvement of purinergic P2X receptors in outer retinal processing
10.1111/j.1460-9568.2006.04895.x · 2006 · External reference
P2X7 receptors in Muller glial cells from the human retina
10.1523/jneurosci.20-16-05965.2000 · 2000 · External reference
P2X(7) receptor activation may be involved in neuronal loss in the retinal ganglion cell layer after acute elevation of intraocular pressure in rats
2013 · External reference
Purinergic signalling in the subretinal space: a role in the communication between the retina and the RPE
10.1007/s11302-007-9054-2 · 2008 · External reference
P2X7 receptor antagonist protects retinal ganglion cells by inhibiting microglial activation in a rat chronic ocular hypertension model
10.3892/mmr.2017.8137 · 2018 · External reference
The role of purinergic receptors in retinal function and disease
10.1007/978-1-4419-1399-9_44 · 2010 · External reference
Identification of New Human P2X7 Antagonists Using Ligand- and Structure-Based Virtual Screening
10.1021/acs.jcim.5c00552 · 2025 · External reference
Density-dependent changes of the pore properties of the P2X2 receptor channel
10.1113/jphysiol.2004.064568 · 2004 · External reference
On the permeation of large organic cations through the pore of ATP-gated P2X receptors
10.1073/pnas.1701379114 · 2017 · External reference
Modulation of P2X4 pore closure by magnesium, potassium, and ATP
10.1016/j.bpj.2022.02.038 · 2022 · External reference
Late gene therapy limits the restoration of retinal function in a mouse model of retinitis pigmentosa
10.1038/s41467-023-44063-8 · 2023 · External reference
Persistent remodeling and neurodegeneration in late-stage retinal degeneration
10.1016/j.preteyeres.2019.07.004 · 2020 · External reference
Retinal prosthetics, optogenetics, and chemical photoswitches
10.1021/cn5001233 · 2014 · External reference
Opsins for vision restoration
10.1016/j.bbrc.2019.12.117 · 2020 · External reference
Degeneration-Dependent Retinal Remodeling: Looking for the Molecular Trigger
10.3389/fnins.2020.618019 · 2020 · External reference
The P2X7 receptor is an intermediate in the retinoic acid-signaling pathway that induces neuronal remodeling in retinitis pigmentosa
2026 · External reference
A G protein-coupled alpha7 nicotinic receptor regulates signaling and TNF-alpha release in microglia
10.1002/2211-5463.12270 · ExternalCitation · doi-reference
The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina
10.1002/cne.23521 · ExternalCitation · doi-reference
The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses
10.1002/cpbi.5 · ExternalCitation · doi-reference
Role of P2X7R in Retinal Diseases: A Review
10.1002/iid3.70203 · ExternalCitation · doi-reference
P2X(7) receptor stimulation upregulates Egr-1 biosynthesis involving a cytosolic Ca(2+) rise, transactivation of the EGF receptor and phosphorylation of ERK and Elk-1
10.1002/jcp.21085 · ExternalCitation · doi-reference
The role of purinergic receptors in retinal function and disease
10.1007/978-1-4419-1399-9_44 · ExternalCitation · doi-reference
alpha7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum
10.1007/978-94-007-2888-2_27 · ExternalCitation · doi-reference
Purinergic signalling in the subretinal space: a role in the communication between the retina and the RPE
10.1007/s11302-007-9054-2 · ExternalCitation · doi-reference
Enlightening activation gating in P2X receptors
10.1007/s11302-022-09850-w · ExternalCitation · doi-reference
Therapeutic potential of P2X7 receptor in retinal diseases
10.1007/s11302-025-10104-8 · ExternalCitation · doi-reference
Transcriptional control mechanisms associated with the nucleotide receptor P2X7, a critical regulator of immunologic, osteogenic, and neurologic functions
10.1007/s12026-011-8203-4 · ExternalCitation · doi-reference
Neuronal Ryanodine Receptors in Development and Aging
10.1007/s12035-016-0375-4 · ExternalCitation · doi-reference
Opsins for vision restoration
10.1016/j.bbrc.2019.12.117 · ExternalCitation · doi-reference
P2X7 receptor antagonism preserves retinal ganglion cells in glaucomatous mice
10.1016/j.bcp.2020.114199 · ExternalCitation · doi-reference
Novel ryanodine-binding properties in mammalian retina
10.1016/j.biocel.2005.03.001 · ExternalCitation · doi-reference
Modulation of P2X4 pore closure by magnesium, potassium, and ATP
10.1016/j.bpj.2022.02.038 · ExternalCitation · doi-reference
Purinergic signaling in the retina: From development to disease
10.1016/j.brainresbull.2018.10.016 · ExternalCitation · doi-reference
Potential role of P2X7 receptor in neurodegenerative processes in a murine model of glaucoma
