Research graph
References from Pulsed Low-Dose-Rate Radiotherapy (PLDR): A Comprehensive Review of Radiobiological Rationale and Clinical Applications in Modern Cancer Care. Local targets link to admitted publications; unresolved targets remain external evidence.
Pulsed low-dose rate radiotherapy has an improved therapeutic effect on abdominal and pelvic malignancies
10.1631/jzus.b2000793 · 2021 · External reference
Pulsed low-dose rate radiotherapy for recurrent bone sarcomas: case reports and brief review
10.3857/roj.2023.00815 · 2024 · External reference
Pulsed reduced dose-rate radiotherapy: a novel locoregional retreatment strategy for breast cancer recurrence in the previously irradiated chest wall, axilla, or supraclavicular region
10.1007/s10549-008-9995-3 · 2009 · External reference
Reirradiation of large-volume recurrent glioma with pulsed reduced-dose-rate radiotherapy
10.1016/j.ijrobp.2009.11.058 · 2011 · External reference
On the possible increase in local tumour control probability for gliomas exhibiting low dose hyper-radiosensitivity using a pulsed schedule
10.1259/bjr/15764945 · 2007 · External reference
Loss of biological effect in prolonged fraction delivery
10.1016/j.ijrobp.2004.01.004 · 2004 · External reference
Investigation of normal tissue toxicity in pulsed low dose rate radiotherapy
10.3390/cancers17101701 · 2025 · External reference
The diverse and complex roles of radiation on cancer treatment: therapeutic target and genome maintenance
2012 · External reference
Outcomes from whole-brain reirradiation using pulsed reduced dose rate radiation therapy
10.1016/j.adro.2020.06.021 · 2020 · External reference
Large volume re-irradiation for recurrent meningioma with pulsed reduced dose rate radiotherapy
10.1007/s11060-018-03011-z · 2019 · External reference
Dose rate in external beam radiotherapy for prostate cancer: an overlooked confounding variable?
10.1016/s0090-4295(03)00375-3 · 2003 · External reference
Tissue TGF-β expression following conventional radiotherapy and pulsed low-dose-rate radiation
10.1080/15384101.2017.1317418 · 2017 · External reference
Pulsed low dose-rate radiotherapy: radiobiology and dosimetry
10.1088/1361-6560/ac4c2f · 2022 · External reference
Pulsed reduced dose rate radiotherapy: a narrative review
10.21037/cco-24-115 · 2025 · External reference
Pulsed low dose-rate irradiation response in isogenic HNSCC cell lines with different radiosensitivity
10.2478/raon-2020-0015 · 2020 · External reference
Datasets of in vitro clonogenic assays showing low dose hyper-radiosensitivity and induced radioresistance
10.1038/s41597-022-01653-3 · 2022 · External reference
In vivo study of the radioadaptive response and low-dose hyper-radiosensitivity for chromosome breaks induced by gamma rays in wild-type Drosophila melanogaster larval neuroblasts: dose and dose rate dependence
10.1371/journal.pone.0325608 · 2025 · External reference
Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapy
10.20517/cdr.2020.89 · 2021 · External reference
DNA damage clustering after ionizing radiation and consequences in the processing of chromatin breaks
10.3390/molecules27051540 · 2022 · External reference
Cellular response to pulsed low-dose rate irradiation in X-ray sensitive hamster mutant cell lines
10.1269/jrr.45.385 · 2004 · External reference
Endothelial cell death after ionizing radiation does not impair vascular structure in mouse tumor models
10.15252/embr.202153221 · 2022 · External reference
Pulsed low-dose irradiation of orthotopic glioblastoma multiforme (GBM) in a pre-clinical model: effects on vascularization and tumor control
10.1016/j.radonc.2013.05.022 · 2013 · External reference
Toxicity assessment following conventional radiation therapy and pulsed low dose rate radiation therapy: an in vivo animal study
10.1186/s13014-024-02545-z · 2024 · External reference
A novel fast strategy to calculate equieffective doses under different dose rate conditions
10.1002/mp.17688 · 2025 · External reference
Investigation of dose-rate effects in pulsed low dose rate radiotherapy
