Thyroid Lobectomy vs Total Thyroidectomy in Intermediate Molecular Risk Thyroid Cancer: A Randomized Clinical Trial

Young‐Ji Seo; Elena G Hughes; James X. Wu; Michael W. Yeh; Masha Jean Livhits

doi:10.1001/jamaoto.2026.2258

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Thyroid Lobectomy vs Total Thyroidectomy in Intermediate Molecular Risk Thyroid Cancer: A Randomized Clinical Trial

Young‐Ji Seo, Elena G Hughes, James X. Wu, Michael W. Yeh, Masha Jean Livhits

JAMA Otolaryngology–Head & Neck Surgery2026doi:10.1001/jamaoto.2026.2258

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Abstract

This randomized clinical trial sought to determine the proportion of eligible patients who would consent to randomization and complete either thyroid lobectomy or total thyroidectomy as assigned, with the goal of informing target enrollment of a future multicenter trial.

Authors

Young‐Ji Seo#1 Elena G Hughes#2 James X. Wu#3 Michael W. Yeh#4 Masha Jean Livhits#5

Institutions

University of California, Los Angeles

Provenance

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Confidence 98%

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External reference records

Reoperation rates after initial thyroid lobectomy for patients with thyroid cancer: a national cohort study.

10.1089/thy.2024.0128 · 2024

2025 American Thyroid Association management guidelines for adult patients with differentiated thyroid cancer.

10.1177/10507256251363120 · 2025

Trends in the management of localized papillary thyroid carcinoma in the United States (2000-2018).

10.1089/thy.2021.0557 · 2022

Risk assessment for distant metastasis in differentiated thyroid cancer using molecular profiling: a matched case-control study.

10.1002/cncr.33421 · 2021

Prognostic value of preoperative molecular testing and implications for initial surgical management in thyroid nodules harboring suspected (Bethesda V) or known (Bethesda VI) papillary thyroid cancer.

10.1001/jamaoto.2023.1494 · 2023

Optimising recruitment and informed consent in randomised controlled trials: the development and implementation of the Quintet Recruitment Intervention (QRI).

10.1186/s13063-016-1391-4 · 2016

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