Pathogenesis of Parkinson’s disease: oxidative stress, environmental impact factors and inflammatory processes

Jing-Chen Zheng; Shao-Feng Zhang; Jian-Yang Xu; Li-Min Bai

doi:10.1007/s12264-007-0018-x

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Pathogenesis of Parkinson’s disease: oxidative stress, environmental impact factors and inflammatory processes

Jing-Chen Zheng, Shao-Feng Zhang, Jian-Yang Xu, Li-Min Bai

Neuroscience Bulletin2007doi:10.1007/s12264-007-0018-x

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Abstract

Current hypothesis of neuronal degeneration in Parkinson's disease (PD) have been proposed, including formation of free radicals and oxidative stress, mitochondrial dysfunction, excitotoxicity, trophic factor deficiency, inflammatory processes, genetic factors, environmental impact factors, toxic action of nitric oxide, apoptosis, and so on. This review mainly discussed oxidative stress, environmental impact factors, and inflammatory processes in PD.

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Jing-Chen Zheng#2 Shao-Feng Zhang#4 Jian-Yang Xu#5 Li-Min Bai#6

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Pathogenesis of Parkinson’s disease: oxidative stress, environmental impact factors and inflammatory processes

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