Supramolecular Behaviour of Heterochiral Dipeptides With Ile

Erica Scarel; Paola Alletto; Simone Adorinni; Fabio Fazio; Giovanni Pierri; Consiglia Tedesco; Silvia Marchesan

doi:10.1002/psc.70121

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Supramolecular Behaviour of Heterochiral Dipeptides With Ile

Erica Scarel, Paola Alletto, Simone Adorinni, Fabio Fazio, Giovanni Pierri, Consiglia Tedesco, Silvia Marchesan

Journal of Peptide Science2026doi:10.1002/psc.70121

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Abstract

ABSTRACT This study describes the supramolecular behaviour and gelation of heterochiral, aliphatic dipeptides d ‐Ile‐ l ‐Xaa (Xaa = Ala, Val, Leu or Ile) in various solvents and buffered water at neutral pH. In the case of metastable gels, the consequent rapid transition towards crystals enabled X‐ray diffraction analysis to unveil the dipeptides' packing modes in amphipathic layers.

Authors

Erica Scarel#1 Paola Alletto#2 Simone Adorinni#3 Fabio Fazio#4 Giovanni Pierri#5 Consiglia Tedesco#6 Silvia Marchesan#7

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10.1126/science.1082387

10.1002/mabi.202400523

10.1002/cmdc.202300258

10.1039/d4tb01235f

10.1002/psc.3377

10.1016/j.jmb.2024.168646

10.1002/chem.202400622

10.3390/nano13020333

10.3390/molecules28072917

10.1126/science.aam9756

10.1021/acs.biomac.4c01179

10.1107/s2052520618007151

Supramolecular Behaviour of Heterochiral Dipeptides With Ile

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