Research graph
References from Regenerative Medicine in the Management of Musculoskeletal Pain: Mechanisms, Clinical Applications, and Future Directions. Local targets link to admitted publications; unresolved targets remain external evidence.
Global estimates of the need for rehabilitation based on the Global Burden of Disease Study 2019: a systematic analysis for the Global Burden of Disease Study 2019
10.1016/s0140-6736(20)32340-0 · 2021 · External reference
Global Report on Health Equity for Persons With Disabilities
2023 · External reference
Management of musculoskeletal pain: an update with emphasis on chronic musculoskeletal pain
10.1007/s40122-021-00235-2 · 2021 · External reference
Mesenchymal stem cells as therapeutic target of biophysical stimulation for the treatment of musculoskeletal disorders
10.1186/s13018-016-0496-5 · 2016 · External reference
Choosing a nonsteroidal anti-inflammatory drug for pain
10.18773/austprescr.2025.032 · 2025 · External reference
Long-term use of opioids for complex chronic pain
10.1016/j.berh.2013.09.011 · 2013 · External reference
Regenerative medicine in pain control: a review
10.30574/wjarr.2025.25.3.0702 · 2025 · External reference
How does surgery compare to sham surgery or physiotherapy as a treatment for tendinopathy? A systematic review of randomised trials
10.1136/bmjsem-2019-000528 · 2019 · External reference
Osteoarthritis: pathology, diagnosis, and treatment options
10.1016/j.mcna.2019.10.007 · 2020 · External reference
The tiny giants of regeneration: MSC-derived extracellular vesicles as next-generation therapeutics
10.3389/fcell.2025.1612589 · 2025 · External reference
Effectiveness of combined regenerative medicine and exercise therapy for patients with knee osteoarthritis: a scoping review
10.3389/fresc.2025.1612615 · 2025 · External reference
Unresolved reference
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Unresolved reference
External reference
The clinical status of cartilage tissue regeneration in humans
10.1016/j.joca.2013.08.024 · 2013 · External reference
Considerations in modern regenerative medicine for osteoarthritis
10.1530/eor-2025-0050 · 2025 · External reference
Stem cells in regenerative medicine: a journey from adult stem cells to induced pluripotent cells
10.3390/ijms26178255 · 2025 · External reference
The efficacy of platelet-rich plasma preparation protocols in the treatment of osteoarthritis: a network meta-analysis of randomized controlled trials
10.1186/s13018-025-06026-1 · 2025 · External reference
Effectiveness of platelet-rich plasma in treating rotator cuff tendinopathy: a systematic review and meta-analysis
10.13107/jocr.2025.v15.i03.5408 · 2025 · External reference
Immunomodulatory biomaterials for osteoarthritis: targeting inflammation and enhancing cartilage regeneration
10.1016/j.mtbio.2025.102100 · 2025 · External reference
Unresolved reference
External reference
Unresolved reference
External reference
Extracellular vesicles in musculoskeletal regeneration: modulating the therapy of the future
10.3390/cells11010043 · 2021 · External reference
Unresolved reference
External reference
Principles and methods of preparation of platelet-rich plasma: a review and author's perspective
10.4103/0974-2077.150734 · 2014 · External reference
A cross-sectional analysis of the effects of various centrifugation speeds and inclusion of the buffy coat in platelet-rich plasma preparation
10.25259/ijdvl_1050_20 · 2021 · External reference
Comparative efficacy of intra-articular platelet-rich plasma, hyaluronic acid, corticosteroids, and NSAIDs for knee osteoarthritis: a retrospective cohort study
10.1097/md.0000000000044929 · 2025 · External reference
Meta-analysis comparing platelet-rich plasma vs hyaluronic acid injection in patients with knee osteoarthritis
10.1093/pm/pnz011 · 2019 · External reference
Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis of 26 randomized controlled trials
10.1016/j.arthro.2020.07.011 · 2021 · External reference
The efficacy of platelet-rich plasma injections compared to corticosteroids and physiotherapy in adhesive capsulitis: a systematic review and meta-analysis
