Abstract
The wound-healing efficacy of the FENIX gel, containing poloxamer 188, alpha-fetoprotein, and perfluorodecalin, was evaluated in a model of 3-cm2 skin flap excision in Sprague-Dawley rats. Daily topical application of the gel for 21 days accelerated wound contraction at a rate comparable to the reference products Kelo-Cote and Contractubex. During the wound closure phase, both FENIX gel and the reference preparation Contractubex promoted the formation of mature scar tissue and dermal connective tissue, while inducing minimal reactive epidermal hyperplasia and preserving hypodermal elements, leading to the timely resolution of reparative processes in the injured skin by day 41 post-excision.