Abstract
The effect of synthetic kisspeptin-14 on cortisol levels during embryogenesis was evaluated in vivo using a Danio rerio model. Cortisol concentrations were measured by ELISA in D. rerio embryo homogenates after exposure to synthetic kisspeptin-14 at concentrations of 10, 20, and 50 ng/mL at different stages of embryogenesis (10, 48, and 72 h post-fertilization). A significant decrease in cortisol levels was found at all these terms. These findings open up prospects for the development of therapeutic strategies based on peptide analogs for the correction of reproductive disorders associated with hypercortisolemia.