10.1016/j.jor.2023.10.015 · 2024 · External reference
Mesenchymal stem cells in treating human diseases: molecular mechanisms and clinical studies
10.1038/s41392-025-02313-9 · 2025 · External reference
Hypertonic dextrose prolotherapy in osteoarthritis: mechanisms, efficacy, and future research directions
10.3389/fendo.2025.1602727 · 2025 · External reference
Platelet-poor plasma for muscle injuries: a review of mechanisms and clinical perspectives
10.1177/23259671251356628 · 2025 · External reference
Efficacy and safety of platelet-rich plasma injections for the treatment of knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials
10.1186/s40001-025-03253-4 · 2025 · External reference
Comprehensive evidence-based guidelines for regenerative therapies in the management of chronic low back pain: 2025 update from the American Society of Interventional Pain Physicians (ASIPP)
2025 · External reference
Use of platelet-rich plasma for the improvement of pain and function in rotator cuff tears: a systematic review and meta-analysis with bias assessment
10.1177/0363546519881423 · 2020 · External reference
US definitions, current use, and FDA stance on use of platelet-rich plasma in sports medicine
10.1055/s-0034-1390030 · 2015 · External reference
Indications and contraindications to platelet-rich plasma injections in musculoskeletal diseases in case of infectious, oncological and haematological comorbidities: a 2025 formal consensus from the GRIIP (International Research Group on Platelet Injections)
10.1002/ksa.12682 · 2025 · External reference
Profound properties of protein-rich, platelet-rich plasma matrices as novel, multi-purpose biological platforms in tissue repair, regeneration, and wound healing
10.3390/ijms25147914 · 2024 · External reference
Expressions of growth factors in autologous derived platelet-rich plasma and platelet-poor plasma; implication for tissue reparation and wound healing
10.26717/bjstr.2019.18.003191 · 2019 · External reference
Protocol for obtaining platelet-rich plasma (PRP), platelet-poor plasma (PPP), and thrombin for autologous use
10.1007/s00266-012-9957-3 · 2012 · External reference
Current advances in the treatment of myofascial pain syndrome with trigger point injections: a review
10.1097/md.0000000000039885 · 2024 · External reference
Platelet-poor versus platelet-rich plasma for the treatment of muscle injuries
10.1249/jsr.0000000000001173 · 2024 · External reference
Platelet-rich plasma does not enhance return to play in hamstring injuries: a randomised controlled trial
10.1136/bjsports-2015-094603 · 2015 · External reference
Chapter 1 - Autologous blood: platelet-rich plasma and platelet-poor plasma
10.1016/b978-0-12-822902-6.00018-0 · 2025 · External reference
Leukocyte-poor platelet-rich plasma as an adjuvant to arthroscopic rotator cuff repair reduces the retear rate but does not improve functional outcomes: a double-blind randomized controlled trial
10.1177/03635465241239062 · 2024 · External reference
Mesenchymal stem cells injections in traumatology and orthopaedics: Common practice or still a promising area with many uncertainties?
10.1186/s12891-025-09123-8 · 2025 · External reference
Human mesenchymal stem cells - current trends and future prospective
10.1042/bsr20150025 · 2015 · External reference
Role of mesenchymal stem cells in bone regenerative medicine: What is the evidence?
10.1159/000469704 · 2017 · External reference
Oral bone tissue regeneration: mesenchymal stem cells, secretome, and biomaterials
10.3390/ijms22105236 · 2021 · External reference
Recent advance in source, property, differentiation, and applications of infrapatellar fat pad adipose-derived stem cells
10.1155/2020/2560174 · 2020 · External reference
Genetically engineered-MSC therapies for non-unions, delayed unions and critical-size bone defects
10.3390/ijms20143430 · 2019 · External reference
Systemic mesenchymal stem cell administration enhances bone formation in fracture repair but not load-induced bone formation
10.22203/ecm.v029a02 · 2015 · External reference
Mesenchymal stem cell secretome for regenerative medicine: Where do we stand?
