Polygenic control of autoimmune diabetes in nonobese diabetic mice
10.1038/ng0893-404 · 1993
Breeding of a non-obese, diabetic strain of mice
1980
Genetics of insulin-dependent diabetes mellitus
10.1507/endocrj.43.605 · 1996
Genetic analysis of auto-immune disease
10.1016/s0092-8674(00)81110-1 · 1996
Localization of two insulin-dependent diabetes (Idd) genes to the Idd 10 region on mouse chromosome 3
10.1007/s003359900749 · 1998
Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgr1
10.4049/jimmunol.159.4.1835 · 1997
Evidence for the presence of insulin-dependent diabetes-associated alleles on the distal part of mouse chromosome 6
10.1101/gr.8.6.608 · 1998
The NOD Idd9 genetic interval influences the pathogenicity of insulitis and contains molecular variants of Cd30, Tnfr2, and Cd137
10.1016/s1074-7613(00)00012-1 · 2000
NOD Idd5 locus controls insulitis and diabetes and overlaps the orothologous CTLA4/IDDM12 and NRAMP1 loci in humans
10.2337/diabetes.49.10.1744 · 2000
The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD
10.1016/s1074-7613(00)80392-1 · 1997
Programmed cell death in the pathogenesis of murine IDDM: resistance to apoptosis induced in lymphocytes by cyclophosphamide
10.1006/jaut.1996.0034 · 1996
Non-obese diabetic (NOD) mice display enhanced immune responses and prolonged survival of lymphoid cells
10.1093/intimm/6.2.339 · 1994
Genetic analysis of immune dysfunction in non-obese diabetic (NOD) mice: mapping of a susceptibility locus close to the Bcl-2 gene correlates with increased resistance of NOD T cells to apoptosis induction
10.1002/eji.1830240217 · 1994
Type 1 diabetes and the control of dexamethazone-induced apoptosis in mice maps to the same region on chromosome 6
10.1006/geno.1995.1167 · 1995
Identification and mapping to chromosome 1 of a susceptibility locus for periinsulitis in non-obese diabetic mice
10.1038/353260a0 · 1991
Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/Ity/Bcg genes on chromosome 1 [see comments]
10.1038/353262a0 · 1991
Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region
10.1073/pnas.94.16.8670 · 1997
Autoimmune syndromes in major histocompatibility complex (MHC) congenic strains of nonobese diabetic (NOD) mice: The NOD MHC is dominant for insulitis and cyclophosphamide-induced diabetes
10.1084/jem.176.1.67 · 1992
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
10.1126/science.270.5238.985 · 1995
Towards construction of a high resolution map of the mouse genome using PCR-analysed microsatellites
10.1093/nar/18.14.4123 · 1990
MAPMAKER: an interactive computer package for constructing primary genetic linkage maps of experimental and natural populations
10.1016/0888-7543(87)90010-3 · 1987
Mapping mendelian factors underlying quantitative traits using RFLP linkage maps [published erratum appears in Genetics 1994 Feb;136(2):705]
10.1093/genetics/121.1.185 · 1989
CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation
10.1084/jem.182.2.459 · 1995
The role of CTLA-4 in the regulation and initiation of T-cell responses
10.1111/j.1600-065x.1996.tb00919.x · 1996
The emerging role of CTLA-4 as an immune attenuator
10.1016/s1074-7613(00)80366-0 · 1997
Role of interleukin 12 and costimulators in T cell anergy in vivo
10.1084/jem.186.7.1119 · 1997
Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
10.1016/s1074-7613(00)80284-8 · 1997
CTLA-4: a negative regulator of autoimmune disease
10.1084/jem.184.2.783 · 1996
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
10.1016/1074-7613(95)90125-6 · 1995
Impaired negative selection in CD28-deficient mice
10.1006/cimm.1998.1332 · 1998
Sublethal gamma-radiation induces differentiation of CD4−/CD8− into CD4+/CD8+ thymocytes without T cell receptor beta rearrangement in recombinase activation gene 2−/− mice
10.1084/jem.180.4.1517 · 1994
Induction of T cell differentiation and lymphomagenesis in the thymus of mice with severe combined immune deficiency (SCID)
10.4049/jimmunol.153.3.1004 · 1994
Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor beta chain-independent pathway
10.1084/jem.181.3.1187 · 1995
Lck dependence of signaling pathways activated by gamma-irradiation and CD3 epsilon engagement in RAG-1(−/−)-immature thymocytes
10.1093/intimm/8.7.1159 · 1996
Pre-TCR signaling and inactivation of p53 induces crucial cell pathways in pre-T cells
10.1016/s1074-7613(00)80084-9 · 1999
V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors
10.1101/gad.10.16.2038 · 1996
Apoptosis induced by gamma-irradiation, but not CD4 ligation, of peripheral T lymphocytes in vivo is p53-dependent
10.1002/(sici)1096-9896(199702)181:2<166::aid-path740>3.0.co;2-d · 1997
1,25-Dihydroxyvitamin D3 restores sensitivity to cyclophosphamide-induced apoptosis in non-obese diabetic (NOD) mice and protects against diabetes
10.1046/j.1365-2249.1998.00568.x · 1998
Sex difference in resistance to dexamethasone-induced apoptosis in NOD mice. Treatment with 1,25(OH)2D3 restores defect
10.2337/diabetes.47.7.1033 · 1998
Streptococcal wall component OK432 restores sensitivity of non-obese diabetic (NOD) thymocytes to apoptotic signals
10.1007/s001250051526 · 2000
