Changes of 5-hydroxytryptamine and tryptophan hydroxylase expression in the ventral horn of spinal cord

Chuan-Xiang Xu; Hong-Tao Liu

doi:10.1007/s12264-008-1031-4

Enriched recordOpen access

Changes of 5-hydroxytryptamine and tryptophan hydroxylase expression in the ventral horn of spinal cord

Chuan-Xiang Xu, Hong-Tao Liu

Neuroscience Bulletin2008doi:10.1007/s12264-008-1031-4

Citation graph

Abstract

Objective To investigate changes of 5-hydroxytryptamine (5-HT) and its synthesis rate-limiting enzyme tryptophan hydroxylase (TPH) in the ventral horn of spinal cord after exercise-induced fatigue, and to further discuss the mechanism of exercise-induced central fatigue at spinal level.Methods Sixteen healthy adult Wistar rats were randomly divided into 2 groups: exercise-induced fatigue group and control group. Immunohistochemical staining for 5-HT and TPH in the ventral horn were performed and analyzed quantitatively. The mean optic densities of 5-HT and TPH positive fibers or terminals were measured by computerized image analyzer.Results Both 5-HT and TPH positive fibers/terminals decreased in the exercise-induced fatigue group. The immunohistochemical staining was weaker and the mean optic densities decreased obviously in the fatigue group compared with those in the control group (PConclusion 5-HT and TPH in the ventral horn of spinal cord might be involved in exercise-induced fatigue.

Authors

Chuan-Xiang Xu#1 Hong-Tao Liu#2

Institutions

No ROR-resolved institution is linked to this work yet.

Provenance

crossref

Confidence 100%

pubmed

Confidence 98%

europepmc

Confidence 96%

unpaywall

Confidence 95%

datacite

Confidence 0%

Referenced works

View all references →

No local reference links have been materialized yet.

Cited by

View all cited-by records →

Beneficial effects of moderate voluntary physical exercise and its biological mechanisms on brain health

2008 · 0 citations

External reference records

10.1007/978-1-4899-1016-5_25

10.1007/978-1-4899-1016-5_25 · 1995

Unresolved referenced work

1981

10.1002/(sici)1096-9861(19980330)393:13.0.co;2-o

10.1002/(sici)1096-9861(19980330)393:1<69::aid-cne7>3.0.co;2-o · 1998

10.1016/0166-2236(93)90090-9

10.1016/0166-2236(93)90090-9 · 1993

Unresolved referenced work

1994

Unresolved referenced work

2002

Unresolved referenced work

1995

10.1152/physrev.1992.72.1.165

10.1152/physrev.1992.72.1.165 · 1992

10.1016/s0006-3223(98)00133-4

10.1016/s0006-3223(98)00133-4 · 1998

10.1093/jn/136.2.553s

10.1093/jn/136.2.553s · 2006

10.1016/j.brainres.2005.12.007

10.1016/j.brainres.2005.12.007 · 2006

10.1016/0165-0270(94)90121-x

Changes of 5-hydroxytryptamine and tryptophan hydroxylase expression in the ventral horn of spinal cord

Referenced works

Cited by

External reference records

Additional external references