10.30654/mjcs.10033 · 2022 · External reference
AAPM task group report 267: a joint AAPM GEC-ESTRO report on biophysical models and tools for the planning and evaluation of brachytherapy
10.1002/mp.17062 · 2024 · External reference
Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus
10.1158/1541-7786.mcr-05-0074 · 2005 · External reference
53BP1/RIF1 signaling promotes cell survival after multifractionated radiotherapy
10.1093/nar/gkz1139 · 2020 · External reference
Pulsed low-dose-rate external beam radiation therapy: an in-vivo study on prostate cancer
10.1016/j.ijrobp.2014.05.2276 · 2014 · External reference
Pulsed low dose rate radiation therapy effects on hepatic tumor rat model
2025 · External reference
Pulsed versus conventional radiation therapy in combination with temozolomide in a murine orthotopic model of glioblastoma multiforme
10.1016/j.ijrobp.2013.04.034 · 2013 · External reference
A clinical study on pulsed low dose rate radiation therapy for recurrent cancers
10.30654/mjcs.10028 · 2021 · External reference
Safety and efficacy of pulsed low-dose rate radiotherapy for local recurrent esophageal squamous cell carcinoma after radiotherapy: study protocol for a prospective multi-center phase II trial
10.1097/md.0000000000016176 · 2019 · External reference
Rhythmic radiotherapy beats down TGF-β
10.1080/15384101.2017.1337970 · 2017 · External reference
Understanding the pluses of pulses
10.1080/15384101.2017.1337979 · 2017 · External reference
The response of Chinese hamster V79 cells to low radiation doses: evidence of enhanced sensitivity of the whole cell population
10.2307/3578255 · 1993 · External reference
Pelvic reirradiation utilizing pulsed low-dose rate radiation therapy
10.1097/coc.0000000000000741 · 2020 · External reference
Optimization strategies for pulsed low-dose-rate IMRT of recurrent lung and head and neck cancers
10.1120/jacmp.v15i3.4661 · 2014 · External reference
Investigation of pulsed IMRT and VMAT for re-irradiation treatments: dosimetric and delivery feasibilities
10.1088/0031-9155/58/22/8179 · 2013 · External reference
Efficacy and safety of PLDR-IMRT for the re-irradiation of recurrent NPC: a prospective, single-arm, multicenter trial
10.1111/cas.15759 · 2023 · External reference
Pulsed-reduced dose rate (PRDR) radiotherapy for recurrent primary central nervous system malignancies: dosimetric and clinical results
10.3390/cancers14122946 · 2022 · External reference
Investigation of pulsed low dose rate radiotherapy using dynamic arc delivery techniques
10.1088/0031-9155/57/14/4613 · 2012 · External reference
External beam pulsed low dose radiotherapy using volumetric modulated arc therapy: planning and delivery
10.1118/1.4769119 · 2013 · External reference
Treatment planning for pulsed reduced dose-rate radiotherapy in helical tomotherapy
10.1016/j.ijrobp.2010.05.055 · 2011 · External reference
Reirradiation of glioblastoma through the use of a reduced dose rate on a tomotherapy unit
10.1177/153303461000900409 · 2010 · External reference
Initial feasibility cohort of temporally modulated pulsed proton re-irradiation (TMPPR) for recurrent high-grade intracranial malignancies
10.1038/s41598-024-78370-x · 2024 · External reference
Dosimetric accuracy of low dose rate volumetric modulated arc therapy delivery in an Elekta Versa HD linear accelerator for pulsed low dose rate treatment of recurrent high-grade glioma using Monaco planning system: low dose rate VMAT-based PLDR in Elekta Linac
10.1002/acm2.70253 · 2025 · External reference
Pulsed reduced-dose rate re-irradiation for patients with recurrent grade 2 gliomas
10.1093/noajnl/vdae073 · 2024 · External reference
Pulsed reduced-dose rate re-irradiation with intensity modulated radiation therapy (IMRT) for recurrent primary central nervous system malignancies
10.1016/j.ijrobp.2021.07.1582 · 2021 · External reference
Pulsed reduced dose-rate radiotherapy for previously irradiated tumors in the brain and spine
10.25259/sni_589_2020 · 2021 · External reference
Pulsed radiation therapy for the treatment of newly diagnosed glioblastoma
