Use of Ibuprofen Before and in Early Pregnancy Among Women With and Without Chronic Medical Diseases. A Cross‐Sectional Study

ABSTRACT Purpose While having a chronic medical disease (CMD) increases use of analgesics and anti‐inflammatory drugs, sufficient knowledge regarding patterns of use during pregnancy is lacking. We aimed to describe ibuprofen use before and in early pregnancy among women with and without CMD, and to assess the associations between CMD and ibuprofen use before and in early pregnancy. Methods We used self‐reported data from 24 018 pregnancies from the Copenhagen Pregnancy Cohort (2013–2019) to compare ibuprofen use between women with and without CMD. Descriptive statistics and multivariable logistic regression models were applied. Results Women with CMD reported higher ibuprofen use before and in early pregnancy. However, use was markedly reduced from before to early pregnancy in both groups: from 19.8% to 0.61% among women with CMD ( p   Conclusions Use of ibuprofen was markedly reduced in early pregnancy, among both women with and without CMD. Having CMD was associated with increased ibuprofen use before and in early pregnancy.