Inositol‐requiring 1/X‐box‐binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism

Randal J. Kaufman; Siyan Cao

doi:10.1002/emmm.201000076

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Inositol‐requiring 1/X‐box‐binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism

Randal J. Kaufman, Siyan Cao

EMBO Molecular Medicine2010doi:10.1002/emmm.201000076

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Abstract

Inositol-requiring 1 (IRE1)/X-box-binding protein 1 (XBP1)-mediated signalling represents the most conserved branch of the unfolded protein response. A series of recent studies reveal novel and potentially ancient roles for this pathway in the coordination of metabolic and immune responses.

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Randal J. Kaufman#1 Siyan Cao#2

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10.1101/gad.1324805

10.1038/nri2689

10.1016/j.cell.2008.07.021

10.1126/science.1158042

10.1073/pnas.0809677105

10.1038/ni.1857

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10.1038/nm.2099

10.1101/gad.14.2.152

10.1038/nature08762

10.1016/j.cmet.2009.04.009

10.1016/s0092-8674(01)00612-2

Inositol‐requiring 1/X‐box‐binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism

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