10.1016/j.jare.2024.05.004 · 2025 · External reference
Human umbilical cord-derived mesenchymal stem cell therapy ameliorates lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis
10.7150/thno.48080 · 2021 · External reference
Mesenchymal stem cells derived extracellular vesicles: a promising nanomedicine for drug delivery system
10.1016/j.bcp.2022.115167 · 2022 · External reference
An update on adipose-derived stem cells for regenerative medicine: where challenge meets opportunity
10.1002/advs.202207334 · 2023 · External reference
Microfragmented adipose tissue in pain management: bridging regenerative biology and clinical therapeutics
10.1007/s40122-026-00877-0 · 2026 · External reference
Adipose tissue and mesenchymal stem cells: state of the art and Lipogems® technology development
10.1007/s40778-016-0053-5 · 2016 · External reference
Higher pericyte content and secretory activity of microfragmented human adipose tissue compared to enzymatically derived stromal vascular fraction
10.1002/sctm.18-0051 · 2018 · External reference
A scoping review on mechanically micronized adipose-derived products: technological innovations and regenerative potential
10.1093/asj/sjag025 · 2026 · External reference
Adipose tissue-derived mesenchymal stem/stromal cells and their contribution to angiogenic processes in tissue regeneration
10.3390/ijms23052425 · 2022 · External reference
The paradigm of stem cell secretome in tissue repair and regeneration: present and future perspectives
10.1111/wrr.13251 · 2025 · External reference
Arthroscopic debridement followed by intra-articular injection of micro-fragmented adipose tissue in patients affected by knee osteoarthritis: clinical results up to 48 months from a prospective clinical study
10.1002/jeo2.70144 · 2025 · External reference
Microfragmented adipose tissue versus platelet-rich plasma in the treatment of knee osteoarthritis: a systematic review and meta-analysis
10.52628/90.3.12669 · 2024 · External reference
Micro-fragmented stromal-vascular fraction plus microfractures provides better clinical results than microfractures alone in symptomatic focal chondral lesions of the knee
10.1007/s00167-019-05621-0 · 2020 · External reference
Arthroscopic rotator cuff repair augmentation with autologous microfragmented lipoaspirate tissue is safe and effectively improves short-term clinical and functional results: a prospective randomized controlled trial with 24-month follow-up
10.1177/03635465221083324 · 2022 · External reference
Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study
10.1186/s13287-017-0710-3 · 2017 · External reference
Human umbilical mesenchymal stem cells display therapeutic potential in rheumatoid arthritis by regulating interactions between immunity and gut microbiota via the aryl hydrocarbon receptor
10.3389/fcell.2020.00131 · 2020 · External reference
Advancing osteoarthritis treatment: the therapeutic potential of mesenchymal stem cell-derived exosomes and biomaterial integration
10.3390/biomedicines12112478 · 2024 · External reference
Mesenchymal stem cell-derived extracellular vesicles: opportunities and challenges for clinical translation
10.3389/fbioe.2020.00997 · 2020 · External reference
Exosomes: small vesicles participating in intercellular communication
10.1016/j.biocel.2011.10.005 · 2012 · External reference
Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles
10.1146/annurev-cellbio-101512-122326 · 2014 · External reference
Shedding light on the cell biology of extracellular vesicles
10.1038/nrm.2017.125 · 2018 · External reference
Chicken-or-egg question: Which came first, extracellular vesicles or autoimmune diseases?