10.1016/j.brainresbull.2019.05.006 · ExternalCitation · doi-reference
Partial Cone Loss Triggers Synapse-Specific Remodeling and Spatial Receptive Field Rearrangements in a Mature Retinal Circuit
10.1016/j.celrep.2019.04.065 · ExternalCitation · doi-reference
Mature Retina Compensates Functionally for Partial Loss of Rod Photoreceptors
10.1016/j.celrep.2020.107730 · ExternalCitation · doi-reference
Localization and phenotype-specific expression of ryanodine calcium release channels in C57BL6 and DBA/2J mouse strains
10.1016/j.exer.2011.09.001 · ExternalCitation · doi-reference
Unveiling the P2X7 receptor: Exploring its mechanisms, pathogenic role in ocular diseases, and emerging therapeutic potential
10.1016/j.mam.2025.101389 · ExternalCitation · doi-reference
Release of ATP from avian Muller glia cells in culture
10.1016/j.neuint.2010.12.019 · ExternalCitation · doi-reference
How Azobenzene Photoswitches Restore Visual Responses to the Blind Retina
10.1016/j.neuron.2016.08.038 · ExternalCitation · doi-reference
Retinoic Acid Induces Hyperactivity, and Blocking Its Receptor Unmasks Light Responses and Augments Vision in Retinal Degeneration
10.1016/j.neuron.2019.02.015 · ExternalCitation · doi-reference
Synaptic retinoic acid signaling and homeostatic synaptic plasticity
10.1016/j.neuropharm.2012.12.004 · ExternalCitation · doi-reference
Purinergic signaling in retinal degeneration and regeneration
10.1016/j.neuropharm.2015.05.005 · ExternalCitation · doi-reference
Expression of CaV3.2 T-type Ca(2)(+) channels in a subpopulation of retinal type-3 cone bipolar cells
10.1016/j.neuroscience.2012.08.017 · ExternalCitation · doi-reference
Persistent remodeling and neurodegeneration in late-stage retinal degeneration
10.1016/j.preteyeres.2019.07.004 · ExternalCitation · doi-reference
Homeostatic plasticity in the retina
10.1016/j.preteyeres.2022.101131 · ExternalCitation · doi-reference
Molecular mechanisms associated with long-term consolidation of the NMDA signals
10.1016/s0024-3205(00)00632-9 · ExternalCitation · doi-reference
CaV3.2 KO mice have altered retinal waves but normal direction selectivity
10.1017/s0952523814000364 · ExternalCitation · doi-reference
Identification of New Human P2X7 Antagonists Using Ligand- and Structure-Based Virtual Screening
10.1021/acs.jcim.5c00552 · ExternalCitation · doi-reference
Retinal prosthetics, optogenetics, and chemical photoswitches
10.1021/cn5001233 · ExternalCitation · doi-reference
Nicotinic acetylcholine receptor-mediated calcium signaling in the nervous system
10.1038/aps.2009.64 · ExternalCitation · doi-reference
Ultrasensitive fluorescent proteins for imaging neuronal activity
10.1038/nature12354 · ExternalCitation · doi-reference
Retinoic acid in the development, regeneration and maintenance of the nervous system
10.1038/nrn2212 · ExternalCitation · doi-reference
Targeted P2X7/NLRP3 signaling pathway against inflammation, apoptosis, and pyroptosis of retinal endothelial cells in diabetic retinopathy
10.1038/s41419-022-04786-w · ExternalCitation · doi-reference
Late gene therapy limits the restoration of retinal function in a mouse model of retinitis pigmentosa
10.1038/s41467-023-44063-8 · ExternalCitation · doi-reference
Purinergic signalling
10.1038/sj.bjp.0706429 · ExternalCitation · doi-reference
Regulation of NMDA receptor Ca2+ signalling and synaptic plasticity
10.1042/bst0371369 · ExternalCitation · doi-reference
On the permeation of large organic cations through the pore of ATP-gated P2X receptors
10.1073/pnas.1701379114 · ExternalCitation · doi-reference
Calcium regulation of neuronal gene expression
10.1073/pnas.191352298 · ExternalCitation · doi-reference
P2X7/P2Z purinoreceptor-mediated activation of transcription factor NFAT in microglial cells
10.1074/jbc.274.19.13205 · ExternalCitation · doi-reference
Role of Purines in Muller Glia
10.1089/jop.2016.0131 · ExternalCitation · doi-reference
PROMO: detection of known transcription regulatory elements using species-tailored searches
10.1093/bioinformatics/18.2.333 · ExternalCitation · doi-reference
Identification of patterns in biological sequences at the ALGGEN server: PROMO and MALGEN
10.1093/nar/gkg605 · ExternalCitation · doi-reference
P2X7 receptor antagonism inhibits p38 mitogen-activated protein kinase activation and ameliorates neuronal apoptosis after subarachnoid hemorrhage in rats
10.1097/ccm.0b013e31829a8246 · ExternalCitation · doi-reference
Dopaminergic amacrine cells express HCN channels in the developing and adult mouse retina
10.1101/2024.07.20.604440 · ExternalCitation · doi-reference
