Abstract
ABSTRACT
Background and Aims
Pre‐pregnancy overweight/obese status among women with polycystic ovary syndrome (PCOS) could increase the risk of at least one adverse pregnancy outcome (APO). This study aimed to determine how pre‐pregnancy weight and PCOS impact pregnancy outcomes.
Methods
For the current study, we used data collected in the Tehran Lipid and Glucose Study (TLGS), a cohort study with an average of 23 years of follow‐up, including 1105 women. The incidences of APOs, including gestational diabetes (GDM), preeclampsia (PE), and preterm birth, were compared between groups with different categories of pre‐pregnancy body mass index (18–24.9, 25–29.9, ≥ 30 kg/m
2
), PCOS, and non‐PCOS groups. The risk ratio (RR) and 95% confidence interval (95% CI) were estimated using the generalized linear models after adjusting for confounding factors. The participants included 864 non‐PCOS women and 241 women with PCOS.
Results
Findings showed that the incidence rate of at least one APO among women with PCOS compared with non‐PCOS group was not significant (32.4% vs. 26.4%,
p
> 0.05). Obese women with PCOS (RR: 2.01; 95% CI: 1.11–3.62) and non‐PCOS (1.75; 1.10–2.79) were at increased risk of GDM compared to non‐PCOS normal weight women. Also, obese women with PCOS were at increased risk of PE (1.80; 1.08–2.97) compared to the non‐PCOS normal weight women. Overweight and obese women with PCOS were at increased risk of at least one APO (1.57; 1.06–2.32) and (1.44; 1.03–2.02), respectively.
Conclusion
The study found that women with PCOS with pre‐pregnancy overweight/obese status are at increased risk of at least one APO and GDM. Management of pre‐pregnancy weight should be promoted in women with PCOS.