10.1002/jlb.3mr0120-232r · 2020 · External reference
Mesenchymal stem cell-derived extracellular vesicles in musculoskeletal regeneration: mechanisms, applications, and future prospects
10.1186/s13287-025-04879-1 · 2026 · External reference
The role of extracellular vesicles in musculoskeletal diseases
10.1002/jev2.70205 · 2025 · External reference
Mesenchymal stem cell-derived extracellular vesicles in bone-related diseases: intercellular communication messengers and therapeutic engineering protagonists
10.2147/ijn.s441467 · 2024 · External reference
Harnessing stem cell-derived extracellular vesicles for the regeneration of degenerative bone conditions
10.2147/ijn.s424731 · 2023 · External reference
MSC-EVs alleviate osteoarthritis by regulating microenvironmental cells in the articular cavity and maintaining cartilage matrix homeostasis
10.1016/j.arr.2023.101864 · 2023 · External reference
Mesenchymal stem cell-derived extracellular vesicles in joint diseases: therapeutic effects and underlying mechanisms
10.1016/j.jot.2024.07.005 · 2024 · External reference
Stem cells and exosomes: new therapies for intervertebral disc degeneration
10.3390/cells10092241 · 2021 · External reference
Functional role of extracellular vesicles in skeletal muscle physiology and sarcopenia: the importance of physical exercise and nutrition
10.3390/nu16183097 · 2024 · External reference
Intervertebral disc tissue engineering: a brief review
10.17305/bjbms.2019.3778 · 2019 · External reference
Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages
10.1186/s12951-023-02075-y · 2023 · External reference
Trends in mesenchymal stem cell-derived extracellular vesicles clinical trials 2014-2024: Is efficacy optimal in a narrow dose range?
10.3389/fmed.2025.1625787 · 2025 · External reference
Mesenchymal stromal cell-based products: challenges and clinical therapeutic options
10.3390/ijms25116063 · 2024 · External reference
Unresolved reference
External reference
Challenges and future perspectives in using mesenchymal stem cells for efficient bone fracture healing
10.3389/fbioe.2025.1568914 · 2025 · External reference
The biology, function, and biomedical applications of exosomes
10.1126/science.aau6977 · 2020 · External reference
Exosome: a review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications
10.2147/ijn.s264498 · 2020 · External reference
Current knowledge on exosome biogenesis and release
10.1007/s00018-017-2595-9 · 2018 · External reference
Late endosome motility depends on lipids via the small GTPase Rab7
10.1093/emboj/21.6.1289 · 2002 · External reference
Regulation of exosomes as biologic medicines: regulatory challenges faced in exosome development and manufacturing processes
10.1111/cts.13904 · 2024 · External reference
Mesenchymal stem cell-derived extracellular vesicles: challenges in clinical applications
10.3389/fcell.2020.00149 · 2020 · External reference
MiRNA-sequence indicates that mesenchymal stem cells and exosomes have similar mechanism to enhance cardiac repair
10.1155/2017/4150705 · 2017 · External reference
Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model
10.1007/s00109-013-1110-5 · 2014 · External reference
Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension
10.1161/circulationaha.112.114173 · 2012 · External reference
Mesenchymal stem cell exosomes induce proliferation and migration of normal and chronic wound fibroblasts, and enhance angiogenesis in vitro
10.1089/scd.2014.0316 · 2015 · External reference
Exosomes released from human induced pluripotent stem cells-derived MSCs facilitate cutaneous wound healing by promoting collagen synthesis and angiogenesis
