Abstract
We tested disk-shaped implants (5.0 mm in diameter) fabricated from VT6 titanium alloy with calcium phosphate coating (sample 1) and with an additional functional coating with a Schiff base (sample 2). Control samples were left uncoated. The antibacterial effect against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa strains was evaluated in vitro. The safety of the test implants was studied in vivo after subcutaneous implantation to Wistar rats. Both experimental samples demonstrated a weak bactericidal effect against P. aeruginosa strain. In the in vivo experiments, sample 2 showed signs of cardiotoxicity.