10.1093/neuonc/noaa165 · 2021 · External reference
Dosimetric accuracy of low dose rate volumetric modulated arc therapy delivery in an Elekta Versa HD linear accelerator for pulsed low dose rate treatment of recurrent high-grade glioma using Monaco planning system: low dose rate VMAT-based PLDR in Elekta Linac
10.1002/acm2.70253 · ExternalCitation · doi-reference
AAPM task group report 267: a joint AAPM GEC-ESTRO report on biophysical models and tools for the planning and evaluation of brachytherapy
10.1002/mp.17062 · ExternalCitation · doi-reference
A novel fast strategy to calculate equieffective doses under different dose rate conditions
10.1002/mp.17688 · ExternalCitation · doi-reference
Pulsed reduced dose-rate radiotherapy: a novel locoregional retreatment strategy for breast cancer recurrence in the previously irradiated chest wall, axilla, or supraclavicular region
10.1007/s10549-008-9995-3 · ExternalCitation · doi-reference
Large volume re-irradiation for recurrent meningioma with pulsed reduced dose rate radiotherapy
10.1007/s11060-018-03011-z · ExternalCitation · doi-reference
Outcomes from whole-brain reirradiation using pulsed reduced dose rate radiation therapy
10.1016/j.adro.2020.06.021 · ExternalCitation · doi-reference
Loss of biological effect in prolonged fraction delivery
10.1016/j.ijrobp.2004.01.004 · ExternalCitation · doi-reference
Reirradiation of large-volume recurrent glioma with pulsed reduced-dose-rate radiotherapy
10.1016/j.ijrobp.2009.11.058 · ExternalCitation · doi-reference
Treatment planning for pulsed reduced dose-rate radiotherapy in helical tomotherapy
10.1016/j.ijrobp.2010.05.055 · ExternalCitation · doi-reference
Pulsed versus conventional radiation therapy in combination with temozolomide in a murine orthotopic model of glioblastoma multiforme
10.1016/j.ijrobp.2013.04.034 · ExternalCitation · doi-reference
Pulsed low-dose-rate external beam radiation therapy: an in-vivo study on prostate cancer
10.1016/j.ijrobp.2014.05.2276 · ExternalCitation · doi-reference
Pulsed reduced-dose rate re-irradiation with intensity modulated radiation therapy (IMRT) for recurrent primary central nervous system malignancies
10.1016/j.ijrobp.2021.07.1582 · ExternalCitation · doi-reference
Pulsed low-dose irradiation of orthotopic glioblastoma multiforme (GBM) in a pre-clinical model: effects on vascularization and tumor control
10.1016/j.radonc.2013.05.022 · ExternalCitation · doi-reference
Dose rate in external beam radiotherapy for prostate cancer: an overlooked confounding variable?
10.1016/s0090-4295(03)00375-3 · ExternalCitation · doi-reference
Datasets of in vitro clonogenic assays showing low dose hyper-radiosensitivity and induced radioresistance
10.1038/s41597-022-01653-3 · ExternalCitation · doi-reference
Initial feasibility cohort of temporally modulated pulsed proton re-irradiation (TMPPR) for recurrent high-grade intracranial malignancies
10.1038/s41598-024-78370-x · ExternalCitation · doi-reference
Tissue TGF-β expression following conventional radiotherapy and pulsed low-dose-rate radiation
10.1080/15384101.2017.1317418 · ExternalCitation · doi-reference
Rhythmic radiotherapy beats down TGF-β
10.1080/15384101.2017.1337970 · ExternalCitation · doi-reference
Understanding the pluses of pulses
10.1080/15384101.2017.1337979 · ExternalCitation · doi-reference
Investigation of pulsed low dose rate radiotherapy using dynamic arc delivery techniques
10.1088/0031-9155/57/14/4613 · ExternalCitation · doi-reference
Investigation of pulsed IMRT and VMAT for re-irradiation treatments: dosimetric and delivery feasibilities
10.1088/0031-9155/58/22/8179 · ExternalCitation · doi-reference
Pulsed low dose-rate radiotherapy: radiobiology and dosimetry
10.1088/1361-6560/ac4c2f · ExternalCitation · doi-reference
53BP1/RIF1 signaling promotes cell survival after multifractionated radiotherapy
10.1093/nar/gkz1139 · ExternalCitation · doi-reference
Pulsed radiation therapy for the treatment of newly diagnosed glioblastoma
10.1093/neuonc/noaa165 · ExternalCitation · doi-reference