10.1186/s12967-015-0417-0 · 2015 · External reference
Extracellular vesicles: evolving factors in stem cell biology
10.1155/2016/1073140 · 2016 · External reference
Mesenchymal stem cell-derived exosomes: toward cell-free therapeutic strategies in regenerative medicine
10.4252/wjsc.v12.i8.814 · 2020 · External reference
Harnessing the potential of mesenchymal stem cells-derived exosomes in degenerative diseases
10.1016/j.reth.2024.08.001 · 2024 · External reference
Immunomodulatory and regenerative functions of MSC-derived exosomes in bone repair
10.3390/bioengineering12080844 · 2025 · External reference
The potential of exosomes in regenerative medicine and in the diagnosis and therapies of neurodegenerative diseases and cancer
10.3389/fmed.2025.1539714 · 2025 · External reference
Gene therapy approaches to regenerating the musculoskeletal system
10.1038/nrrheum.2015.28 · 2015 · External reference
Engineering inflammation-resistant cartilage: bridging gene therapy and tissue engineering
10.1002/adhm.202202271 · 2023 · External reference
Cell and gene therapy products: navigating the regulatory landscape of paradigm approvals in the US (2020 to 2024)
10.1007/s12247-025-09973-8 · 2025 · External reference
Gene therapy for regenerative medicine
10.3390/pharmaceutics15030856 · 2023 · External reference
Biomaterial-based scaffolds in promotion of cartilage regeneration: recent advances and emerging applications
10.1016/j.jot.2023.08.006 · 2023 · External reference
New insights into cartilage tissue engineering: improvement of tissue-scaffold integration to enhance cartilage regeneration
10.1155/2022/7638245 · 2022 · External reference
Recent advancements in cartilage tissue engineering innovation and translation
10.1038/s41584-024-01118-4 · 2024 · External reference
Tissue engineering and future directions in regenerative medicine for knee cartilage repair: a comprehensive review
10.3325/cmj.2024.65.268 · 2024 · External reference
Prolotherapy in the treatment of sports-related tendinopathies: a systematic review of randomized controlled trials
10.1177/23259671241275087 · 2024 · External reference
Recent advances in biomaterials for 3D scaffolds: a review
10.1016/j.bioactmat.2019.10.005 · 2019 · External reference
Cartilage tissue engineering: from biomaterials and stem cells to osteoarthritis treatments
10.1016/j.rehab.2016.03.002 · 2016 · External reference
Gene- and RNAi-activated scaffolds for bone tissue engineering: current progress and future directions
10.1016/j.addr.2021.05.009 · 2021 · External reference
Porous biomaterial scaffolds for skeletal muscle tissue engineering
10.3389/fbioe.2023.1245897 · 2023 · External reference
Integrating gene delivery and gene-editing technologies by adenoviral vector transfer of optimized CRISPR-Cas9 components
10.1038/s41434-019-0119-y · 2020 · External reference
Biofabrication methods for reconstructing extracellular matrix mimetics
10.1016/j.bioactmat.2023.08.018 · 2024 · External reference
Exploration of CRISPR/Cas9-based gene editing as therapy for osteoarthritis
10.1136/annrheumdis-2018-214724 · 2019 · External reference
Comparative effectiveness of platelet rich plasma PRP stem cells and exosomes in the treatment of sports injuries a narrative review
10.35630/2026/16/iss.1.016 · 2026 · External reference
Comparing regenerative biologics and standard pharmacotherapy for chronic rotator cuff tendinopathy: a study of PRP, cell-based, and peptide interventions
10.26502/josm.511500247 · 2026 · External reference
Dual-action regenerative therapies: regeneration and antimicrobial effects of platelet- and marrow-derived biologics
10.3390/biomedicines13112832 · 2025 · External reference
