Abstract
ABSTRACT
Three new alkaloids, colombiains
A
–
C
(
1
–
3
), together with 8 known ones (
4
–
11
), were isolated from the soft coral‐derived fungus
Cladosporium colombiae
CSGL 10M10. Their structures were elucidated by spectroscopic interpretation, electronic circular dichroism (ECD), and single‐crystal X‐ray crystallographic methods. Compounds
6
and
11
exhibited significant cardioprotective activity against oxygen‐glucose deprivation/reoxygenation (OGD/R)‐induced injury in H9c2 myocardial cell line at 10 µM. In addition, a preliminary network pharmacology analysis of compound
6
suggested that
β
‐carboline alkaloids might exert protective effects through a multi‐target, multi‐pathway mode of action, providing a rationale for future mechanistic studies.