Abstract
Based on the results of monitoring the hemostatic potential, tumor volume, and metastatic characteristics in C57BL/6 mice with transplanted Lewis lung carcinoma receiving a single intraperitoneal injection of cisplatin, we explain the mechanism underlying the wave-like dynamics of hemostasis. The cytostatic agent was found to eliminate the consumption of blood coagulation factors. The response of the hemostatic potential to total paraneoplastic injury and its key components (tumor size, metastasis, and chemotherapy) demonstrates a clear synergy that significantly exceeds the sum of the individual thrombogenic stimuli.