Clinical applications of extracellular vesicles: promises and pitfalls
10.3390/ijms27031509 · 2026 · External reference
Applications of bone regenerative medicine in the foot and ankle: mechanisms, technologies, and therapeutic advances
10.3389/fbioe.2025.1653964 · 2025 · External reference
Editorial: Recent advancements in musculoskeletal regenerative medicine
10.3389/fcell.2025.1688419 · 2025 · External reference
Artificial intelligence (AI): a potential game changer in regenerative orthopedics—a scoping review
10.1007/s43465-024-01189-1 · 2024 · External reference
Advancing osteoarthritis research: the role of AI in clinical, imaging and omics fields
10.1038/s41413-025-00423-2 · 2025 · External reference
Emerging diagnostic approaches for musculoskeletal disorders: advances in imaging, biomarkers, and clinical assessment
10.3390/diagnostics15131648 · 2025 · External reference
Incorporation of "artificial intelligence" for objective pain assessment: a comprehensive review
10.1007/s40122-024-00584-8 · 2024 · External reference
The application of artificial intelligence (AI) in regenerative medicine: current insights and challenges
10.3390/biomedinformatics5040069 · 2025 · External reference
Mesenchymal stromal cell-derived extracellular vesicles in regenerative medicine: standardisation, bioengineering and clinical translation
10.1016/j.reth.2025.101058 · 2026 · External reference
Therapeutic strategy for exosome-based bone regeneration to osteoporosis: challenges and potential solutions
10.1016/j.jare.2025.09.042 · 2026 · External reference
Advances in extracellular vesicle-based nanomedicine for regenerative orthopaedics
10.1186/s12951-025-03906-w · 2025 · External reference
3D bioprinted scaffolds for osteochondral regeneration: advancements and applications
10.1016/j.mtbio.2025.101834 · 2025 · External reference
Advances in 3D bioprinting for regenerative medicine applications
10.1093/rb/rbae033 · 2024 · External reference
Insight into the functional dynamics and challenges of exosomes in pharmaceutical innovation and precision medicine
10.3390/pharmaceutics16060709 · 2024 · External reference
PRP, exosomes, and stem cells: an international perspective
10.1002/der2.70000 · 2024 · External reference
Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches
10.1002/jev2.12404 · 2024 · External reference
Computational and imaging approaches for precision characterization of bone, cartilage, and synovial biomolecules
10.3390/jpm15070298 · 2025 · External reference
Regenerative engineering AI: a new paradigm for the future of tissue regeneration
10.1007/s11705-025-2566-x · 2025 · External reference
Engineering inflammation-resistant cartilage: bridging gene therapy and tissue engineering
10.1002/adhm.202202271 · ExternalCitation · doi-reference
An update on adipose-derived stem cells for regenerative medicine: where challenge meets opportunity
10.1002/advs.202207334 · ExternalCitation · doi-reference
PRP, exosomes, and stem cells: an international perspective
10.1002/der2.70000 · ExternalCitation · doi-reference
Arthroscopic debridement followed by intra-articular injection of micro-fragmented adipose tissue in patients affected by knee osteoarthritis: clinical results up to 48 months from a prospective clinical study
10.1002/jeo2.70144 · ExternalCitation · doi-reference
Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches
10.1002/jev2.12404 · ExternalCitation · doi-reference
The role of extracellular vesicles in musculoskeletal diseases
10.1002/jev2.70205 · ExternalCitation · doi-reference
Chicken-or-egg question: Which came first, extracellular vesicles or autoimmune diseases?
