Abstract
ABSTRACT
Rationale
In this study, the phytochemical composition, in vitro anticancer activity, photodynamic therapy (PDT) activity, and molecular interaction potential with carbonic anhydrase IX (CA IX) of
Cakile maritima
methanol extract were evaluated.
Methods and Results
LC–MS/MS analysis identified 11 compounds among 35 screened phytochemicals, with fumaric acid (13797.19 ppb), ferulic acid (771.37 ppb) and p‐coumaric acid (601.95 ppb) accounting for approximately 97% of the total content. Molecular docking results demonstrated that sinapic acid (−6.13 kcal/mol) and quinic acid (−6.11 kcal/mol) exhibited the highest binding affinities toward CA IX. Cell culture studies revealed that LogIC
50
values differed significantly among cell lines (
p
p
Conclusions
These findings indicate that
C. maritima
methanol extract exhibits light‐enhanced cytotoxicity in MKN‐28 gastric cancer cells and warrant further investigation regarding its potential photosensitising properties.