Evidence for the involvement of purinergic P2X receptors in outer retinal processing
10.1111/j.1460-9568.2006.04895.x · ExternalCitation · doi-reference
Two separate Ni(2+) -sensitive voltage-gated Ca(2+) channels modulate transretinal signalling in the isolated murine retina
10.1111/j.1755-3768.2011.02167.x · ExternalCitation · doi-reference
Density-dependent changes of the pore properties of the P2X2 receptor channel
10.1113/jphysiol.2004.064568 · ExternalCitation · doi-reference
Retinoic acid inhibitors mitigate vision loss in a mouse model of retinal degeneration
10.1126/sciadv.abm4643 · ExternalCitation · doi-reference
Communication between the synapse and the nucleus in neuronal development, plasticity, and disease
10.1146/annurev.cellbio.24.110707.175235 · ExternalCitation · doi-reference
Intracellular calcium is regulated by different pathways in horizontal cells of the mouse retina
10.1152/jn.00191.2006 · ExternalCitation · doi-reference
Synaptic memory and CaMKII
10.1152/physrev.00034.2022 · ExternalCitation · doi-reference
RNA binding protein with multiple splicing: a new marker for retinal ganglion cells
10.1167/iovs.09-4098 · ExternalCitation · doi-reference
Thy1 associates with the cation channel subunit HCN4 in adult rat retina
10.1167/iovs.11-9307 · ExternalCitation · doi-reference
Local photoreceptor degeneration causes local pathophysiological remodeling of retinal neurons
10.1172/jci.insight.132114 · ExternalCitation · doi-reference
Genetics and functions of the retinoic acid pathway, with special emphasis on the eye
10.1186/s40246-019-0248-9 · ExternalCitation · doi-reference
Directional summation in non-direction selective retinal ganglion cells
10.1371/journal.pcbi.1002969 · ExternalCitation · doi-reference
Retinoic Acid-Dependent Loss of Synaptic Output from Bipolar Cells Impairs Visual Information Processing in Inherited Retinal Degeneration
10.1523/jneurosci.0129-24.2024 · ExternalCitation · doi-reference
Activation of a metabotropic glutamate receptor increases intracellular calcium concentrations in neurons of the avian cochlear nucleus
10.1523/jneurosci.15-01-00214.1995 · ExternalCitation · doi-reference
P2X7 receptors in Muller glial cells from the human retina
10.1523/jneurosci.20-16-05965.2000 · ExternalCitation · doi-reference
Contribution of calcium ions to P2X channel responses
10.1523/jneurosci.5429-03.2004 · ExternalCitation · doi-reference
The NMDA receptor complex: a multifunctional machine at the glutamatergic synapse
10.3389/fncel.2014.00160 · ExternalCitation · doi-reference
Clinical Impact of Spontaneous Hyperactivity in Degenerating Retinas: Significance for Diagnosis, Symptoms, and Treatment
10.3389/fncel.2018.00298 · ExternalCitation · doi-reference
Pleiotropic Roles of P2X7 in the Central Nervous System
10.3389/fncel.2019.00401 · ExternalCitation · doi-reference
Degeneration-Dependent Retinal Remodeling: Looking for the Molecular Trigger
10.3389/fnins.2020.618019 · ExternalCitation · doi-reference
Purinergic signaling via P2X receptors and mechanisms of unregulated ATP release in the outer retina and age-related macular degeneration
10.3389/fnins.2023.1216489 · ExternalCitation · doi-reference
Non-canonical retinoid signaling in neural development, regeneration and synaptic function
10.3389/fnmol.2024.1371135 · ExternalCitation · doi-reference
Unlocking the therapeutic potential of P2X7 receptor: a comprehensive review of its role in neurodegenerative disorders
10.3389/fphar.2024.1450704 · ExternalCitation · doi-reference
Structural MRI Differences between Patients with and without First Rank Symptoms: A Delusion?
10.3389/fpsyt.2015.00107 · ExternalCitation · doi-reference
P2X7 Is Involved in the Mouse Retinal Degeneration via the Coordinated Actions in Different Retinal Cell Types
10.3390/antiox12010141 · ExternalCitation · doi-reference
Differential Distribution of RBPMS in Pig, Rat, and Human Retina after Damage
10.3390/ijms21239330 · ExternalCitation · doi-reference
Purinergic Receptors P2X7 and P2X4 as Markers of Disease Progression in the rd10 Mouse Model of Inherited Retinal Dystrophy
10.3390/ijms232314758 · ExternalCitation · doi-reference
P2X7 receptor antagonist protects retinal ganglion cells by inhibiting microglial activation in a rat chronic ocular hypertension model
10.3892/mmr.2017.8137 · ExternalCitation · doi-reference
Non-canonical activity of retinoic acid in epigenetic control of embryonic stem cell
10.4161/trns.25395 · ExternalCitation · doi-reference
Metabotropic glutamate receptor dependent long-term depression in the cortex
10.4196/kjpp.2016.20.6.557 · ExternalCitation · doi-reference