10.1002/jlb.3mr0120-232r · ExternalCitation · doi-reference
Indications and contraindications to platelet-rich plasma injections in musculoskeletal diseases in case of infectious, oncological and haematological comorbidities: a 2025 formal consensus from the GRIIP (International Research Group on Platelet Injections)
10.1002/ksa.12682 · ExternalCitation · doi-reference
Higher pericyte content and secretory activity of microfragmented human adipose tissue compared to enzymatically derived stromal vascular fraction
10.1002/sctm.18-0051 · ExternalCitation · doi-reference
Current knowledge on exosome biogenesis and release
10.1007/s00018-017-2595-9 · ExternalCitation · doi-reference
Extracellular vesicles derived from human bone marrow mesenchymal stem cells promote angiogenesis in a rat myocardial infarction model
10.1007/s00109-013-1110-5 · ExternalCitation · doi-reference
Micro-fragmented stromal-vascular fraction plus microfractures provides better clinical results than microfractures alone in symptomatic focal chondral lesions of the knee
10.1007/s00167-019-05621-0 · ExternalCitation · doi-reference
Protocol for obtaining platelet-rich plasma (PRP), platelet-poor plasma (PPP), and thrombin for autologous use
10.1007/s00266-012-9957-3 · ExternalCitation · doi-reference
Regenerative engineering AI: a new paradigm for the future of tissue regeneration
10.1007/s11705-025-2566-x · ExternalCitation · doi-reference
Cell and gene therapy products: navigating the regulatory landscape of paradigm approvals in the US (2020 to 2024)
10.1007/s12247-025-09973-8 · ExternalCitation · doi-reference
Management of musculoskeletal pain: an update with emphasis on chronic musculoskeletal pain
10.1007/s40122-021-00235-2 · ExternalCitation · doi-reference
Incorporation of "artificial intelligence" for objective pain assessment: a comprehensive review
10.1007/s40122-024-00584-8 · ExternalCitation · doi-reference
Microfragmented adipose tissue in pain management: bridging regenerative biology and clinical therapeutics
10.1007/s40122-026-00877-0 · ExternalCitation · doi-reference
Adipose tissue and mesenchymal stem cells: state of the art and Lipogems® technology development
10.1007/s40778-016-0053-5 · ExternalCitation · doi-reference
Artificial intelligence (AI): a potential game changer in regenerative orthopedics—a scoping review
10.1007/s43465-024-01189-1 · ExternalCitation · doi-reference
Chapter 1 - Autologous blood: platelet-rich plasma and platelet-poor plasma
10.1016/b978-0-12-822902-6.00018-0 · ExternalCitation · doi-reference
Gene- and RNAi-activated scaffolds for bone tissue engineering: current progress and future directions
10.1016/j.addr.2021.05.009 · ExternalCitation · doi-reference
MSC-EVs alleviate osteoarthritis by regulating microenvironmental cells in the articular cavity and maintaining cartilage matrix homeostasis
10.1016/j.arr.2023.101864 · ExternalCitation · doi-reference
Platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis of 26 randomized controlled trials
10.1016/j.arthro.2020.07.011 · ExternalCitation · doi-reference
Mesenchymal stem cells derived extracellular vesicles: a promising nanomedicine for drug delivery system
10.1016/j.bcp.2022.115167 · ExternalCitation · doi-reference
Long-term use of opioids for complex chronic pain
10.1016/j.berh.2013.09.011 · ExternalCitation · doi-reference
Recent advances in biomaterials for 3D scaffolds: a review
10.1016/j.bioactmat.2019.10.005 · ExternalCitation · doi-reference
Biofabrication methods for reconstructing extracellular matrix mimetics
10.1016/j.bioactmat.2023.08.018 · ExternalCitation · doi-reference
Exosomes: small vesicles participating in intercellular communication
10.1016/j.biocel.2011.10.005 · ExternalCitation · doi-reference
Mesenchymal stem cell secretome for regenerative medicine: Where do we stand?
