Research graph
References from Thermodynamic Basis of Paton’s Rate Theory of Drug Action: Occupation Theory as Its Steady-State Limit. Local targets link to admitted publications; unresolved targets remain external evidence.
The principles of drug action
10.1177/003591576005301002 · 1960 · External reference
A theory of drug action based on the rate of drug-receptor combination
10.1098/rspb.1961.0020 · 1961 · External reference
The uptake of atropine and related drugs by intestinal smooth muscle of the guinea-pig in relation to acetylcholine receptors
10.1098/rspb.1965.0058 · 1965 · External reference
Kinetic theories of drug action with special reference to the acetylcholine group of agonists and antagonists
10.1111/j.1749-6632.1967.tb53816.x · 1967 · External reference
Affinity and intrinsic activity in the theory of competitive inhibition. I. Problems and theory
1954 · External reference
The reaction between acetyl choline and muscle cells
10.1113/jphysiol.1926.sp002314 · 1926 · External reference
Theories of drug antagonism
10.1016/s0031-6997(25)07217-5 · 1957 · External reference
Use of the biological stimulus in determining parameters of drug action, and its relationship to the drug effect: a contribution to the theory of drug action
10.1016/0022-5193(77)90135-7 · 1977 · External reference
Biological stimulus and drug effect
10.1016/0022-5193(78)90225-4 · 1978 · External reference
The mode of action of nicotine and curari, determined by the form of the contraction curve and the method of temperature coefficients
10.1113/jphysiol.1909.sp001344 · 1909 · External reference
"Receptive substances": John Newport Langley (1852-1925) and his path to a receptor theory of drug action
10.1017/s0025727300000090 · 2004 · External reference
The emergence of the drug receptor theory
10.1038/nrd875 · 2002 · External reference
Receptor occupancy and tissue response
10.1038/178697b0 · 1956 · External reference
Drug-Receptor Thermodynamics: Introduction and Applications
2001 · External reference
The activated complex in chemical reactions
10.1063/1.1749604 · 1935 · External reference
A quantitative investigation of the relationship between rate of access of a drug to receptor and the rate of onset or offset of action
10.1007/bf00246668 · 1964 · External reference
Interaction at end-plate receptors between different choline derivatives
10.1098/rspb.1957.0018 · 1957 · External reference
Drug-target residence time and its implications for lead optimization
10.1038/nrd2082 · 2006 · External reference
The drug-target residence time model: a 10-year retrospective
10.1038/nrd.2015.18 · 2016 · External reference
Residence time of receptor-ligand complexes and its effect on biological function
10.1021/bi8002023 · 2008 · External reference
Rebinding: or why drugs may act longer in vivo than expected from their in vitro target residence time
10.1517/17460441.2010.512037 · 2010 · External reference
Long-lasting target binding and rebinding as mechanisms to prolong in vivo drug action
10.1111/j.1476-5381.2010.00936.x · 2010 · External reference
Do enthalpy and entropy distinguish first in class from best in class?
10.1016/j.drudis.2008.07.005 · 2008 · External reference
Biased signaling as allosteric probe dependence: everything old is new again
10.1021/acs.biochem.4c00342 · 2026 · External reference
Signalling bias in new drug discovery: detection, quantification and therapeutic impact
10.1038/nrd3954 · 2013 · External reference
A modification of receptor theory
10.1111/j.1476-5381.1956.tb00006.x · 1956 · External reference
Rate theories for biologists
10.1017/s0033583510000120 · 2010 · External reference
Entropy and polarity control the partition and transportation of drug-like molecules in biological membrane
10.1038/s41598-017-18012-7 · 2017 · External reference
The influence of receptor kinetics on the onset and duration of action and the therapeutic index of NVA237 and tiotropium
10.1124/jpet.112.194456 · 2012 · External reference
Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors
10.1038/sj.bjp.0702164 · 1998 · External reference
The affinity-efficacy problem: an essential part of pharmacology education
10.1098/rsos.240487 · 2024 · External reference
On the nature of allosteric transitions: a plausible model
10.1016/s0022-2836(65)80285-6 · 1965 · External reference
Operational models of pharmacological agonism
10.1098/rspb.1983.0093 · 1983 · External reference
A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor
10.1016/s0021-9258(20)79672-9 · 1980 · External reference
The interaction between edrophonium (tensilon) and acetylcholine at the motor end-plate
10.1111/j.1476-5381.1957.tb00131.x · 1957 · External reference
Pharmacological receptors
1968 · External reference
Pathway and mechanism of drug binding to G-protein-coupled receptors
10.1073/pnas.1104614108 · 2011 · External reference
Kinetics for drug discovery: an industry-driven effort to target drug residence time
10.1016/j.drudis.2017.02.002 · 2017 · External reference
Single-molecule approaches to characterizing kinetics of biomolecular interactions
10.1016/j.copbio.2010.10.002 · 2011 · External reference
