High expression of CD74 is associated with poor prognosis and tumor immune infiltration in Acute Myeloid Leukemia

Objective To investigate the expression patterns of the CD74 gene in Acute Myeloid Leukemia (LAML), its clinical prognostic significance, and its association with the tumor microenvironment (TME).Methods Data from public databases, including TCGA and GTEx, were integrated to analyze the differences in CD74 expression between LAML tissues and normal controls; perform subgroup analysis based on clinical and pathological characteristics; evaluate its prognostic value using survival analysis and ROC curves; elucidate its potential immune regulatory mechanisms through the CIBERSORT algorithm and functional enrichment analysis.Results CD74 was significantly overexpressed in LAML tissues, with higher expression observed in the monocyte-derived subtypes (M4-M7) and in patients with high white blood cell counts (P Conclusion High CD74 expression is associated with poor prognosis in patients with LAML and may promote disease progression by reshaping the immune microenvironment; it holds promise as a new prognostic marker and immunotherapy target.