Abstract
Abstract
Objective
The performance of
18
F-labeled prostate-specific membrane antigen (
18
F-PSMA-1007) positron emission tomography/computed tomography (PET/CT) and bone scintigraphy (BS) for detecting bone metastases in prostate cancer patients was compared.
Materials and methods
One hundred prostate cancer patients (initial staging,
n
= 9; biochemical recurrence,
n
= 63; metastatic castration-resistant prostate cancer (mCRPC),
n
= 15; m0CRPC,
n
= 13) underwent
18
F-PSMA-1007 PET/CT and BS. The patient-, region-, and lesion-based performances of
18
F-PSMA-1007 PET/CT and BS for detecting bone metastases were evaluated by experienced readers using a five-point scale.
Results
Bone metastases were identified in 46 (46.0%) patients, 99 (24.8%) of the 400 regions, and 528 lesions. In the analysis, the area under the receiver-operating-characteristic curve (AUC), sensitivity, specificity, and accuracy values for
18
F-PSMA-1007 PET/CT were 0.9985, 100%, 94.4%, and 97.0%, respectively, whereas those for BS were 0.8507, 71.7%, 88.9%, and 81.0%, respectively. AUC, sensitivity, and accuracy were significantly higher for
18
F-PSMA-1007 PET/CT than for BS (
p
= 0.00021,
p
= 0.00087, and
p
= 0.00018, respectively; McNemar test).
18
F-PSMA-1007 PET/CT detected 527 of the 528 metastatic lesions (99.8%), whereas BS detected 253 (47.9%) (
p
20 lesions for BS were 13, 21, 0, 8, and 4, respectively, compared with 0, 27, 3, 9, and 7, respectively, on
18
F-PSMA-1007 PET/CT. In addition,
18
F-PSMA-1007 PET/CT detected local recurrence (
n
= 51), nodal metastases (
n
= 37), and visceral metastases (
n
= 4).
Conclusions
18
F-PSMA-1007 PET/CT demonstrated higher sensitivity and accuracy than BS for detecting bone metastases in prostate cancer patients.