High-dose vitamin D supplementation in multiple sclerosis: a systematic review of clinical effects and future directions

Abstract Vitamin D deficiency is common in multiple sclerosis (MS) patients. This review explores the potential benefits and limitations of high-dose vitamin D supplementation in MS management. We reviewed relevant literature on the effects of high-dose vitamin D supplementation on relapse rates, disability progression, quality of life, and MRI markers of disease activity in MS patients. Additionally, we discussed the mechanisms by which vitamin D might influence MS, potential adverse effects, and future research directions. Studies suggest that high-dose vitamin D supplementation may reduce relapse rates and improve MRI markers of disease activity in MS. However, the evidence for its impact on disability progression and quality of life remains inconclusive. Vitamin D’s immunomodulatory properties are well-documented, and its potential for neuroprotection and neurogenesis warrants further investigation. High-dose vitamin D supplementation holds promise as a complementary or disease-modifying therapy for MS. However, further robust research is required to solidify its role in clinical practice. Exploring vitamin D’s multifaceted effects on the immune system, neuroprotection, and neurogenesis paves the way for novel therapeutic strategies to improve the lives of individuals with MS.