Abstract
Abstract
BACKGROUND
The
APOE
ε4 allele has weaker association with ADRD outcomes in Hispanic/Latino populations compared to non‐Hispanic White and East Asian populations.
METHODS
We used whole‐genome sequencing data from 13,025 Hispanic/Latino adults to infer population groups (clusters) from short DNA sequences at the
APOE
gene region. We estimated the associations between these clusters and mild cognitive impairment (MCI) and age‐adjusted significant cognitive decline assessed via the Study of Latinos‐Investigation of Neurocognitive Aging (SOL‐INCA) study (
n
= 5334). We compared these associations to those of the conventional
APOE
alleles.
RESULTS
We identified three clusters of individuals. Relative to the largest Cluster 1, being in Cluster 3 had higher likelihood of having significant cognitive decline, with odds ratio (OR) = 1.47, 95% confidence interval (CI) [1.18, 1.84],
p
p
= 0.08. Associations of the ε4 allele with these traits were not statistically significant.
DISCUSSION
The new
APOE
profile has stronger risk association with age‐adjusted significant cognitive decline in SOL‐INCA Hispanics/Latinos compared to the ε4 allele.