10.1016/j.jare.2024.05.004 · ExternalCitation · doi-reference
Therapeutic strategy for exosome-based bone regeneration to osteoporosis: challenges and potential solutions
10.1016/j.jare.2025.09.042 · ExternalCitation · doi-reference
The clinical status of cartilage tissue regeneration in humans
10.1016/j.joca.2013.08.024 · ExternalCitation · doi-reference
The efficacy of platelet-rich plasma injections compared to corticosteroids and physiotherapy in adhesive capsulitis: a systematic review and meta-analysis
10.1016/j.jor.2023.10.015 · ExternalCitation · doi-reference
Biomaterial-based scaffolds in promotion of cartilage regeneration: recent advances and emerging applications
10.1016/j.jot.2023.08.006 · ExternalCitation · doi-reference
Mesenchymal stem cell-derived extracellular vesicles in joint diseases: therapeutic effects and underlying mechanisms
10.1016/j.jot.2024.07.005 · ExternalCitation · doi-reference
Osteoarthritis: pathology, diagnosis, and treatment options
10.1016/j.mcna.2019.10.007 · ExternalCitation · doi-reference
3D bioprinted scaffolds for osteochondral regeneration: advancements and applications
10.1016/j.mtbio.2025.101834 · ExternalCitation · doi-reference
Immunomodulatory biomaterials for osteoarthritis: targeting inflammation and enhancing cartilage regeneration
10.1016/j.mtbio.2025.102100 · ExternalCitation · doi-reference
Cartilage tissue engineering: from biomaterials and stem cells to osteoarthritis treatments
10.1016/j.rehab.2016.03.002 · ExternalCitation · doi-reference
Harnessing the potential of mesenchymal stem cells-derived exosomes in degenerative diseases
10.1016/j.reth.2024.08.001 · ExternalCitation · doi-reference
Mesenchymal stromal cell-derived extracellular vesicles in regenerative medicine: standardisation, bioengineering and clinical translation
10.1016/j.reth.2025.101058 · ExternalCitation · doi-reference
Global estimates of the need for rehabilitation based on the Global Burden of Disease Study 2019: a systematic analysis for the Global Burden of Disease Study 2019
10.1016/s0140-6736(20)32340-0 · ExternalCitation · doi-reference
Shedding light on the cell biology of extracellular vesicles
10.1038/nrm.2017.125 · ExternalCitation · doi-reference
Gene therapy approaches to regenerating the musculoskeletal system
10.1038/nrrheum.2015.28 · ExternalCitation · doi-reference
Mesenchymal stem cells in treating human diseases: molecular mechanisms and clinical studies
10.1038/s41392-025-02313-9 · ExternalCitation · doi-reference
Advancing osteoarthritis research: the role of AI in clinical, imaging and omics fields
10.1038/s41413-025-00423-2 · ExternalCitation · doi-reference
Integrating gene delivery and gene-editing technologies by adenoviral vector transfer of optimized CRISPR-Cas9 components
10.1038/s41434-019-0119-y · ExternalCitation · doi-reference
Recent advancements in cartilage tissue engineering innovation and translation
10.1038/s41584-024-01118-4 · ExternalCitation · doi-reference
Human mesenchymal stem cells - current trends and future prospective
10.1042/bsr20150025 · ExternalCitation · doi-reference
US definitions, current use, and FDA stance on use of platelet-rich plasma in sports medicine
10.1055/s-0034-1390030 · ExternalCitation · doi-reference
Mesenchymal stem cell exosomes induce proliferation and migration of normal and chronic wound fibroblasts, and enhance angiogenesis in vitro
10.1089/scd.2014.0316 · ExternalCitation · doi-reference
A scoping review on mechanically micronized adipose-derived products: technological innovations and regenerative potential
10.1093/asj/sjag025 · ExternalCitation · doi-reference
Late endosome motility depends on lipids via the small GTPase Rab7
10.1093/emboj/21.6.1289 · ExternalCitation · doi-reference
Meta-analysis comparing platelet-rich plasma vs hyaluronic acid injection in patients with knee osteoarthritis
10.1093/pm/pnz011 · ExternalCitation · doi-reference
Advances in 3D bioprinting for regenerative medicine applications
10.1093/rb/rbae033 · ExternalCitation · doi-reference
Current advances in the treatment of myofascial pain syndrome with trigger point injections: a review
10.1097/md.0000000000039885 · ExternalCitation · doi-reference
Comparative efficacy of intra-articular platelet-rich plasma, hyaluronic acid, corticosteroids, and NSAIDs for knee osteoarthritis: a retrospective cohort study
10.1097/md.0000000000044929 · ExternalCitation · doi-reference
Regulation of exosomes as biologic medicines: regulatory challenges faced in exosome development and manufacturing processes
10.1111/cts.13904 · ExternalCitation · doi-reference
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