Pulsed reduced-dose rate re-irradiation for patients with recurrent grade 2 gliomas
10.1093/noajnl/vdae073 · ExternalCitation · doi-reference
Pelvic reirradiation utilizing pulsed low-dose rate radiation therapy
10.1097/coc.0000000000000741 · ExternalCitation · doi-reference
Safety and efficacy of pulsed low-dose rate radiotherapy for local recurrent esophageal squamous cell carcinoma after radiotherapy: study protocol for a prospective multi-center phase II trial
10.1097/md.0000000000016176 · ExternalCitation · doi-reference
Efficacy and safety of PLDR-IMRT for the re-irradiation of recurrent NPC: a prospective, single-arm, multicenter trial
10.1111/cas.15759 · ExternalCitation · doi-reference
External beam pulsed low dose radiotherapy using volumetric modulated arc therapy: planning and delivery
10.1118/1.4769119 · ExternalCitation · doi-reference
Optimization strategies for pulsed low-dose-rate IMRT of recurrent lung and head and neck cancers
10.1120/jacmp.v15i3.4661 · ExternalCitation · doi-reference
Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus
10.1158/1541-7786.mcr-05-0074 · ExternalCitation · doi-reference
Reirradiation of glioblastoma through the use of a reduced dose rate on a tomotherapy unit
10.1177/153303461000900409 · ExternalCitation · doi-reference
Toxicity assessment following conventional radiation therapy and pulsed low dose rate radiation therapy: an in vivo animal study
10.1186/s13014-024-02545-z · ExternalCitation · doi-reference
On the possible increase in local tumour control probability for gliomas exhibiting low dose hyper-radiosensitivity using a pulsed schedule
10.1259/bjr/15764945 · ExternalCitation · doi-reference
Cellular response to pulsed low-dose rate irradiation in X-ray sensitive hamster mutant cell lines
10.1269/jrr.45.385 · ExternalCitation · doi-reference
In vivo study of the radioadaptive response and low-dose hyper-radiosensitivity for chromosome breaks induced by gamma rays in wild-type Drosophila melanogaster larval neuroblasts: dose and dose rate dependence
10.1371/journal.pone.0325608 · ExternalCitation · doi-reference
Endothelial cell death after ionizing radiation does not impair vascular structure in mouse tumor models
10.15252/embr.202153221 · ExternalCitation · doi-reference
Pulsed low-dose rate radiotherapy has an improved therapeutic effect on abdominal and pelvic malignancies
10.1631/jzus.b2000793 · ExternalCitation · doi-reference
Exploiting DNA repair pathways for tumor sensitization, mitigation of resistance, and normal tissue protection in radiotherapy
10.20517/cdr.2020.89 · ExternalCitation · doi-reference
Pulsed reduced dose rate radiotherapy: a narrative review
10.21037/cco-24-115 · ExternalCitation · doi-reference
The response of Chinese hamster V79 cells to low radiation doses: evidence of enhanced sensitivity of the whole cell population
10.2307/3578255 · ExternalCitation · doi-reference
Pulsed low dose-rate irradiation response in isogenic HNSCC cell lines with different radiosensitivity
10.2478/raon-2020-0015 · ExternalCitation · doi-reference
Pulsed reduced dose-rate radiotherapy for previously irradiated tumors in the brain and spine
10.25259/sni_589_2020 · ExternalCitation · doi-reference
A clinical study on pulsed low dose rate radiation therapy for recurrent cancers
10.30654/mjcs.10028 · ExternalCitation · doi-reference
Investigation of dose-rate effects in pulsed low dose rate radiotherapy
10.30654/mjcs.10033 · ExternalCitation · doi-reference
Pulsed-reduced dose rate (PRDR) radiotherapy for recurrent primary central nervous system malignancies: dosimetric and clinical results
10.3390/cancers14122946 · ExternalCitation · doi-reference
Investigation of normal tissue toxicity in pulsed low dose rate radiotherapy
10.3390/cancers17101701 · ExternalCitation · doi-reference
DNA damage clustering after ionizing radiation and consequences in the processing of chromatin breaks
10.3390/molecules27051540 · ExternalCitation · doi-reference
Pulsed low-dose rate radiotherapy for recurrent bone sarcomas: case reports and brief review
10.3857/roj.2023.00815 · ExternalCitation · doi-reference
