Abstract
ABSTRACT
Objectives
There is limited evidence on the diagnostic yield of endoscopic ultrasound (EUS)‐guided tissue acquisition (TA) using fine‐needle biopsy (FNB) in autoimmune pancreatitis (AIP), particularly considering the newer end‐cutting needles. The aim of this meta‐analysis was to provide a pooled estimate of the diagnostic performance of EUS‐TA using FNB in AIP patients according to the needle type used.
Methods
A computerized bibliographic search was performed through April 2024. Pooled effects were calculated using a random‐effects model. The primary endpoint was diagnostic accuracy. Secondary outcomes were sample adequacy, rates of adequate material for levels 1 and 2 of histological diagnosis, definitive diagnosis reached with histology in addition to imaging/laboratory tests, and safety.
Results
Twelve studies (three prospective series and one randomized trial) with 496 patients were included. Overall diagnostic accuracy rate was 75% (66%–83%), with a superiority of end‐cutting needles over reverse bevel needles (80%, 70%–90% versus 49%, 21%–67%;
p
Conclusions
End‐cutting needles showed high diagnostic yield in patients with AIP, with a low rate of adverse events, and should be preferred over reverse bevel needles.