Transformation von Deoxynivalenol durch die Darmflora des Schweines — In-vitro Untersuchungen zur Adaptation in Abhängigkeit von der Darreichungsform

To examine the biotransformation of Deoxynivalenol (DON) by the normal gut flora of pigs (in reliance on toxin-source) an in-vitro system was established. Suspensions of rectum contents from different treated animals were incubated with pure DON. Despite fast adaptation of microflora (Deepoxidation of DON) of animals fed wheat diet, no effects on reduced feed consumption and weight gain were seen. Even fast adaptation of microflora (lower intestine) couldn't avoid DON-effects in vivo.