Incidence of pre‐eclampsia in triplet pregnancies with and without embryo reduction

ABSTRACT Objective To determine the risk of pre‐eclampsia (PE) in triplet pregnancies, with and without embryo reduction, compared to singleton and twin pregnancies. Methods This was a retrospective multicenter study of triplet pregnancies with three live, phenotypically normal fetuses at the 11–13‐week scan and a gestational age at delivery of ≥ 24 weeks. The competing‐risks model was used to determine the distribution of gestational age at delivery with PE in each type of triplet pregnancy, which was compared to datasets from 1169 twin pregnancies and 61 174 singleton pregnancies from previous cohorts. The relative risks of PE with delivery Results Overall, 1020 triplet pregnancies were included, of which 456 had expectant management, 468 were reduced to twin pregnancies and 96 were reduced to singleton pregnancies. The incidence of PE with delivery Conclusion Non‐reduced triplet pregnancies have a 21‐fold and 8‐fold higher risk of delivery with PE at Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.