Vascular Aging–Driven Tumor-Like Transformation of Vascular Smooth Muscle Cells in Atherosclerotic Cardiovascular Disease: Mechanisms and Therapeutic Targets

The novel piperlongumine-ligustrazine derivative PL-Lig-11 inhibits VSMC phenotypic switching and intimal hyperplasia via the PDGFRα/β-RhoGDI3-NLRP3 inflammasome axis

10.1016/j.cbi.2026.112083 · doi-reference

Fibroblast growth factor 21 promotes vascular smooth muscle cell contractile polarization via p38 mitogen-activated protein kinase-promoted serum response factor phosphorylation

10.34133/research.0815 · doi-reference

OGG1: an emerging multifunctional therapeutic target for the treatment of diseases caused by oxidative DNA damage

10.1002/med.22068 · doi-reference

Clinical risk factors of bevacizumab-related hypertension in patients with metastatic colorectal cancer: a retrospective study

10.3389/fphar.2024.1463026 · doi-reference

DNA damage response, a double-edged sword for vascular aging

10.1016/j.arr.2023.102137 · doi-reference

Neovascularization in atherosclerotic plaques: clinical implications, detection, and prevention strategies

10.31083/rcm36468 · doi-reference

Phenotypic switching of atherosclerotic smooth muscle cells is regulated by activated PARP1-dependent TET1 expression

10.5551/jat.55343 · doi-reference

TEAD1-mediated trans-differentiation of vascular smooth muscle cells into fibroblast-like cells contributes to the stabilization and repair of disrupted atherosclerotic plaques

10.1002/advs.202407408 · doi-reference

The effects of ultrasound-targeted microbubble destruction (UTMD) carrying IL-8 monoclonal antibody on the inflammatory responses and stability of atherosclerotic plaques

10.1016/j.biopha.2019.109161 · doi-reference

Cyclic stretch induces vascular smooth muscle cells to secrete connective tissue growth factor and promote endothelial progenitor cell differentiation and angiogenesis

10.3389/fcell.2020.606989 · doi-reference

Poly(ADP-ribose) polymerase 1 orchestrates vascular smooth muscle cell homeostasis in arterial disease

10.1038/s12276-025-01501-5 · doi-reference

Global burden of atherosclerotic cardiovascular disease attributed to lifestyle and metabolic risks

10.1007/s11427-025-2948-y · doi-reference

Peanut skin extract ameliorates high-fat diet-induced atherosclerosis by regulating lipid metabolism, inflammation reaction and gut microbiota in ApoE−/− mice

10.1016/j.foodres.2022.111014 · doi-reference

Integrative single-cell analysis reveals endothelial diversity in the vasa vasorum of human atherosclerosis

10.1038/s42003-026-10095-1 · doi-reference

Potential role of ATM in hepatocyte endocytosis of ApoE-deficient, ApoB48-containing lipoprotein in ApoE-deficient mice

10.3892/ijmm.2013.1566 · doi-reference

Cellular mechanisms of oligoclonal vascular smooth muscle cell expansion in cardiovascular disease

10.1093/cvr/cvac138 · doi-reference

Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis

10.1038/s41591-019-0512-5 · doi-reference

ECM modifications driven by age and metabolic stress directly promote vascular smooth muscle cell osteogenic processes

10.1161/atvbaha.124.321467 · doi-reference

Sentrin-specific protease 3 (SENP3)-mediated Krüppel-like factor 4 (KLF4) deSUMOylation regulates vascular smooth muscle cell phenotypic switching in atherosclerosis

10.1186/s43556-025-00365-5 · doi-reference

Impacts of aging and fluid shear stress on vascular endothelial metabolism and atherosclerosis development

10.1186/s12929-025-01177-z · doi-reference

Deletion of SIRT6 in vascular smooth muscle cells facilitates vascular calcification via suppression of DNA damage repair

10.1016/j.yjmcc.2022.10.009 · doi-reference

Vascular aging impairs active modulation of murine aortic stiffness by smooth muscle cells

10.1152/ajpcell.00387.2025 · doi-reference

Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury

10.1038/s42003-021-02123-z · doi-reference

DNA damage and repair in vascular disease

10.1146/annurev-physiol-021115-105127 · doi-reference

Impairment of macrophage functions by the senescence-associated secretory phenotype of vascular smooth muscle cells-brief report

10.1161/atvbaha.125.324299 · doi-reference

Integrated single-cell atlas of human atherosclerotic plaques

10.1038/s41467-025-63202-x · doi-reference

Targeting senescent cells in atherosclerosis: pathways to novel therapies

10.1016/j.arr.2024.102502 · doi-reference

Focal adhesion kinase promotes calcification of vascular smooth muscle cells via regulation of histone deacetylase 4 and 5

10.1161/atvbaha.123.319010 · doi-reference

Resection of DNA double-strand breaks activates Mre11-Rad50-Nbs1- and Rad9-Hus1-Rad1-dependent mechanisms that redundantly promote ATR checkpoint activation and end processing in Xenopus egg extracts

10.1093/nar/gkae082 · doi-reference

Single-cell multimodal profiling highlights persistent aortic smooth muscle cell changes in diabetic mice despite glycemic control

10.1161/atvbaha.125.324012 · doi-reference

PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition

10.1038/s44161-025-00737-8 · doi-reference

Intraplaque neovascularization and progression of atherosclerosis: a review of SMI technical assessment and berberine-statin regulatory mechanisms

10.1097/md.0000000000046174 · doi-reference

Roles of Brd4 in vascular smooth muscle cells: implications for aging and vascular dysfunction

10.1161/atvbaha.124.322158 · doi-reference

Pro-ferroptotic signaling promotes arterial aging via vascular smooth muscle cell senescence

10.1038/s41467-024-45823-w · doi-reference

Mutational landscape of atherosclerotic plaques reveals large clonal cell populations

10.1172/jci.insight.188281 · doi-reference

Minocycline reduces plaque size in diet induced atherosclerosis via p27(Kip1)

10.1016/j.atherosclerosis.2011.05.041 · doi-reference

Defective base excision repair of oxidative DNA damage in vascular smooth muscle cells promotes atherosclerosis

10.1161/circulationaha.117.033249 · doi-reference

Role of diverse smooth muscle cell phenotypic transitions in atherosclerosis development and late-stage pathogenesis

10.1146/annurev-physiol-052824-084232 · doi-reference

A possible role for proinflammatory activation via cGAS-STING pathway in atherosclerosis induced by accumulation of DNA double-strand breaks

10.1038/s41598-023-43848-7 · doi-reference

Vascular niches are the primary hotspots in cardiac aging

10.1161/circresaha.125.327060 · doi-reference